Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"5-Lipoxygenase"”.
-
La caractérisation de l'isoforme △13 de la 5-lipoxygenase humaine
"La 5-lipoxygenase (5-LO) est une enzyme importante dans le fonctionnement normale de la réponse inflammatoire et sa dérégulation est associée à plusieurs maladies. La 5-LO catalyse la biosynthèse des leucotriènes (LTs) à partir de l'acide arachidonique (AA), un acide gras polysinsaturé. …
-
Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium
… interleukin-6 (IL-6) in vascular endothelium. 5-Lipoxygenase (5-LOX) is one of the key sources that generate reactive oxygen species (ROS) via metabolic pathways of arachidonic acid. Although 5-LOX has been implicated in the development of atherosclerosis, it remains unclear whether …
-
Effects of 5-Lipoxygenase Activating Protein Inhibitor on Abnormal Alveolarization and Lung Development Induced by 85% Oxygen Exposure in Newborn Mice Model
… 85% 산소에 노출된 신생 마우스 모델에서 leukotriene 합성 억제 물질인 5-lipoxygenase activating protein (FLAP) inhibitor 투여로 비정상적 폐포화 과정을 예방할 수 있으리라는 가설하에 연구를 진행하였다. 방법: 출생 후 12시간 이내의 신생 마우스를 대기노출(RA)군과 고농도산소노출(OX)군으로 나누어 각각 21% 산소와 85% 산소에 14일간 노출시켰다. 각 군 내에서 소집단으로 세분하여 FLAP inhibitor로 알려진 MK-0591을 각각 0, 10, 20, 또는 40 …
-
La lignée monocytaire Mono Mac 1 différentié par le lipopolysaccharide est un bon modèle cellulaire pour l'étude du métabolisme des acides gras polyinsaturés et de la 5-lipoxygenase
"Le but de projet est d'établir la lignée monocytaire Mono Mac 1 (MM1) comme modèle pour l'étude du métabolisme des acides gras polyinsaturés (PUFA) et de l'activité transcriptionnelle des différents polymorphismes du promoteur de la 5-LO."
-
The effects of jasmonates on the proliferation of human prostate cancer cell lines in culture
… The mechanism of inhibition was studied using 5-lipoxygenase enzyme. All agents (CJ, JA and MJ) inhibited proliferation of the cells in dose- and kinetic-dependent manners. All the assays confirmed that the inhibition was through the induction of apoptosis and that the mechanism of inhibition may …
-
Elastase inhibitory, anti-inflammatory, and antioxidant potential of South African plants in a multi-faceted anti-ageing approach
… due to the action of cyclooxygenase – II and 5-lipoxygenase result in the release of proteases such as elastase which hydrolyze the structural components if the dermis undesirably. This results in the formation of wrinkles. In the present study eleven terrestrial and wetland plants (Aloe ferox, …
-
Computational Approaches For Designing Protein/inhibitor Complexes And Membrane Protein Variants
… and inhibitors of cyclooxygenase(COX)-I and 5-lipoxygenase (5-LOX). In Part II (Chapters III and IV), I focus on membrane proteins, which are notoriously difficult to work with due to their low natural abundances, low yields for heterologous over expression, and propensities toward aggregation. …
-
The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… are produced from arachidonic acid via 5- lipoxygenase metabolism, resulting in LTB4 and cysteinyl LTs (cysLTs; LTC4, LTD4 and LTE4). CysLTs, which are pro-inflammatory lipid mediators, play a role in asthma and interact with three G-protein-coupled receptors (CysLTR1, CysLTR2, and GPR99). …
-
The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… acid. Leukotrienes (LTs) are generated from 5- lipoxygenase-metabolism of arachidonic acid to LTB4 and cysteinyl LTs (cysLTs). CysLTs are pro-inflammatory lipids that have pathobiological functions in asthma. CysLTs function through three G-protein coupled receptors (CysLTR1, CysLTR2 and GPR99). …
-
Feeding Female Growing Rats Different Sources of Omega-3 Polyunsaturated Fatty Acids Affects Lung Fatty Acid Composition and Gene Expression
… The enzymes involved in eicosanoid synthesis, 5-lipoxygenase (5-LOX) and cyclooxygenase II (COX II), and the antioxidant enzymes, catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase 1 (SOD1), were determined using real-time polymerase chain reaction.;Results: Rats fed FO, …
-
Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus secretion and airway hyperresponsiveness through G-protein coupled receptor, …