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Showing 1 to 11 of 11 for “"6 - Mercaptopurine"”.
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Risk of malignancy in patients with inflammatory bowel disease treated with Azathioprine or 6-mercaptopurine : the Cape Town experience
… use of Azathioprine (AZA) and its metabolite 6-mercaptopurine (6-MP) in the treatment of Inflammatory Bowel Disease (IBD) are well established. However, concern regarding the long-term use of these agents in the induction of certain malignancies particularlty lymphoma and skin cancer has been …
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ΜΕΛΕΤΗ ΣΥΠΛΟΚΩΝ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5' - ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ
… OF METAL IONS WITH ADENOSINE MONOPHOSPHATE, 6-MERCAPTOPURINE AND ITS RIBOSIDE - ANTICANCER DRUGS - AND 8-AZAPURINES IS INVESTIGATED. WE HAVE PREPARED THE COMPLEXES OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. THE METAL TO LIGAND RATIO …
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Lymphocytopenia in patients with inflammatory bowel disease on immunosuppressive medications
Azathioprine and 6-mercaptopurine (AZA/6MP) are effective immunosuppressives commonly used for the treatment of inflammatory bowel disease (IBD). The mercaptopurine metabolites, 6-thioguanine (6TG) and 6-methylmercaptopurine ribonucleotides (6MMP), have been suggested as surrogate markers of the …
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Studies in the Folate Metabolism of Rats
… reductase. In view of this, the effects of 6-mercaptopurine, a classical purine inhibitor, on folate metabolism were studied. In addition to the characterization of urinary metabolites, an effort was made to identify the nature of metabolites present in the liver throughout the experiments. …
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Screening for purine transporters in S. aureus
… the pharmacological agents methotrexate and 6-mercaptopurine and supplementing inosine monophosphate and/or guanine as an exogenous purine source. I identified an ATP-Binding Cassette transporter mutant that failed to grow under the selective purine transport conditions. Further growth …
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In vitro studies on genotoxicity and gene expression in spermatogenic cells: mechanisms and assay development
… N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, 6-mercaptopurine, 5-bromodeoxyuridine, methyl methanesulphonate and ethyl methanesulphonate were investigated. Cells were cultured and treated with different concentrations for each agent. DNA damage and apoptosis were measured by Comet and TUNEL …
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Chemical synthesis of DNA and RNA containing thio-substituted bases and their post-synthetic modifications
… was first discovered as metabolic compound of 6- mercaptopurine (6-MP). Later, it was applied as drug to cure leukaemia. During the research of its toxicity, a method was developed to use the sulphur group as a versatile position for post-synthetic modification. The advantage of application of …
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The ground and excited state molecular structure of model systems undergoing photochemical processes and the characterization of active agents by means of vibrational spectroscopy and theoretical calculations
… of two related anti-leukemia active agents, 6-mercaptopurine (6MP) and 6-mercaptopurine-ribose (6MPR) on a silver colloid. Both molecules adsorb through the N1 and possibly S atom on the metal surface under basic conditions. The SERS spectra recorded for acidic pH values showed that the ribose …
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Study of the chemotherapy of leukaemia
… folic acid analogues and the purine analogue 6- mercaptopurine, resulted in dramatic 'remissions in patients with acute leukaemia, but with the aid of modern scientific techniques information has been obtained relating to their mode of action In addition their importance as a stimulus to research …
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Culturally Informed Motivational Interviewing to Improve Oral Chemotherapy Adherence for Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers: A Feasibility, Acceptability, and Preliminary Efficacy Trial
… phase wherein patients must take daily oral 6-mercaptopurine (6-MP). 6-MP regimen adherence is challenging and failure to take medication has been associated with an increase in relapse risk. Accordingly, interventions that enhance 6-MP adherence during ALL maintenance chemotherapy may result …
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Effect of obesity on hepatic drug metabolism
… provides a potential mechanism of altered 6-mercaptopurine exposure in the obese pediatric cancer population. While clinical studies would provide the most optimum method to predict clearance of therapeutic agents in humans, studies have reported that clearance can also be predicted using …