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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"5-aza-2"”.

  1. The Analysis of the MCF7 Cancer Model System and the Effects of 5-AZA-2'-Deoxycytidine Treatment on the Chromantin State Using a Novel Microarray-Based Technology for High Resolution Global Chromatin State Measurement

    Weil, Michael RyanUT Southwestern Medical Center2006

    … demonstrated in a MCF7 cell line treated with 5 Aza dC, which disrupts genome methylation, and as a result causes global relaxation of chromatin structure. 5 Aza dC treatment results in strong changes in expression, and a normalized global chromatin relaxation of two-fold. A significant subset of …

    utswmed Repository record

  2. Epigenetische Beeinflussung der Proliferation, Expression von Matrix-Metalloproteinasen, Migration und Invasion von Harnblasenkarzinomzelllinien

    Kosz, Magdalena2012

    … mit nicht-methylierbaren Cytosinanaloga, wie 5-aza-2 -deoxycytidin und Histondeacetylaseinhibitoren wie Trichostatin A, stellen potenzielle therapeutische Optionen für die Behandlung maligner Tumoren dar. In dieser Studie wurde deren Wirkungsweise an vier biologisch unterschiedlichen …

    goettingen Repository record

  3. Studies On The Determinants Of HIV Mutagenesis And Strategies For Its Enhancement

    Rawson, Jonathan2015

    … in the absence of mutational hotspots; 3) 5-azacytidine causes HIV-1 mutagenesis after reduction to 5-aza-2’-deoxycytidine (i.e. decitabine); 4) the anti-HIV-1 activity of 5-azacytidine is antagonized by inhibitors of ribonucleotide reductase; 5) the anti-HIV-1 activity of ribonucleotide …

    umn Repository record

  4. Exposures and the Impacts on the Epigenome that Persist from Youth to Adulthood and Intergenerationally

    Colwell, Mathia2022

    … arsenic and the chemotherapeutic drug 5-aza-2'-deoxycytidine (Decitabine), both of which disrupt different elements of the DNA methylation pathway resulting in persistent epigenetic changes. I first share my findings on the impacts of maternal arsenic exposure, which disrupts the 1-carbon …

    umn Repository record

  5. Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies

    Patil, VibhaUNSW, Sydney2015

    … in cancer. DNA hypomethylating agents such as 5-Aza-2’deoxycytidine (5-Aza-dC) are approved for the treatment of myelodysplastic syndrome and show promise in the treatment of solid tumours. These therapies are thought to exert their anti-tumour effects by reactivating hypermethylated genes. …

    unsw Repository record

  6. Analyse des in vivo Differenzierungspotentials humaner leukämischer Zellen sowie humaner und muriner neuraler Stammzellen

    Dürr, MichaelUniversität Würzburg

    … in vitro mit Trichostatin A (TSA) und 5’-Aza-2’-deoxycytidin (AzaC)inkubiert und anschließend in murine Blastozysten bzw. adulte NOD/SCID Mäuse transplantiert. In dem Versuchen konnte gezeigt werden, dass humane leukämische Zellen nach Injektion in murine Blastozysten in sich entwickelnden …

    wurz-thes Repository record

  7. Pathway Profiling Of Replicative And Induced Senescence

    Purcell, Maggie2014

    … by using various drugs to induce senescence: 5-aza-2-deoxycytidine (a demethylating agent), Adriamycin (a chemotherapeutic drug), and H2O2 (an agent causing oxidative stress).</p> <p>MDAH041 cells, which are fibroblasts isolated from a patient with Li Fraumeni Syndrome, have heterozygous alleles …

    wayne-thes Repository record

  8. p53 acts to prevent the formation of pathological R-loops during epigenetic stress

    Hands, Emma LangdaleUniversity of Cambridge2023

    5-Azacytidine (Aza) and 5-Aza-2’-deoxycytidine (Dac) are the two primary therapeutics for the treatment of Acute Myeloid Leukaemia and some myelodysplastic syndromes. The two are frequently used interchangeably, surprisingly as their selectivity of de-methylation is unique from the other, however …

    cambridge Repository record

  9. Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis

    Silvestre, Katherine JMassachusetts Institute of Technology2014

    … A novel antiviral nucleoside analog, 5-Aza-5,6-dihydro-2'- deoxycytidine (KP1212), employs the mechanism of lethal mutagenesis to avoid the problem of drug resistance and use the virus's high mutation rate against it. KP1212 is incorporated into DNA by HIV reverse transcriptase (RT) but …

