Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"5-HT2C"”.
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Role of 5-ht2c receptor density on behaviour in mice
… and in the regulation of locomotion. The 5-HT2C receptor is one of fourteen 5-HT receptor subtypes that is expressed in regions of the brain including the hippocampus, amygdala, dorsal striatum, nucleus accumbens (NA) and substantia nigra, and is therefore implicated in behaviours and …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… effects of cocaine particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine self-administration has not been investigated. The 5-HT2CR is expressed throughout reward neurocircuitry, but exploration …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… effects of cocaine particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine self-administration has not been investigated. The 5-HT2CR is expressed throughout reward neurocircuitry, but exploration …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… signaling capacity at the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) regulates neurobehavioral processes that may underlie chronic health issues such as impulsivity disorders, drug addiction, depression, schizophrenia, and obesity. Therefore, restoration of the diminished signaling capacity …
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The role of serotonin-2C receptors in the rat circadian system.
… of light information with activation of 5-HT2C receptors at night having a photo-mimetic effect. The studies described in this thesis aim to clarify the role of 5-HT2C receptors in the control of circadian rhythms in the rat model and compare their actions to light. The acute effects of …
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Serotonin receptor mechanisms in anti-depressant action
… inhibitors (SSRI's) on the function of central 5-HT2C receptors. To assess the effect of polymorphic variation in the 5-HT2c receptor and serotonin transporter on functional responses to selective pharmacological challenge. To determine whether polymorphic variation in the 5-HT receptor and …
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The design, synthesis, and biological evaluation of aplysinopsin analogs as potential neuromodulators
… analogs shoa high affinity for the 5-HT2B and 5-HT2C receptor subtypes, with selectivity for 5-HT2B over 5-HT2C. Bromination at C-4 and C-5 of the indole ring resulted in greater binding affinities, with Ki's as low as 35 nM. In addition, biological evaluation of the MAO-A and MAO-B inhibitory …
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Age- and sex-specific effects of amphetamines on cognition and serotonin in the orbitofrontal cortex
… to amphetamines on cognitive flexibility and 5-HT2C receptor structure and function (Experiments 1, 3, 4) and (2) by examining age and sex differences in intravenous methamphetamine self-administration (Experiment 2). In Experiment 1, male and female Sprague-Dawley rats were treated with …
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Regulation of biochemical pathways involved in neurodegeneration
… AP formation. Activation of 5-HT2A or 5-HT2c receptors has been shown to increase APPS secretion in vitro; therefore, we determined whether activation of these receptors might have a similar effect in vivo. We found that a 5-HT2A/2c agonist affected brain APP metabolism in guinea pigs by …
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Cocaine Dependence: The Role of Serotonin Genes In
… on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the disruption of cocaine-associated memories. One measure of cocaine related cues in humans is attentional bias, in which cocaine dependent …
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Inibição neonatal da recaptação da serotonina: estudo de eventuais alterações na expressão gênica de receptores serotoninérgicos, no comportamento alimentar e em indicadores metabólicos
… expressão gênica hipotalâmica de 5-HT1B, 5-HT2C, NPY e POMC, tolerância à glicose; níveis plasmáticos de triglicerídeos e colesterol antes após ingestão crônica de dieta hipercalórica. Os animais tratados com SSRI no período neonatal apresentaram, na idade adulta, menores peso corporal e …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… H3 receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT2C receptor, Melanocortin 4 receptor and Neurokinin 1 receptor respectively). COMBI-SVMs were compared to other VS methods in varies testing sets (e.g. MDDR and PubChem databases). They showed comparable dual-inhibitor yields, moderate to good …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… to drug craving and relapse in addicts. The 5-HT2C receptor (5-HT2CR) has been shown to modulate the behavioral effects of acute cocaine administration and, in the present study, we investigated the role of this receptor in the expression of cocaine-induced conditioned hyperactivity. We first …
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A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
… findings demonstrate that the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) agonist lorcaserin robustly diminishes the reinforcing value of the prescription opioid oxycodone (OxyContin®) and does not possess abuse liability. We also have identified a list of genes associated with high drug relapse …
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Small Molecule Allosteric Modulation of G Protein-Coupled Receptors and Applications in the Pharmacological Targeting of 5-HT2 Receptors
… modulator discovery for the serotonin 5-HT2C receptor (5-HT2CR). From the time of its characterization, the 5-HT2CR has been marked by unique, untapped potential as a drug discovery target for numerous diseases and disorders of the central nervous system. Thus, the second chapter in this …
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Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… Serotonin (5-HT) neurotransmission through the 5-HT2C receptor (5-HT2CR) and 5-HT2A receptor (5-HT2AR) within the central nervous system is a critical driver of the cognitive and/or behavioral dimensions underlying impulsivity and cue reactivity. Characterization of how these receptors are …
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Aspects of tic like behaviour and serotonergic control
… fore-paw-tremor and -licking. The 5-HT2C/2B antagonist SB200646A was without effect on blinking and fore-paw-licking but dose-dependently potentiated fore-paw-tremor. The 5-HT1A agonists 8-OH DPAT and buspirone attenuated blinking at the lower doses tested but were ineffective at the …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… and serotonin receptors (5-HT1A, 5-HT1B, and 5-HT2C) within the CeA. Electrophysiological findings revealed distinct sex-dependent and subregion-specific mechanisms of modulation. In males, both naïve and dependent, acute alcohol increased GABAergic transmission in the medial CeA (CeM) and …
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METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
… . We selected two SNPs: rs6318 for the 5-HT2C gene and rs6275 for the DRD2 gene, identified in our population study as related to BMI changes after SGAs administration and already evaluated in correlation with weight gain, metabolic ADRs, and antipsychotic treatment with a focus on SNC …
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Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.
… a 5-HT1A partial agonist (buspirone), a 5-HT2C antagonist (SB-243213A) and an agonist and positive allosteric modulator of the alpha 7 nACh receptor (PNU-282987 and PheTQS respectively) are able to reverse the sub-chronic PCP-induced deficit in reversal learning. Although many …
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