Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"5-hmC"”.
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Functional analysis of 5-hydroxymethylcytosine
… modified cytosine, 5-hydroxymhetylcytosine (5-hmC), was identified and found at significant levels in mouse brain and both mouse and human embryonic stem (ES) cells. The conversion of 5-mC to 5-hmC is catalyzed by the ten-eleven translocation (TET) proteins of the 2-oxoglutarate (2OG)-and …
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The HLA Complex Group 9 Gene Modification Study in Major Psychosis
… (5-mC) and 5-hydroxymethylcytosine (5-hmC) in neural and non-neural tissue from mice and humans. 5-hmC has been recently found to be abundant in brain but its function is poorly understood. We assayed 5-hmC by using glucosylation coupled with restriction enzyme digestion and microarray …
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… pathway, 5- hydroxymethylcytosine (5-hmC) is an epigenetic marker that significantly influences gene expression, with major consequences for embryonic development, stem cell identity, and ultimately organ homeostasis. Keratinocyte stem cells (KSC) maintain a healthy skin barrier by …
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… to initiate HCC. 5-hydroxymethylcytosine (5-hmC), recently identified sixth base of the genome, can cause demethylation by its conversion to cytosine through reactions catalyzed by the TET enzymes. Research on the role of this novel modification in the liver and HCC is needed before it can be …
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… phenotype. Further, DNA 5-hydroxymethylation (5-hmC) is one type of DNA methylation that is 10 times more abundant in the brain than peripheral tissues. However, to date, no study has been conducted examining whether DNA 5-hmC becomes altered in the brain following weight gain and/or contributes …
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The Role of Dna Methylation and Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis
… to altering key components of the mTOR-TET2-5-hmC pathway and thereby lead to novel therapeutic targets for treating disease.</p>
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… this region to a 5-hydroxymethylation (5-hmC) state that increase gene transcription. Remarkably, this manipulation led to improved memory retention in aged, but not middle-aged, rats. We next showed that baseline levels H2Bubi decrease with age in the hippocampus of male rats. Again, we …
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Regulation of nucleosome dynamics
In eukaryotic cells, the genome is packed into fundamental units called nucleosomes, where 147 base pairs of DNA are wrapped around a protein core. Stable packing of DNA in nucleosomes imposes a barrier for accessibility of genetic code on DNA for replication, transcription, and repair. The …