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Showing 1 to 20 of 25 for “"64Cu"”.

  1. 64Cu-bis(thiosemicarbazone) complexes for delineating myocardial hypoxia

    Handley, MaxwellKing's College London2012

    … isolated perfused hearts to screen a number of 64Cu-labelled BTSC complexes, to assess their hypoxia selectivity and accumulation in cardiac tissue. For this purpose we developed a novel incubation chamber for maintaining isolated cardiomyocytes under hypoxic conditions. We also developed a …

    kings Repository record

  2. Development of 64Cu/NOTA-terpyridine platinum conjugates as chemoradiotheranostic agents

    Khosravifarsani, MeysamUniversité de Sherbrooke2022

    … (NOTA) pour la complexation cuivre-64 (64Cu, T1/2 = 12,7 h; EC, [43.1%]; β+, 0,653 MeV [17,8%]; β−, 0,579 MeV [38,4%]). Via l'émission d'électrons Auger et de positrons, le 64Cu est une source prolifique et locale de LEE qui peut détruire sélectivement les domaines sensibles de l'ADN et …

    sherbrooke Repository record

  3. Occupational dose assessment of 64Cu-ATSM in a veterinary setting

    Hetrick, Lucas, author, Johnson, Thomas, advisor, Kraft, Susan, committee member, Biller, Barbara, committee memberColorado State University. Libraries2014

    64Cu-ATSM is an emerging radiopharmaceutical for diagnostic use in Positron Emission Tomography (PET) and has potential utility for radiation therapy but to date there are no studies that assess the occupational doses delivered to workers in either a hospital or veterinary environment. This study …

    colostate Repository record

  4. Evaluation of 64Cu-ATSM in cell culture for potential use as a radiotherapy agent

    McMillan, Dayton Datteri, author, Kato, Takamitsu, advisor, Callahan, Gerald, committee member, Kraft, Susan, committee memberColorado State University. Libraries2014

    … and more effective means to treat these tumors. 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) has shown clinical usefulness in imaging and experimental radiotherapy of solid state tumors due to its ability to concentrate in hypoxic tissue regions and emit radiations of multiple types, …

    colostate Repository record

  5. New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments

    Liu, CongDepartment of Chemical Engineering2015

    … to a maximum of 3 hours of experimental time. 64Cu is a potential candidate for PEPT tracer fabrication due to its relatively long half-life (12.7 h) which could extend the experimental running time of PEPT experiments to two uninterrupted days. The objective of the research described in this …

    cape-town Repository record

  6. Gamow-Teller strength distributions in 64Co and 64Cu studied via the 64Ni(d,2He) and 64Ni(3He, t) reactions

    Popescu, L2005

    … detector. The complementary reaction, 64Ni(3He,t)64Cu, was performed at the RCNP, Osaka, by using a 420 MeV 3He beam. The outgoing tritium particles were analyzed by the Grand Raiden Spectrometer and the RCNP detector. By the simplicity of these transitions, the strengths determined in this …

    ghent Repository record

  7. Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy

    Eiblmaier, MartinTechnische Universität Dresden

    … bifunctional chelators coupled to Y3-TATE, 64Cu-CB-TE2A-Y3-TATE had the most favorable tumor targeting properties. The introduction of ionizable linker groups could not remedy the slow clearance from the kidney, and other modifications will be necessary to resolve this issue. The emerging …

    qucosa-diss

  8. Multifunctional CuS Nanoparticles for Imaging Guided Photothermal Ablation Therapy

    Cui, LiliUniversity of Houston2015

    … A process for rapid synthesis of radioactive [64Cu]CuS nanoparticles was successfully developed in our collaborator, Dr. Chun Li’s group. Further investigation shows that [64Cu]CuS nanoparticles can act as an efficient radiotracer for PET imaging, and can be used for photothermal ablation …

    houston Repository record

  9. Biodistribution Studies of 64Cu-DOTA-Cetuximab after Intraperitoneal and Intravenous Injection in a Malignant Ascites Mouse Model of Human Gastric Carcinoma

    진, 성호2014

    … conducted a comparative biodistribution study of 64Cu-DOTAcetuximab in subcutaneous (SQ) tumor and MA mouse models. A mouse xenograft model of bilateral SQ tumors that express epidermal growth factor receptor (EGFR) was established by SQ injections of NUGC-4 and MKN-45 gastric cancer cells into …

    ajou Repository record

  10. Radiolabeled Bombesin Analogs to Improve Prostate Cancer Diagnosis by PET Imaging

    Mansour, NematallahUniversité de Sherbrooke2019

    … avec des isotopes métalliques, tel que le 64Cu, nécessite l'utilisation d’un chélateur bi-fonctionnel et d’un intermédiaire entre le chélateur et le peptide. Ces deux composants sont nécessaires pour maintenir l’activité de la bombésine. Cette thèse a pour objectif le développement des …

