Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"5xFAD"”.
-
Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD
… Arbeit wurde das doppelt transgene Mausmodell 5XFAD von Oakley und Kollegen mit fünf humanen EOAD-Mutationen (early-onset Alzheimer´s disease), welches drei APP-Mutationen (Amyloid Precursor Protein) und zwei PS1-Mutationen (Presenilin-1) beinhaltet, erstmals quantitativ mittels stereologischer …
-
Neuromuscular Dysfunction as a Novel Indicator for Alzheimer's Disease and Response to Intervention in the 5xFAD Model
… to exercise in an AD-like context using 5xFAD mice, an AD model developing early pathology and cognitive impairments around 6 months of age. We examined in vivo neuromuscular function in both muscle and the sciatic nerve, and exercise adaptations (mitochondrial respiration and RNA …
-
Cognitive and Non-Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease
… had minor effects on the performance of 5xFAD mice in the 5-CSRTT, a touchscreen task evaluating attention. Additionally, 5xFAD mice do not demonstrate impairments in the PVD task, which assesses visual discrimination/ cognitive flexibility. However, the parameters recorded by the …
-
Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
… examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and compared their whole- and phosphoproteomes with human AD (the integration of three published datasets) to study whether they can mimic protein/RNA expression discrepancies, molecular changes, and …
-
A Multi-Faceted Approach to the Alzheimer’s Disease Proteome: From Human to Mouse Models
… consistently shared between human AD and the 5xFAD and APPNL-G-F mouse models, including amyloid regulation, nitric oxide regulation, superoxide regulation, cell, adhesion, and cellular component organization. Finally, we investigated global proteome turnover changes in 5xFAD mice to shed …
-
Epigenetics of Neurodegeneration: Quantification of Histone Deacetylase Isoforms and Post-translational Modifications of Histones in Alzheimer’s Disease
… degeneration, and whole brain hemisphere of a 5XFAD mouse model of AD. Histone deacetylases are enzymes responsible for the deacetylation of histones, which can directly regulate transcription, and have been implicated in AD pathology. In addition to measuring isoforms of histone-modifying …
-
Gamma frequency entrainment attenuates amyloid load and modifies microglia
… we investigated this relationship using the 5XFAD mouse model of Alzheimer's disease (AD) and found reduced behaviorally driven gamma activity before the onset of plaque formation or evidence of cognitive decline. Because of the early onset of gamma deficits, we aimed to determine if …
-
Clearance systems at brain borders
… of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer’s disease, which was associated with increased aquaporin-4 polarization along astrocytic endfeet, dilated meningeal lymphatic vessels, and amyloid accumulation in cervical lymph nodes. Inhibiting glymphatic clearance …
-
Análises de redes modulares de co-expressão gênica revelam vias importantes na doença de Alzheimer e paralisia supranuclear progressiva
… Supranuclear Palsy) and two animal models, 5XFAD of amyloidopathy and TauD35 of tauopathy, we performed an integrative analysis at the gene/transcript level combined with a co-expression analysis to identify similarities and discrepancies in the biological processes affected by these two …
-
KLK6 modulates Αβ plaque accumulation in a mouse model of Alzheimer's disease
… του ρόλου της, διασταυρώσαμε το μοντέλο AD 5xFAD με μύες με απουσία έκφρασης του γονιδίου KLK6, δημιουργώντας μια νέα αποικία (5xFADKlk6-/-), και συγκρίναμε τον αριθμό των Aβ πλακών σε εγκεφαλικές τομές του ιπποκάμπου με τη χρήση ανοσοϊστοχημείας στις ηλικίες 2,5, 4 και 10 μηνών. Και οι δύο …
-
Quantitative Analysis of Retinal Vascular Morphology and Dynamics Using Optical Coherence Tomography
… ratio (WLR). Comparative analysis in control and 5xFAD mice established WLR as a sensitive marker of Alzheimer’s disease condition. The second aim focuses on dynamic vascular assessment using Doppler OCT. While traditionally used to measure blood flow, we extended its application to capture …
-
Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition
… reduced amyloid load in AC and hippocampus of 5XFAD mice. These changes in activation responses were evident in microglia, astrocytes, and vasculature. Additionally, auditory GENUS reduced phosphorylated tau in the tau P301S model. Finally, I demonstrate that combined auditory and visual GENUS, …
-
Investigating state-dependent pontine cholinergic activity during REM sleep and P-waves in vivo
… sleep disturbances were more profound in aging 5XFAD mice, a mouse model of AD, compared to controls. It is concluded that cholinergic PPT/LDT activity coincides with REM sleep initiation and P-waves, however functional studies are required to determine the causal relationship for both phenomena.
-
Developing EasySci, a High-Throughput and Low-Cost Single-Cell Genomic Technique, to Study Aging and Alzheimer's Disease in Human and Mouse Brain
… cell population dynamics reminiscent of the 5xFAD early-onset model. This suggests the novel model's potential utility in Alzheimer's disease research. For instance, the expansion of septal nuclei neurons were observed in both models. This neuron subtype had increased axonogenesis gene module …
-
Development of multifunctional compounds for the modulation and detection of amyloid beta species
… the Aβ binding specificity of the probes, 5xFAD brain sections were stained with the developed sensors. As expected, if the brain sections are only stained with the compounds, the fluorescence images show that the sensor has poor ability to detect amyloid plaque with low fluorescence …
-
Using Genetic Diversity to Understand Susceptibility to Cognitive Decline in Aging and Alzheimer’s Disease
… of AD harboring 5 familial AD mutations, the 5XFAD model. The resulting panel, which we termed the AD-BXDs, consists of genetically diverse yet isogenic Fl mice that all harbor the same high-risk human AD mutations but who differ across the remainder of their genome. We first showed that …