Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"5-HT2CR"”.
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Part I: Disruption of PTEN-5-HT2CR Coupling: A Potential Treatment for Restoration of 5-HT2CR Function / Part II: Rapid Total Synthesis of Cyclodepsipeptide MA026
PART I Serotonin 2C receptor (5-HT2CR) plays an important role in regulation of physiology, behavior, and dysfunction in 5-HT2CR neurotransmission may underlie some psychiatric disorders (e.g., depression, drug addiction). The association of the 5-HT2CR with protein phosphatase and tensin homologue …
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PTEN-5-HT2CR Complex: An Ideal Target for Developing Treatment to Restore the Functioning of 5-HT2CR; An Attempt to Minimize the Development of Antimicrobial Resistance
PART I ABSTRACT Serotonin 2C receptor (5-HT2CR) plays an important role in the regulation of neurotransmission disorders and maybe an ideal target to develop treatments for drug addiction. The coupling between the 5-HT2CR and protein phosphatase and tensin homologue (PTEN) limited the activity of …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… and relapse in addicts. The 5-HT2C receptor (5-HT2CR) has been shown to modulate the behavioral effects of acute cocaine administration and, in the present study, we investigated the role of this receptor in the expression of cocaine-induced conditioned hyperactivity. We first test the …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine self-administration has not been investigated. The 5-HT2CR is expressed throughout reward neurocircuitry, but exploration of the …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine self-administration has not been investigated. The 5-HT2CR is expressed throughout reward neurocircuitry, but exploration of the …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… at the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) regulates neurobehavioral processes that may underlie chronic health issues such as impulsivity disorders, drug addiction, depression, schizophrenia, and obesity. Therefore, restoration of the diminished signaling capacity through 5-HT2CR …
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The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… in the serotonin (5 HT)2C receptor (5-HT2CR) system, which exerts an inhibitory influence over the limbic-corticostriatal circuitry and has been implicated in modulating cocaine-evoked behaviors, may play a key role in the development and maintenance of behavioral sensitization. …
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The synthesis of 5-HT2 receptor designed multiple ligands to investigate the role of the 5-HT2AR and the 5-HT2CR in cocaine addiction
Previous studies indicate that the 5-HT2AR and 5-HT2CR play a role in cocaine induced behavior modification through either stimulation or inhibition respectively. Recent research has revealed that dimerization and oligomerization of GPCRs including the 5-HTRs frequently occurs. In order to target …
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Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
… discovery for the serotonin 5-HT2C receptor (5-HT2CR). From the time of its characterization, the 5-HT2CR has been marked by unique, untapped potential as a drug discovery target for numerous diseases and disorders of the central nervous system. Thus, the second chapter in this work provides a …
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Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery
… the serotonin (5-HT) 5-HT2 receptor (i.e., 5-HT2CR and 5-HT2AR) system which may be promising targets for the treatment of neuropsychiatric disorders. The 5-HT2CR has been implicated in anxiety, binge eating disorder, depression, impulsivity, movement disorders, obesity, schizophrenia and …
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Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… neurotransmission through the 5-HT2C receptor (5-HT2CR) and 5-HT2A receptor (5-HT2AR) within the central nervous system is a critical driver of the cognitive and/or behavioral dimensions underlying impulsivity and cue reactivity. Characterization of how these receptors are regulated or altered by …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
… antagonist/inverse agonist pimavanserin and 5-HT2CR agonist lorcaserin used alone or in combination demonstrate efficacy in suppressing measures of binge eating. Pharmacological studies further show that activation of the 5-HT2CR may suppress binge eating by decreasing the reinforcing and …
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Studies in GPCR and Chromosomal Control
… two serotonin receptors, 5-HT2AR and 5-HT2CR, to have a synergistic effect on cocaine-related impulsivity. Not only do they function as individual receptors in the process, but they also form functional hetero-dimers in which 5-HT2AR signaling is blunted. The goal of this research is to …
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A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
… that the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) agonist lorcaserin robustly diminishes the reinforcing value of the prescription opioid oxycodone (OxyContin®) and does not possess abuse liability. We also have identified a list of genes associated with high drug relapse vulnerability that …