    sherbrooke Repository record

  11. Development of amyloid beta binding bifunctional chelators for diagnosis of Alzheimer’s disease

    Wang, YujueUniversity of Illinois at Urbana-Champaign2021

    … 11C (t1/2=20.4 min), 18F (t1/2= 109.7 min), and 64Cu (t1/2 = 12.7 h). Radiometal 64Cu has more favorable properties for amyloid imaging in terms of half-life and radiolabeling strategy. To obtain molecules that could be employed as 64Cu PET imaging agents and maintain affinity for Aβ species, our …

    uiuc Repository record

  12. Synthesis of unsymmetrical pendant-armed and phosphonic acid-pendant-armed cross-bridged tetraazamacrocycles

    Stigers, Dannon Jason

    … ionizable pendant arms. The biodistribution of 64Cu(II)&middot;51 was studied in male rats and indicated an improved blood and liver clearance and higher bone retention of 64Cu(II)&middot;51 relative to 64Cu(II)&middot;10.*.</p><p>The formation of a single pendant-armed cross-bridged cyclam is …

    unh-thes Repository record

  13. 64^Cu-bis(thiosemicarbazone) Complexes for Delineating Myocardial Hypoxia

    Handley, MaxwellKing's College London2012

    … isolated perfused hearts to screen a number of 64Cu-labelled BTSC complexes, to assess their hypoxia selectivity and accumulation in cardiac tissue. For this purpose we developed a novel incubation chamber for maintaining isolated cardiomyocytes under hypoxic conditions. We also developed a …

    kings Repository record

  14. PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION

    S. ValtortaUniversità degli Studi di Milano2010

    … recently developed, [18F]FAZA and [64Cu]ATSM at two different times, using PET and autoradiography. In parallel, an in vitro evaluation of specific hypoxic markers such as carbonic anhydrase IX and cupper transporters (Ctr-1 and ATP7B) was performed. In FaDu model we confirmed the …

    milano Repository record

  15. Developing New Methodologies for Crosslinked Polymeric Nanostructure Syntheses, Chemoselective Modifications, and Applications as Imaging and Delivery Agents

    Sun, Guorong2009

    … were functionalized with DOTA for chelating 64Cu and were then assembled into micelles and crosslinked throughout the micelle shell domain to afford the shell crosslinked nanoparticles: SCKs), containing large numbers of effective DOTAs per particle for 64Cu radiolabeling These 64Cu-complexed …

    wustl Repository record

  16. Development of Novel Macrophage Imaging Agents

    O'Neill, AlexanderKing's College London2013

    … nuclear imaging agents 99mTc-SER4, 64Cu-NOTA-SER4, and 99mTc-ED3 targeting the antigen sialoadhesin and 1111n-DTPA-ED2 targeting CD163, of which both antigens are macrophage-restricted. All the agents described herein exhibit tracking to endogenous sialoadhesin-expressing macrophage …

    kings Repository record

  17. Evaluation of new PET tracers for receptor tumour imaging

    Miranda, CecíliaUniversity of Hull2018

    … approved AMD3100 and related compound AMD3465. [64Cu]CuCB-Bicyclam was shown to bind specifically and with high affinity to CXCR4. The in vivo PET/CT imaging showed that [64Cu]CuCB-Bicyclam has excellent characteristics for imaging CXCR4 and is able to detect variations in CXCR4 receptor density. …

    hull Repository record

  18. Synthese und Charakterisierung Cyclam-basierter Multimere als Basis für Radiopharmaka

    Röhrich, AnikaTechnische Universität Dresden

    … Anwendung der Radiometallkomplexe von 64Cu oder 67Cu für diagnostische und therapeutische Zwecke äußerst interessant ist. Für eine symmetrische Mehrfachfunktionalisierung wurde auf ein Tetraamin mit Cyclamkern zurückgegriffen. Die Kupplung von vier Dansylchlorid-Einheiten war …

    qucosa-diss

  19. Entwicklung neuer radioaktiver Kupferkomplexe hoher Stabilität auf der Basis sechszähniger 3,7-Diazabicyclo[3.3.1]nonan-Derivate

    Juran, StefanieTechnische Universität Dresden

    … für einen Einsatz in der Nuklearmedizin (64Cu: Diagnostik, 67Cu: Therapie) geeignet und zwar insbesondere dann, wenn das Ligand-Grundgerüst mit zielsuchenden Biomolekülen, wie spezifischen Peptiden, Antikörpern oder Nukleinsäurebausteinen, funktionalisiert werden kann. Im Rahmen der …

    qucosa-diss

  20. Development of multifunctional compounds for the modulation and detection of amyloid beta species

    Huang, YiranUniversity of Illinois at Urbana-Champaign2021

    … employing longer-lived radionuclides such as 64Cu (t1/2 = 12.7 h, β+ = 17%, β– = 39%, EC = 43%, Emax = 0.656 MeV) are viewed as optimal PET imaging agents. Firstly, we developed a series of benzothiazole-based multifunctional compounds (MFCs) with an appreciable affinity for amyloid aggregates …

    uiuc Repository record

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