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Showing 1 to 6 of 6 for “"5-alpha-reductase"”.

  1. The Role of 5-Alpha Reductase 3 In Steroid Metabolism

    mitri, zahi2016

    … driven by androgen mediated signaling. The 5-alpha reductase family of enzymes plays an essential role in the conversion of testosterone to the more potent androgen, 5-alpha dihydrotestosterone (DHT), which is capable of binding the androgen receptor to activate gene targets and downstream …

    uthsc Repository record

  2. Regulation of Expression of 5 Alpha-Reductase Type 1 in Mouse Leydig Cells

    Krishnan, Shruti2010

    … in the testis of most species. The enzyme 5a-reductase converts circulating testosterone to dihydrotestosterone in target tissues, a process that is necessary for development of the male phenotype in human beings. However, in some animals, androstanediol, a 5a-reduced androgen, is the primary …

    utswmed Repository record

  3. Combination of Dietary Tomato and Broccoli Powders Are Effective Growth Inhibitors of Dunning R3327-H Prostate Adenocarcinomas

    Adams, Kirstie Anne-MerreaUniversity of Illinois at Urbana-Champaign2015

    … significantly decreased expression of 5-alpha-reductase-II, Bcl-2, and IL-6 in tumors. IL-6 was reduced in high lycopene and broccoli, P=0.05, and TNF-alpha was lower with low lycopene, P=0.05. Overall, the combination of tomato and broccoli powders was more effective at slowing tumor …

    uiuc Repository record

  4. Ruolo dei neurosteroidi nella modulazione dopaminergica

    PES, ROMINAUniversità degli Studi di Cagliari2015

    … we have characterized that inhibition of 5 alpha- reductase (5AR), the key enzyme for androgen metabolism and neurosteroid synthesis, elicts antidopaminergic effects. The 5AR inhibitor, finasteride (FIN), is currently approved for the therapy of benign prostatic hyperplasia and androgenic …

    cagliari Repository record

  5. The effect of Finasteride in Tourette Syndrome: results of clinical trial

    PABA, SILVIAUniversità degli Studi di Cagliari2011

    cagliari Repository record

  6. Pharmakokinetik und Biokonversion von Dehydroepiandrosteron nach Dexamethason-Vorbehandlung bei Frauen mit dem Syndrom der polyzystischen Ovarien

    Schlenz, NadineUniversität Würzburg

    … die Anstiege bei den PCOS-Frauen für 5alpha-Dihydrotestosteron (DHT) (P < 0,01) und dessen Hauptmetaboliten 5alpha-Androstan-3alpha,17beta-diol-17-Glucuronid (ADG) im Serum (P < 0,05) sowie für den 5alpha-reduzierten Androgen-Metaboliten Androsteron im Urin (P < 0,05) signifikant höher. …

    wurz-thes Repository record