Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"6R"”.
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Molecular analysis of structure of chromosome 6R of triticale T701-4-6 / by Sadia Kabir.
Rye chromosome 6R in triticale contains a gene useful for resistance to cereal cyst nematode. This study shows that the complex structure of this chromosome may prevent render its use impracticle in introgression of this resistance into wheat.
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Einfluß des IL-6/sIL-6R Fusionsproteins Hyper Interleukin-6 auf die Leber nach hydrodynamischer Transfektion in vivo
… Studien konnte gezeigt werden, dass ein IL-6/sIL-6R Fusionsprotein, Hyper-IL-6, nach Leberschädigung stark regenerationsfördernd wirkt. In der vorliegenden Arbeit konnte Hyper-IL-6 Expression (unterschiedlicher Höhe und Dauer) zwischen 1 ng/ml (SV40, hAAT) und 1000 ng/ml (CMV) für 1-2 Tage (CMV, …
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Solid-supported synthesis of peptidoglycan fragments and their biological evaluation
… of peptidoglycan fragments containing (2S,6R)-A2pm is proposed. Thanks to a solid phase platform, cross metathesis was achieved between two easily manufactured chiral synthons, allylglycine anchored to a resin and vinylglycine derivatives. Due to the need of fragments for the study of the …
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Synthesis, Superstructure, Vacancy-Ordering of Intercalated Transition Metal Dichalcogenides
… transition metal dichalcogenides (TMDCs) 6R-CuxTa1+yS2 and 2H-CuxTa1+ySe2, as well as the compound Cu3TaSe4. Synthesis of these compounds has been performed by the method of chemical vapor transport, using iodine as a transporting agent. X-ray diffraction may reveal superlattice …
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The role of central IL-6 signalling in the development of Type 2 Diabetes
… a CRE-mediated nervous-system specific NesCreIL-6R knock-down (KD) mouse. Chronic administration of high-fat diet (>40% fat) in mice is commonly used to model the effects of diet-induced obesity and the progression to type 2 diabetes in humans. To examine the effects of this intervention in the …
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Mechanism of TNF-α cytotoxicity in a leukemia virus transformation model
… to be insensitive to TNF-α and another clone (6R.1) which had an increased sensitivity to TNF-α. The differential cytotoxicity was observed when cells were treated with TNF-α, for 18 hr, at 0 to 100 units/ml, at 37°C. The mechanism of this differential cytotoxicity was further investigated. …
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Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
… a cAMP-mediated inhibition of soluble IL-6Rα (sIL-6R)/IL-6-stimulated extracellular regulated mitogen-activated protein kinase 1, 2 (ERK1,2) and signal transducer and activator of transcription 3 (STAT3) activation in HUVECs, which was independent of cAMP-dependent protein kinase A (PKA). …
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The Association Between Cancer-Related-Fatigue, Response to Fatigue Treatment, and Cytokines and Their Receptors, In Patients With Advanced Cancer
… and receptor antagonist (IL-1RA), IL-6, IL-6R, TNF-α and sTNF-R1 and R2, IL-8, IL-10, IL-17] levels measured by Luminex. Data were analyzed using principal component analysis (PCA) [reporting cumulative variance (variance) for the first four components] to determine their association with …
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Investigation of chemokine expression and modulation following traumatic brain injury
… and soluble interleukin-6 receptor (sIL-6R) to contusion enlargement has not been investigated. In this thesis, I investigated chemokine expression and modulation both in in-vitro, in-vivo models and in a clinical study. Initially, I compared chemokine expression in rodent and human glial …
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Improved Synthesis, Separation, Transition Metal Coordination and Reaction Chemistry of a New Binucleating Tetraphosphine Ligand