    mit Repository record

  10. Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie

    Cabral do Ó, Nicole TâniaPublikationsserver der RWTH Aachen University2009

    … Clinical trials with demethylating agents as 5-aza-2’-desoxycytidine (DAC) und 5-azacytidin (AZA) provided promising findings in therapy of acute leukemias and myelodysplastic syndrome (MDS). We showed, that in hematopoietic tumor cell lines, CpG island hypermethylation of the proximal C/EBP …

    aachen Repository record

  11. Chronic oxidative stress and susceptibility to renal carcinogenesis

    Mahalingaiah, Prathap Kumar SalakatteTexas Tech University2015

    … in epigenetic regulatory proteins and 5-aza 2' dC induced decrease in growth and tumorigenic potential further suggested possible role of DNA hypermethylation in chronic oxidative stress induced changes. Increased growth and tumorigenic potential of Caki-1 cells with up-regulation of …

    ttu Repository record

  12. Functional consequences of cytosine methylation in mitochondrial DNA catalyzed by DNA methyltransferase 1

    Shock, Lisa2016

    … inhibition by the nucleoside analog 5-aza-2’-deoxycytidine (5-aza-dC). NRF1 and PGC1α, transcription factors that activate nuclear-encoded mitochondrial proteins in response to oxidative stress, were observed to up-regulate expression of mtDNMT1. Loss of p53, a tumor suppressor gene …

    vcu Repository record

  13. Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia

    Scott, Stuart AlexanderUniversity of Saskatchewan2005

    … p15 mRNA. Treatment with the cytosine analog 5-Aza-2’-deoxycytidine (5-Aza-dC) in vitro resulted in promoter demethylation and p15 mRNA re-expression, which was associated with a release of a transcriptionally repressive complex at the p15 promoter. Importantly, 5-Aza-dC treatment also reversed …

    sask Repository record

  14. Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart

    Patterson, Andrew James Grant

    … the presence of the DNA methylation inhibitor, 5-aza-2-deoxycytidine, binding of SP1 to PKCε promoter, promoter methylation, and PKCε protein and mRNA were restored to control levels. Connecting epigenetics to chronic hypoxia in utero led us to further investigate the underlining mechanism of …

    loma-linda Repository record

  15. Regulation of Matrix Metalloproteinases and Their Inhibitors by DNA Methylation in Human Gestational Tissues

    Vincent, ZoeResearchSpace@Auckland2013

    … were treated with the demethylating agent 5-aza-2'-deoxycytidine (AZA) and/or lipopolysaccharide (LPS). qRT-PCR and western blotting revealed synergistic up-regulation of MT1-MMP and TIMP-1, by combined AZA+LPS treatments. Secreted MMP-2 and -9 activities were evaluated by gelatin zymography …

    auckland-ms Repository record

  16. CANCER-RELATED GENE REGULATION MECHANISMS

    Veerla, SrinivasDepartment of Clinical Genetics, Lund University2008

    … bladder cancer cell lines with the drug 5-aza-2’-cytidine that specifically inhibits methylation and thereby reactivates methylated promoters. Our major finding is that many genes shows patchy promoter methylation patterns that frequently affect high scoring and evolutionarily conserved …

    lund Repository record

  17. Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie

    Schmid, JuliaPublikationsserver der RWTH Aachen University2010

    … of KG1a and HL60 with the demethylating agent 5-aza-2’deoxycytidine led to a reexpression of SFRP-1 and SFRP-2 in real-time RT-PCR analysis. By MSP, we analyzed the methylation status of SFRP-1,-2,-4 and -5 in 97 specimens obtained from AML patients at diagnosis. The frequencies of aberrant …

    aachen Repository record

  18. COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS

    SUN FENG2010

    … through inducing cancer cell apoptosis. 3-deazaneplanocin A (DZNep) appears to be a unique chromatin remodelling (epigenetic) compound that can deplete the cellular enhancer of zeste homolog 2 (EZH2) protein, an enzyme responsible for modulation of histone methylation and in turn specifically …

    nus Repository record

  19. A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies

    Hennessey, Violeta G2010

    … was declared for DNA methylation inhibitor, 5-AZA-2'-deoxycytidine combined with one histone deacetylation inhibitor, suberoylanilide hydroxamic acid or trichostatin A in the cell lines HEY and SKOV3. This suggests potential new epigenetic therapies in cell growth inhibition of ovarian cancer …

    uthsc Repository record

  20. The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme

    Ahmed, AqibUniversity of Bradford2022

    Epigenetic mechanisms play an important role during the morphogenesis of the hair follicle and the hair cycle. Work on hair regeneration is of importance as no products are available which can provide complete reversal of hair loss. Tet2 promotes DNA demethylation by the hydroxylation of 5mC to …

    bradford Repository record

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