Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"5-HT2AR"”.
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The synthesis of 5-HT2 receptor designed multiple ligands to investigate the role of the 5-HT2AR and the 5-HT2CR in cocaine addiction
Previous studies indicate that the 5-HT2AR and 5-HT2CR play a role in cocaine induced behavior modification through either stimulation or inhibition respectively. Recent research has revealed that dimerization and oligomerization of GPCRs including the 5-HTRs frequently occurs. In order to target …
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Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
The 5-HT2A receptor (5-HT2AR) is implicated in neuropsychiatric disorders such as schizophrenia and is thought to mediate the actions of a number of hallucinogenic and antipsychotic drugs. Additionally, certain polymorphic variants of the receptor, such as an allele resulting in substitution of …
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The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… at the G protein-coupled 5-HT2A receptor (5-HT2AR) regulate impulsive action and the attentional orienting to drug cues (cue reactivity) based upon extensive pharmacological studies with investigational 5-HT2AR antagonists/inverse agonists. We first established the potential for repurposing …
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INDIVIDUAL DIFFERENCES IN IMPULSIVE ACTION AND TEMPORAL ESTIMATION: INTERACTION WITH THE SEROTONIN (5-HT) 5-HT2A RECEPTOR
… action. Manipulation of the 5-HT2A receptor (5-HT2AR) influences impulsive action and timing functions, suggesting that functional capacity of the 5-HT2AR system may drive the predisposition to inherent impulsive action. Few studies have defined the neurobiological determinants of individual …
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Impact of genetic variability in the serotonin transporter, Tryptophan Hydroxylase-2, and Serotonin 2A Receptors on MDMA Use and Impulsivity
… 5-HT transporter (5-HTT), and 5-HT2A receptor (5-HT2AR) in the effects of MDMA is incompletely understood. Our initial study compared the prevalence of polymorphisms leading to reduced gene expression in those genes among MDMA users versus controls, and assessed the relationship between these …
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Protein-Protein Interactions with Serotonin G Protein Coupled Receptors: Novel Targets for Neurotherapeutics Drug Discovery
… (5-HT) 5-HT2 receptor (i.e., 5-HT2CR and 5-HT2AR) system which may be promising targets for the treatment of neuropsychiatric disorders. The 5-HT2CR has been implicated in anxiety, binge eating disorder, depression, impulsivity, movement disorders, obesity, schizophrenia and substance use …
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Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
… serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist/inverse agonist pimavanserin and 5-HT2CR agonist lorcaserin used alone or in combination demonstrate efficacy in suppressing measures of binge eating. Pharmacological studies further show that activation of the 5-HT2CR may suppress …
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Individual sensitivity to novelty and (+)-3,4-methylenedioxymethamphetamine: Roles for serotonin and GABA neurotransmission
… in particular the 5-HT2A receptor (5-HT2AR) in the nucleus accumbens (NAc) and prefrontal cortex (PFC). We then carried this finding into a model of individual difference in which animals are separated based on their differential locomotor response to a novel environment into high …
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Studies in GPCR and Chromosomal Control
… has identified two serotonin receptors, 5-HT2AR and 5-HT2CR, to have a synergistic effect on cocaine-related impulsivity. Not only do they function as individual receptors in the process, but they also form functional hetero-dimers in which 5-HT2AR signaling is blunted. The goal of this …
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Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
… of binding partners in the regulation of 5-HT2AR.
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Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… 5-HT2C receptor (5-HT2CR) and 5-HT2A receptor (5-HT2AR) within the central nervous system is a critical driver of the cognitive and/or behavioral dimensions underlying impulsivity and cue reactivity. Characterization of how these receptors are regulated or altered by genetic and epigenetic means …
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Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors
… and 5-HT7AR and lacked affinity at 5-HT1BR and 5-HT2AR. This series contained compounds with an N6-methyl group and compounds with and N6-propyl group. The N6-methyl substituted C10 nitrogen functionalized aporphine analogs had higher binding affinities at 5-HT7AR versus 5-HT1AR. In contrast the …
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Expression and function of serotonin receptor isoforms in the respiratory system
… C aktivieren. Selektive Aktivierung des 5-HT2AR mittels a-methyl-5-HT bewirkte lediglich eine transiente respiratorische Depression und eine persistierende Hypotonie. Di e Injektion des 5-HT2BR-Agonisten (BW 723C86) und Antagonisten (LY 272015) zeigte keine Effekte. Obwohl alle untersuchten …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… shown ex vivo and is correlated with KCC2 or 5-HT2AR agonist-mediated reduction in diazepam or alcohol consumption, respectively. In all three chapters, correction of the aberrant inhibitory signaling reversed the corresponding behavior back to its control level. Collectively, this work suggests …