Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"5-HT3"”.
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5-HT3 Receptor Ligands and Their Effect on Psychomotor Stimulants
… produced by increasing dopamine levels. 5-HT3 serotonin receptors have been shown to indirectly affect dopamine levels. Therefore, the effect of the 5-HT3 receptor partial agonist, MD-354, on the actions of psychomotor stimulants was analyzed in mouse locomotor activity assays to determine …
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Die Kinetik des heteromeren 5-HT3-Rezeptors: Untersuchungen mit Patch-Clamp-Technik und Computersimulationen
Der 5-HT3-Rezeptor gewinnt zunehmend pharmakologische Bedeutung, z.B. hinsichtlich der Wirkmechanismen von Antidepressiva. Diese wirken u.a. als 5-HT3-Rezeptor-Antagonisten oder hemmen die präsynaptische Serotonin-Wiederaufnahme. Darüber hinaus werden 5-HT3-Antagonisten in der Therapie des …
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Dual Mechanism Analgesia-Enhancing Agents
… effects. Recent studies have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- …
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Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
… bodies.|Agonists selective for 5-HT6/7, 5-HT3, 5-HTia, 5-HTib/id, 5-HT2 and non- selective agonists all caused concentration-related enhancement in evoked [3H]-5-HT release from bovine tissues with the following rank order of potency (as measured by equipotent concentration ratio): 5-CT > …
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The heteromeric 5-HT3A/B receptor:the effect of 5-HT3B subunits on receptor structure and ligand recognition
The 5-HT3 receptors are members of the cys-loop family of ligand-gated ion channels. Two functional subtypes are known, the homomeric 5HT3A and the heteromeric 5HT3A/B receptors, which exhibit distinct biophysical characteristics but are difficult to differentiate pharmacologically. Atomic force …
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Molecular pharmacology of an insect GABA receptor
… their potent insecticidal properties. The 5-HT3 receptor is a member of the Cys-loop receptor family and shows homology to RDL receptors. To explore different techniques for studying Cys-loop receptor function I assessed the functionality of two brain derived transcripts of the 5-HT3B subunit …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… taste buds express only the 5-HT1A and 5-HT3 subtypes. The 5-HT1A subtype was found to be expressed in TRCs, while the 5-HT3 subtype is presumed to be expressed in postsynaptic neural elements. Further, 5-HT and the 5-HT1A receptor have been shown to localize in non-overlapping …
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Studies into Amphetamine-Induced Unconditioned Behaviour in the Rat.
… and sulpiride) and a putative antipsychotic (a 5-HT3 antagonist, ondansetron) on open-field locomotor routes taken by rats following treatment with 3.5mg/kg amphetamine. Measures of stereotyped locomotion derived from image analysis were supported by a novel form of behavioural analysis based on …
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Prophylactic Ondansetron Administration to Attentuate Spinal Anesthesia-Induced Hypotension in Cesarean Section
… shown that 5-hydroxytryptamine subtype 3 (5- HT3) receptor antagonists can effectively reduce BJR activation. Ondansetron is a 5-HT3 receptor antagonist linked to a reduction in the frequency and severity of SAIH. Methods: A presentation of an educational session to improve anesthesia …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
… (5-HT2 receptor antagonist), granisetron (5-HT3 receptor antagonist) and RS 23597 (5-HT4 receptor antagonist) at 1¿M or a combination of ritanserin, granisetron, plus RS 23597 at 1¿M significantly reduced or abolished contractile responses induced by 5-HT. SB 269970A (5-HT7 receptor …
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Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
5-HT3B ist eine Untereinheit des Serotoninrezeptors Typ 3 (5-HT3), einem Ionenkanal aus der Cys-loop-Rezeptorfamilie. Das Gen HTR3B kodiert für 5-HT3B. Der -100_-102delAAG-Polymorphismus im HTR3B-Promotor kann die HTR3B-Promotoraktivität beeinflussen und wurde mit Häufigkeit und Schweregrad von …
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Neuronal plasticity in the enteric nervous system motor pathways
… at muscarinic receptors, 5-HT or ATP acting at 5-HT3 or P2X receptors (respectively), but may have depended upon an increased excitability of enteric neurons. Thus, neuronal plasticity of the enteric nervous system is highly adaptable and able to compensate for inhibition of multiple receptors in …
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Mechanisms of pain processing: spinal protein translation in the rat
… activating or blocking serotonergic spinal 5-HT3 receptors. These pathways have already been proven to be pivotal in the maintenance of persistent pain-like states. The results suggest that mTOR has a continuous role in maintaining persistent pain-like states via rapid local protein …
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Characterization of 5-Hydroxytryptamine-Evoked Isometric Contractile Responses in Aortic Vascular Smooth Muscle in Thyropathological Rats
… TRX group, in light of the apparent lack of 5-HT3 sites in this tissue, may be mediated, in part, by a novel serotonergic receptor mediating contraction. Alternatively, this effect may reflect activity of the ligand at 5-HT1 or 5-HT2 receptors differentially sensitized by thyropathology. These …
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Influencia de campos electromagnéticos en las propiedades cinéticas de canales iónicos activados por neurotransmisores
… excitatorios nicotínico (AChR), de serotonina 5-HT3 y receptores inhibitorios GABAA y de glicina. Desde hace un tiempo, se ha discutido la posibilidad de que los campos magnéticos estáticos (CME) o electromagnéticos (CEM) resulten dañinos para la salud. Debido a los rápidos avances en las …
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Progettazione, sintesi e valutazione farmacologica di derivati del 4-nitro-7-piperazin-1-il-2,1,3-benzossadiazolo come nuovi ligandi sigma fluorescenti
… e del clustering del recettore ionotropico 5-HT3, la visualizzazione in tempo reale del trafficking cellulare e dell'internalizzazione del complesso del ligando con i recettori oppioidi ¦Ì e ¦Ä e infine l¡ ̄oligomerizzazione dei recettori della somatostatina regolata dal legame con il …
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The role of serotonin-2C receptors in the rat circadian system.
… SCN. However, 5-HT2C receptor mRNA along with 5-HT3 receptor, 5-HT5A receptor and 5-HT7 receptor mRNA was expressed in the adult rat SCN tissue but not the SCN2.2 cells. These significant differences in serotonin receptor expression limit the usefulness of this cell line for further …
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The Lipid-Facing M4 Helix of α4β2 nACh and 5-HT3A Receptors
… effects of mutations in the M4 helices of the 5-HT3A and α4β2 nACh receptors. I used a membrane potential-sensitive fluorescent dye, two-electrode voltage clamp and manual patch-clamp for functional characterisation of mutant receptors in HEK293 cells and Xenopus oocytes, and radioligand binding …