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Showing 1 to 2 of 2 for “"6-Deoxyerythronolide B"”.
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STRUCTURE DETERMINATION, BIOCHEMICAL CHARACTERIZATION, AND PROTEIN ENGINEERING OF THE ACYL CARRIER PROTEIN DOMAIN FROM 6-DEOXYERYTHRONOLIDE B SYNTHASE
… are an important class of natural products. 6-Deoxyerythronolide B Synthase (DEBS) is a type 1 polyketide synthase that produces the Polyketide antibiotic drug erythromycin. DEBS is a large multi-domain enzyme complex containing multiple enzymatic domains, including acyl carrier protein (ACP). …
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C—H oxidation reactions in complex molecule synthesis: application and development
… oxidation strategy in the total synthesis of 6-deoxyerythronolide B (6-dEB), the aglycone precursor to the erythromycin antibiotics. An advanced intermediate is cyclized to the 14-membered macrocyclic core of 6-dEB using a late-stage (step 19 of 22) C–H oxidative macrolactonization reaction that …