Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 48 for “"6R"”.
-
Entwicklung und Charakterisierung eines IL-6-Inhibitors basierend auf Funktionsanalysen des murinen IL-6R alpha
… namely domains D1 to D3 of gp130 and D2-D3 of IL-6R alpha. The present study aimed at the generation of an IL-6-inhibitor based on the murine receptor proteins for the future validation of the fusion protein concept in aminal studies. Although murine and human IL-6R alpha and gp130 proteins show a …
-
Molecular analysis of structure of chromosome 6R of triticale T701-4-6 / by Sadia Kabir.
Rye chromosome 6R in triticale contains a gene useful for resistance to cereal cyst nematode. This study shows that the complex structure of this chromosome may prevent render its use impracticle in introgression of this resistance into wheat.
-
Einfluß des IL-6/sIL-6R Fusionsproteins Hyper Interleukin-6 auf die Leber nach hydrodynamischer Transfektion in vivo
… Studien konnte gezeigt werden, dass ein IL-6/sIL-6R Fusionsprotein, Hyper-IL-6, nach Leberschädigung stark regenerationsfördernd wirkt. In der vorliegenden Arbeit konnte Hyper-IL-6 Expression (unterschiedlicher Höhe und Dauer) zwischen 1 ng/ml (SV40, hAAT) und 1000 ng/ml (CMV) für 1-2 Tage (CMV, …
-
Der humane lösliche Interleukin-6-Rezeptor: Reinigung aus Plasma, Charakterisierung und Nachweis der von einer alternativ gespleißten mRNA translatierten Form
… that the soluble interleukin-6-receptor (sIL-6R) can be generated by both mechanisms (resulting PC-sIL-6R or DS-sIL-6R). The sIL-6R was purified from human plasma. In a single immunoaffinity purification step a 140000-fold enrichment with a yield of 95% was achieved. The biological activity of …
-
Solid-supported synthesis of peptidoglycan fragments and their biological evaluation
… of peptidoglycan fragments containing (2S,6R)-A2pm is proposed. Thanks to a solid phase platform, cross metathesis was achieved between two easily manufactured chiral synthons, allylglycine anchored to a resin and vinylglycine derivatives. Due to the need of fragments for the study of the …
-
Synthesis, Superstructure, Vacancy-Ordering of Intercalated Transition Metal Dichalcogenides
… transition metal dichalcogenides (TMDCs) 6R-CuxTa1+yS2 and 2H-CuxTa1+ySe2, as well as the compound Cu3TaSe4. Synthesis of these compounds has been performed by the method of chemical vapor transport, using iodine as a transporting agent. X-ray diffraction may reveal superlattice …
-
The role of central IL-6 signalling in the development of Type 2 Diabetes
… a CRE-mediated nervous-system specific NesCreIL-6R knock-down (KD) mouse. Chronic administration of high-fat diet (>40% fat) in mice is commonly used to model the effects of diet-induced obesity and the progression to type 2 diabetes in humans. To examine the effects of this intervention in the …
-
Mechanism of TNF-α cytotoxicity in a leukemia virus transformation model
… to be insensitive to TNF-α and another clone (6R.1) which had an increased sensitivity to TNF-α. The differential cytotoxicity was observed when cells were treated with TNF-α, for 18 hr, at 0 to 100 units/ml, at 37°C. The mechanism of this differential cytotoxicity was further investigated. …
-
Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
… a cAMP-mediated inhibition of soluble IL-6Rα (sIL-6R)/IL-6-stimulated extracellular regulated mitogen-activated protein kinase 1, 2 (ERK1,2) and signal transducer and activator of transcription 3 (STAT3) activation in HUVECs, which was independent of cAMP-dependent protein kinase A (PKA). …
-
The Association Between Cancer-Related-Fatigue, Response to Fatigue Treatment, and Cytokines and Their Receptors, In Patients With Advanced Cancer
