Global ETD Search
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Showing 1 to 9 of 9 for “"5-aminolevulinic acid"”.
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Protoporphyrin IX distribution in rat brain following the administration of 5-aminolevulinic acid and its hexylester
… intra-cranially with varying concentrations of 5-aminolevulinic acid (10, 20, 99, 199, 398 mM) and its hexylester (6.6, 13, 66, 132, 265 mM). Toxicity effects of these compounds were examined based on animal behavior and respiratory distress. It was determined that the maximum tolerable dose for …
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Histological Changes in Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in a Photoaged Mouse Model
… specimens after photorejuvenation induced by 5-aminolevulinic acid (ALA)-PDT. Furthermore, I investigated transmission electron microscopic (TEM) studies to observe the differences among normal, photoaged, and post-ALA-PDT biopsy specimens. Materials and Methods: Total 32 of 6-week-old female …
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Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in the Patients with Actinic Keratosis: A Histological Analysis
… Objectives: I investigated whether 5-aminolevulinic acid (ALA)-PDT induced histological changes suggesting photorejuvenation. Materials and Methods: Fourteen patients with one to three actinic keratosis on the face were treated twice with ALA-PDT using a 1200W metal halogen lamp at one …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
… accumulated in glioma cells with exogenous 5-aminolevulinic acid (5-ALA) serves as contrast agent for fluorescence-guided surgery and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and …
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Investigation on the Intracellular Sognal Transduction Mechanism of Human Dermal Fibroblasts of Photorejuvenation in Photodynamic Therapy
… various sublethal and relatively low doses of 5-aminolevulinic acid (ALA) and red light. The inhibition of fibroblast proliferation was not observed at the ALA concentration of 0.1mM, ALA incubation time of 30 minutes, and 3 J/cm2 of red light energy. In this condition, I found that a small …
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Catalytic promiscuity of two plant P450 enzymes: CYP725A4 from Taxus cuspidata and CYP71B102 from Isatis Tinctoria
… terrific broth (TB) medium in combination with 5-aminolevulinic acid supplementation and isatin hydrolase coexpression altogether increased indigo formation, while supplementation with isatin and 2-oxindole increased indirubin formation. The results of this study showed that the catalytic …
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OPTIMIZED APPROACHES FOR LIQUID BIOPSY IN GLIOBLASTOMA PATIENTS
… biopsy: plasma extracellular vesicles (EVs), 5-aminolevulinic-acid (5-ALA)–induced protoporphyrin IX (PpIX) fluorescence, and focused-ultrasound blood–brain-barrier opening (FUS-BBBO). The objective is to determine whether they can aid in collecting accurate, real-time information on tumour …
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Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
… cells regardless of phenotype. </p><p>First, 5-aminolevulinic acid (ALA) was incubated with cells causing an increased cellular production of the heme prequel, protoporphyrin IX (PpIX). In cancer cells, the production of PpIX is higher and allows for detection from normal after a 2 hour …
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Clinical study of the use of Photodynamic Detection (PDD) in assessing suspicious oral lesions
… fluorescence intensity peaks. In this study 5-aminolevulinic acid (5-ALA) photosensitizer prodrug was used, which is metabolised in highly active cells to protoporphyrin IX (PpIX). Excitation of a cell at 405nm wavelength (light) leads to emission of autofluorescence at 500nm and PpIX at 635nm. …