Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"5-HT4 receptor"”.
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ …
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Cell Type Specific Roles of Serotonin Receptor 4 in the Hippocampus and Neocortex in Emotion and Cognition
… studies indicate a critical role for Serotonin Receptor 4 (5-HT<sub>4</sub>R, product of the Htr4 gene) in this direction as drugs that activate this receptor show fast-acting antidepressant-like properties. Unfortunately, 5-HT<sub>4</sub>R is widely expressed in the periphery, limiting its use …
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Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain
… nociceptors via the 5-HT<sub>4</sub> receptor and downstream cAMP signaling via PKA and EPAC. Furthermore, whole-cell patch clamp recordings of primary DRG neurons, analysis of spontaneous pain behavior, and RNA sequencing were used to reveal an unexpected persistence of …