Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"5-HT2C receptor"”.
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Role of 5-ht2c receptor density on behaviour in mice
… and in the regulation of locomotion. The 5-HT2C receptor is one of fourteen 5-HT receptor subtypes that is expressed in regions of the brain including the hippocampus, amygdala, dorsal striatum, nucleus accumbens (NA) and substantia nigra, and is therefore implicated in behaviours and …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… effects of cocaine particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine self-administration has not been investigated. The 5-HT2CR is expressed throughout reward neurocircuitry, but exploration …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… effects of cocaine particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine self-administration has not been investigated. The 5-HT2CR is expressed throughout reward neurocircuitry, but exploration …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… signaling capacity at the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) regulates neurobehavioral processes that may underlie chronic health issues such as impulsivity disorders, drug addiction, depression, schizophrenia, and obesity. Therefore, restoration of the diminished signaling capacity …
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The role of serotonin-2C receptors in the rat circadian system.
… of light information with activation of 5-HT2C receptors at night having a photo-mimetic effect. The studies described in this thesis aim to clarify the role of 5-HT2C receptors in the control of circadian rhythms in the rat model and compare their actions to light. The acute effects of …
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Serotonin receptor mechanisms in anti-depressant action
… suggesting the existence of multiple serotonin receptor subtypes and the genes for these receptors, as well as that of the serotonin transporter, have common polymorphic variants. To investigate the effect of repeated treatment with selective serotonin fe-uptake inhibitors (SSRI's) on the …
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The design, synthesis, and biological evaluation of aplysinopsin analogs as potential neuromodulators
… analogs revealed that of the 12 serotonin receptor subtypes and 34 other CNS receptors, aplysinopsin analogs shoa high affinity for the 5-HT2B and 5-HT2C receptor subtypes, with selectivity for 5-HT2B over 5-HT2C. Bromination at C-4 and C-5 of the indole ring resulted in greater binding …
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Age- and sex-specific effects of amphetamines on cognition and serotonin in the orbitofrontal cortex
… to amphetamines on cognitive flexibility and 5-HT2C receptor structure and function (Experiments 1, 3, 4) and (2) by examining age and sex differences in intravenous methamphetamine self-administration (Experiment 2). In Experiment 1, male and female Sprague-Dawley rats were treated with …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… paired with noradrenaline transporter, H3 receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT2C receptor, Melanocortin 4 receptor and Neurokinin 1 receptor respectively). COMBI-SVMs were compared to other VS methods in varies testing sets (e.g. MDDR and PubChem databases). They showed …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… to drug craving and relapse in addicts. The 5-HT2C receptor (5-HT2CR) has been shown to modulate the behavioral effects of acute cocaine administration and, in the present study, we investigated the role of this receptor in the expression of cocaine-induced conditioned hyperactivity. We first …
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A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
… findings demonstrate that the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) agonist lorcaserin robustly diminishes the reinforcing value of the prescription opioid oxycodone (OxyContin®) and does not possess abuse liability. We also have identified a list of genes associated with high drug relapse …
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Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
The discovery of G protein-coupled receptors (GPCRs) and the extensive second messenger systems associated with their activation has ushered in an enormously productive period in drug discovery. The extent to which around one-third of FDA-approved medications target GPCRs. Predictably, small …
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Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… Serotonin (5-HT) neurotransmission through the 5-HT2C receptor (5-HT2CR) and 5-HT2A receptor (5-HT2AR) within the central nervous system is a critical driver of the cognitive and/or behavioral dimensions underlying impulsivity and cue reactivity. Characterization of how these receptors are …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
… the clinically-approved serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist/inverse agonist pimavanserin and 5-HT2CR agonist lorcaserin used alone or in combination demonstrate efficacy in suppressing measures of binge eating. Pharmacological studies further show that activation of the 5-HT2CR …