Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"6-OHDA lesions"”.
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Effect of medial prefrontal cortex 6-OHDA lesions on behavioral and neurochemical responses to gustatory stimuli
… challenges of the system. In fact, 6-OHDA lesions of the mPFC have been shown to produce sensitization to the neurochemical and behavioral responses to cocaine and to alter the NAc DAergic transmission in response to natural reinforcers. In the present thesis it was studied the effect …
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Factors Contributing to Weight Loss Induced by Intraventricular 6-Hydroxydopamine Lesions in Diabetes (db/db) Mice.
… infusion of 6-hydroxydopamine (6-OHDA) in the db/db mouse results in significant weight loss and decreased blood glucose levels. The purpose of this study was to examine both long and short term effects of central NE depletion in db/db mice and to evaluate some of the behavioral …
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The crossed mesostriatal pathway and circling behaviour in rats
Rats with unilateral 6-OHDA lesions of the nigrostriatal (NS) projection display motor asymmetry in the form of rotational behaviour. The rotation is in the direction ipsilateral with respect to the lesioned side (Ungerstedt 1979). The nett ipsilateral rotations decrease with time, from 1 week to …
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Characterizing the modulation of mGluR5 in a 6-OHDA-induced rat model of Parkinson's disease
… of mGluR5 function in a 6hydroxydopamine (6-OHDA) induced rat model of PD. Unilateral 6-OHDA lesions were made in the right medial forebrain bundle, and severity of these lesions was determined with [¹¹]CFT. The binding characteristics of the PET ligands were analyzed using a modified …
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Role of Dopamine of Nucleus Accumbens In Behavioral Sensitization to Methylphenidate
… catecholamine neurotoxin 6-hydroxydopamine (6-OHDA). In order to determine whether destruction of dopaminergic afferents of the NAc prevents sensitization, I compared locomotor activity in rats that had received infusions of 6-hydroxydopamine (6-OHDA) into the NAc with that of control and …