Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"5-Hydroxymethylcytosine (5-hmC)"”.
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… of oncogenes have been shown to initiate HCC. 5-hydroxymethylcytosine (5-hmC), recently identified sixth base of the genome, can cause demethylation by its conversion to cytosine through reactions catalyzed by the TET enzymes. Research on the role of this novel modification in the liver and HCC …
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… in the DNA demethylation pathway, 5- hydroxymethylcytosine (5-hmC) is an epigenetic marker that significantly influences gene expression, with major consequences for embryonic development, stem cell identity, and ultimately organ homeostasis. Keratinocyte stem cells (KSC) maintain a …
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The HLA Complex Group 9 Gene Modification Study in Major Psychosis
… distribution of 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in neural and non-neural tissue from mice and humans. 5-hmC has been recently found to be abundant in brain but its function is poorly understood. We assayed 5-hmC by using glucosylation coupled with restriction enzyme …
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Regulation of nucleosome dynamics
In eukaryotic cells, the genome is packed into fundamental units called nucleosomes, where 147 base pairs of DNA are wrapped around a protein core. Stable packing of DNA in nucleosomes imposes a barrier for accessibility of genetic code on DNA for replication, transcription, and repair. The …