Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"6-hydroxydopamine"”.
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Factors Contributing to Weight Loss Induced by Intraventricular 6-Hydroxydopamine Lesions in Diabetes (db/db) Mice.
… produced by intraventricular infusion of 6-hydroxydopamine (6-OHDA) in the db/db mouse results in significant weight loss and decreased blood glucose levels. The purpose of this study was to examine both long and short term effects of central NE depletion in db/db mice and to evaluate some …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… that ELS increases neuronal susceptibility to 6-hydroxydopamine(6-OHDA)-induced degeneration of dopamine neurons occurs through dysregulation of the oxidative stress-related heat shock protein (HSP)25, or plasticity-related proteins, chondroitin sulphate proteoglycans (CSPGs) or Nogo-A.
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Transplantation of Mouse Embryonic Stem Cell-Derived Dopaminergic Neurons in a Unilateral 6-Hydroxydopamine Lesion Rat Model of Parkinson’s Disease
Embryonale Stammzellen (ES Zellen) sind eine vielversprechende Möglichkeit für Zellenerzatztherapie der Parkinson-Erkrankung. Undifferenzierte ES Zellen der Maus differenzieren sich zu funktionellen dopaminergen Neuronen nach der Transplantation in ein experimentellen Rattenmodell der …
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A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in <i>C. elegans</i>
… neurons from oxidative stress inflicted by 6-hydroxydopamine (6-OHDA) uptake and isolated the neuroligin-like gene <i>glit-1</i> and the transthyretin-related gene <i>ttr-33</i>. Neuroligins are transmembrane proteins involved in the development and function of synapses. We provide evidence …
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Tumor Necrosis Factor Dependent Mechanisms and Neuroprotective Strategies in Models of Parkinson's Disease
… tumor necrosis factor inhibitor reduced 6-hydroxydopamine-induced nigral degeneration by 50% and attenuated amphetamine-induced rotational behavior, indicative of striatal dopamine preservation in a rodent model of Parkinson's disease. Similar protective effects were observed with in vivo …
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Exercise induced neuroprotection in spontaneuosly running rats
… neuroprotection after unilateral lesions with 6-hydroxydopamine. Rats were divided into runners (had access to running wheel) and non-runners (their running wheels were immobilised). Two weeks after injection of the neurotoxin, the rats were injected with apomorphine and the number of ipsilateral …
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The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease
… of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA.
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Role of Dopamine of Nucleus Accumbens In Behavioral Sensitization to Methylphenidate
… destroyed using catecholamine neurotoxin 6-hydroxydopamine (6-OHDA). In order to determine whether destruction of dopaminergic afferents of the NAc prevents sensitization, I compared locomotor activity in rats that had received infusions of 6-hydroxydopamine (6-OHDA) into the NAc with that …
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Progress Towards Understanding Of Mechanisms Of Action Of Potent Multifunctional Disease Modifying Therapeutics For Parkinson's Disease & Investigating The Methamphetamine-Induced Striatal Microglia Activation.
… the ability of D-512 to rescue against 6-hydroxydopamine induced cell death in dopaminergic cell line PC12 under two different protocols. Once it was established that D-512 is able to prevent/rescue the cell death induced by 6-hydroxydopamine in PC12 cells, various other assays to …
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Effects of dopamine depletion in the nucleus accumbens on lateral hypothalamic self-stimulation in the rat
… the effects of dopamine depletion induced by 6-hydroxydopamine (6-OHDA) on lateral hypothalamic (LH) self-stimulation using within-subject analysis. To minimize motor deficits due to destruction of the dorsal striatal dopaminergic input, I made multiple injections of 6-OHDA (totaling 9.6 og/6 …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
… to be activated and cleaved in response to 6-hydroxydopamine (6-OHDA), a neurotoxin frequently used to mimic oxidative stress in dopaminergic neurons. Furthermore, the pretreatment of dopaminergic neurons with a ligand-blocking antibody specific for the extracellular domain of p75NTR (α- p75 …
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Synthetic and metabolic studies on centrally acting amines
… of the neurotoxicological properties of the 6-hydroxydopamine analog 2-methylamino-1-(2,4,5-trihydroxyphenyl) propane and its possible precursor intermediate 1-(2-hydroxy-4,5-methylenedioxyphenyl)-2-methylaminopropane, potential metabolites of the serotonergic neurotoxin 2-methylamino- …
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Neuroprotective Effects of FGF20 on Dopamine Neurones
… culture system and a partially lesioned 6-hydroxydopamine (6OHDA) rat model of Parkinson’s disease (PD) were established in which FGF20 was evaluated for its neuroprotective effects both in vitro and in vivo. Using immunohistochemistry, FGF20 and at least three of its receptors (fibroblast …
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Sympathetic Innervation of the Rat Adrenal Cortex and Its Effects on the Compensatory Adrenal Cortical Growth Response to Unilateral Adrenalectomy (Catecholamine, Endocrine, Splanchnic Nerve, Cell Proliferation)
… neonatal sympathectomy with guanethidine or 6-hydroxydopamine, but unaffected by splanchnic nerve ligation or suprarental ganglion extirpation. Sympathetic innervation was shown to mediate compensatory adrenal cortical growth, a cell proliferation response which occurs in the remaining adrenal …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… of the HDAC-Is were then assessed in the 6-hydroxydopamine- and LPS-lesioned mouse models of PD. Both SAHA and VPA protected dopaminergic neurones and decreased the number of astrocytes in substantia nigra pars compacta (SNpc), although the number of active microglial cells were not reduced …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… significant cytoprotection against H2O2- and 6-hydroxydopamine- (6-OHDA) induced cell death. Further, DJ-1, a multifunctional protein, was selected for investigation with SFN, since it is highly implicated with neuronal cell health. SFN induced DJ-1 protein levels dose-dependently. In addition, …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
… Using the microdevice, the effects of 6-hydroxydopamine: 6-OHDA), one of the most commonly used toxins for modeling PD, on axonal transport was then investigated on GFP labeled midbrain neurons cultured within the microdevice. 6-OHDA quickly induced mitochondrial transport dysfunction in …
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Investigating the role of neuroinflammation in a mouse model of L-Dopa induced dyskinesia and exploring the anti-dyskinetic potential of a cannabinoid receptor agonist
… To achieve these aims we utilized the 6-hydroxydopamine (6-OHDA) mouse model that recapitulated the cardinal behavioral and pathological features of both PD and LID. We first conducted a time course of neurodegeneration following the injection of the neurotoxicant 6-OHDA into the medial …
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The Role of ERK5 in Dopamine Neuronal Survival
… human dopaminergic SH-SY5Y cells against 6-hydroxydopamine (6-OHDA)-induced toxicity at 24 h. However, GDNF or DNSP-11 pretreatment protected against 6-OHDA-induced increase in apoptotic signaling, as measured by caspase-3/7 activity at 6 h; indicating that GDNF and DNSP-11 blocks some, but …
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Impact of N-Acetyl-L-Cysteine on the Pathology of Experimental Parkinson’s Disease in Vivo
… oxidative and/or proteotoxic stress: the 6-hydroxydopamine (6-OHDA) model of dopaminergic neurodegeneration and the alpha-synuclein model of Lewy-like pathology. NAC offered only transient protection in the 6-OHDA model, as demonstrated by multiple histological techniques that were validated …
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