… 4R and [rac-Rh2(nbd)2(et,ph-P4)](BF4)2, 6R, in which et,ph-P4-Ph acts as a bridging and chelating ligand. Heterobimetallic complex, NiPtCl4(rac-et,pt-P4-Ph), 5R has been prepared by reaction of rac- et,ph-P4-Ph with 1 equiv of Ni2Cl4∙6H2O, followed by dropwise addition of 1 equiv of …
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Synthetic studies on the spiroacetal moiety of stenocarpin, a metabolite of Diplodia maydis
… established the structure as either (3S,4R,6R,7R)- or (3R,4R,6R,7R)-spiro[(4,6, 7-trihydroxy-7-methyl-8-oxo-5,6,7,8-tetrahydroisochromane)-3 ,2' -tetrahydrofuran]. The absolute configuration of the C(3) spiroacetal stereogenic center remained unknown. The aim of the synthetic studies …
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Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem : lokale Applikation d. Designerzytokins Hyper-Interleukin-6 im adulten Organismus d. Ratte u. Auswirkungen v. exzitatorischen Neurotoxinen im Interleukin-6 transgenen Mausmodell
… verbunden mit löslichem IL-6 Rezeptor (sIL-6R). Erstmalig wurden hierfür makroverkapselte, H-IL-6 exprimierende Maus-Melanomzellen (B78 Zellen) verwendet und deren Auswirkungen zwei und vier Wochen nach Implantation in das Striatum der Ratte untersucht. Deutlichstes Kennzeichen im striatalen …
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Topological analysis of singularity loci for serial and parallel manipulators
… none exists. Examples of applications to 3R and 6R serial manipulators, to 3UPS and 3UPU parallel wrists, to 3UPU parallel translational manipulators, and to 3RRR planar manipulators are reported in the work.
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Effetti cardiotossivi precoci e tardivi del trattamento con Epirubicina. Valutazione con marker biochimici ed ecocardiografia Tissue Doppler.
… became significant. Levels of IL-6, sIL-6R and ROS increased significantly at 200 mg/m2 and IL-6 persisted high at 300 and 400 mg/m2 Epi dose returning within baseline values during follow-up. A significant inverse correlation between ΔSR and both the increase of IL-6 and ROS was …
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Electrophilic Affinity Labels and Fluorescent Conjugates for the Estrogen Receptor (Norhexestrol, Aziridine, Hexestrol, Fluorescein, Alkylator)
… (MCF-7 cell line). Norhexestrol aziridine 34 ((6R*,7S*)-1-(N-aziridinyl)-6,7-bis(4-hydroxyphenyl)-5-nonanone) had the most potential as an estrogenic affinity labeling agent because of its agonistic properties, and its rapid, efficient irreversible binding to the receptor. Therefore, …
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ASSESSING THE EFFECTS OF KETAMINE AND ITS ENANTIOMERS ON COMPULSIVE-LIKE AND DEPRESSIVE-LIKE BEHAVIOR
… 6<em>R</em>)-Hydroxynorketamine ((2R, 6R)-HNK) using the marble burying test, a model to assess anti-compulsive effects of drugs, and the novel suppressed feeding test, a model to assess the antidepressant-like effects of drugs. Further, tests were conducted 0.5 and 72 hours after …
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Characterisation of cytokine secretion in malignant gliomas
… soluble interleukin-6 receptor alpha (sIL-6R alpha), platelet-derived growth factor - AABB (PDGF-AABB), platelet and endothelial cell adhesion molecule (PECAM-1), stem cell factor (SCF), prolactin, soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) and urokinase plasminogen …
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Investigating the Interactions Between the Thiolate Ligand and Mutants of a Conserved Tryptophan in the Proximal Heme Pocket of the Oxygenase Domains of Endothelial and Staphyloccus Aureus Nitric Oxide Synthases
… mutated residue in the absence of the cofactor (6R)5,6,7,8-tetrahydrobiopterin (H4B). The mutants also displayed relative rates of NO2- production that were comparable to the nNOSoxy mutants, which is consistent with the nNOSoxy results. The presence of H4B alters porphyrin planarity, which …
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