… and receptor antagonist (IL-1RA), IL-6, IL-6R, TNF-α and sTNF-R1 and R2, IL-8, IL-10, IL-17] levels measured by Luminex. Data were analyzed using principal component analysis (PCA) [reporting cumulative variance (variance) for the first four components] to determine their association with …
-
Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
Stimulation of the IL-6R complex leads to activation of the Jak/STAT (Januskinase/Signal Transducer and Activator of Transcription)-pathway and the Ras/Raf/MAPK-cascade. The protein tyrosine phosphatase SHP2 (SH2 - containing tyrosine phosphatase) is recruited to gp130, the signaltransducing …
-
Investigation of chemokine expression and modulation following traumatic brain injury
… and soluble interleukin-6 receptor (sIL-6R) to contusion enlargement has not been investigated. In this thesis, I investigated chemokine expression and modulation both in in-vitro, in-vivo models and in a clinical study. Initially, I compared chemokine expression in rodent and human glial …
-
Improved Synthesis, Separation, Transition Metal Coordination and Reaction Chemistry of a New Binucleating Tetraphosphine Ligand
… 4R and [rac-Rh2(nbd)2(et,ph-P4)](BF4)2, 6R, in which et,ph-P4-Ph acts as a bridging and chelating ligand. Heterobimetallic complex, NiPtCl4(rac-et,pt-P4-Ph), 5R has been prepared by reaction of rac- et,ph-P4-Ph with 1 equiv of Ni2Cl4∙6H2O, followed by dropwise addition of 1 equiv of …
-
Synthetic studies on the spiroacetal moiety of stenocarpin, a metabolite of Diplodia maydis
… established the structure as either (3S,4R,6R,7R)- or (3R,4R,6R,7R)-spiro[(4,6, 7-trihydroxy-7-methyl-8-oxo-5,6,7,8-tetrahydroisochromane)-3 ,2' -tetrahydrofuran]. The absolute configuration of the C(3) spiroacetal stereogenic center remained unknown. The aim of the synthetic studies …
-
Untersuchungen zur diastereo- und enantioselektiven Synthese von Matsuon und asymmetrische Synthese von anti-1,2-Sulfanylaminen
… part of the thesis deals with Matsuone ((2E,4E,6R,10R)-4,6,10,12-Tetramethyltridecan-2,4-dien-7-one), which is the female sex pheromone of the pine scales Matsucoccus-resinosae, M.-matsumurae and M.-thunbergianae. There are different approaches towards the diastereo- und enantioselektive …
-
Herstellung und Charakterisierung hochaffiner Inhibitoren für die Zytokine IL-6 und LIF basierend auf den Liganden-bindenden Domänen ihrer Rezeptor-Untereinheiten
… 130 (gp130) and interleukin-6 receptor alpha (IL-6R alpha), which were fused by a linker. In this work, it could be shown, that IL-6-RFP is a highly specific inhibitor which does not influence the bioactivities of the cognate IL-6-type cytokines OSM and LIF. Furthermore, a two-fold molar excess of …
-
Modulation der IL-6-abhängigen Signaltransduktion durch die Protein-Tyrosinphosphatase SHP2
… 2 (Tyk2) were stimulated with IL-6/soluble IL-6R complexes it was found that only in Jak1-, but not in Jak2- or Tyk2-deficient cells, SHP2 activation was greatly impaired. It is concluded that Jak1 is required for the tyrosine phosphorylation of SHP2, although it has been shown that all kinases …
-
Kontinuierliche Überexpression von Interleukin-6 im Zentralnervensystem : lokale Applikation d. Designerzytokins Hyper-Interleukin-6 im adulten Organismus d. Ratte u. Auswirkungen v. exzitatorischen Neurotoxinen im Interleukin-6 transgenen Mausmodell
… verbunden mit löslichem IL-6 Rezeptor (sIL-6R). Erstmalig wurden hierfür makroverkapselte, H-IL-6 exprimierende Maus-Melanomzellen (B78 Zellen) verwendet und deren Auswirkungen zwei und vier Wochen nach Implantation in das Striatum der Ratte untersucht. Deutlichstes Kennzeichen im striatalen …
Page 1 of 3