Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"5-HT2A receptor"”.
-
Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… was to characterize the mechanisms by which 5-HT2A receptor signaling and calmodulin (CaM) regulate TGase-catalyzed transamidation of Rac1 and htt in cultured neuronal cells and HD transgenic animals, respectively.</p><p>5-HT2A receptors are G-protein coupled receptors which are widely …
-
Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
The 5-HT2A receptor (5-HT2AR) is implicated in neuropsychiatric disorders such as schizophrenia and is thought to mediate the actions of a number of hallucinogenic and antipsychotic drugs. Additionally, certain polymorphic variants of the receptor, such as an allele resulting in substitution of …
-
INDIVIDUAL DIFFERENCES IN IMPULSIVE ACTION AND TEMPORAL ESTIMATION: INTERACTION WITH THE SEROTONIN (5-HT) 5-HT2A RECEPTOR
… regulate impulsive action. Manipulation of the 5-HT2A receptor (5-HT2AR) influences impulsive action and timing functions, suggesting that functional capacity of the 5-HT2AR system may drive the predisposition to inherent impulsive action. Few studies have defined the neurobiological determinants …
-
Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
… expression of the mRNA for the serotonin 5-HT2A receptor, a known modulator of the behavioral effects of MDMA, and its binding partners, were observed at 24 hrs withdrawal. However, these results were not validated by quantitative RT-PCR nor did Western blot analyses reveal a disruption in …
-
The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… and 5-HT actions at the G protein-coupled 5-HT2A receptor (5-HT2AR) regulate impulsive action and the attentional orienting to drug cues (cue reactivity) based upon extensive pharmacological studies with investigational 5-HT2AR antagonists/inverse agonists. We first established the potential …
-
Developmental Monoamine Signaling Impacts Adult Affective and Aggressive Behaviors
… blockade. Chapter IV focuses on the role of 5-HT2A receptor signaling in mediating the effect of P2-11 5-HTT blockade on adult behavior. Htr2a-/- mice display reduced conflict anxiety. Because 5-HT2A receptor antagonists do not reduce conflict anxiety in adulthood, I hypothesized that the …
-
Investigation into the biochemical changes in Tourette Syndrome with a potential for pharmacological manipulation
… and another study showed that KYN potentiated 5-HT2A-mediated head-shakes (HS) in rodents. These movements have been suggested to model tics in TS. This raised the questions how KYN acts in eliciting this response and whether it is an action of its own or of a further metabolite along the …
-
Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders
… the clinically-approved serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist/inverse agonist pimavanserin and 5-HT2CR agonist lorcaserin used alone or in combination demonstrate efficacy in suppressing measures of binge eating. Pharmacological studies further show that activation of the …
-
Studies Toward the Synthesis of Salvinorin A and Synthesis of Broad-Spectrum DENV/WNV NS3 Protease Inhibitors
… and the first that is not an agonist of the 5-HT2A receptor. It is a potent, selective agonist of the Kappa opioid receptor (KOR). The aim of our current research is to complete the total synthesis of Salvinorin A, then to synthesize novel analogs not attainable by semi-synthetic methods. The …
-
Individual sensitivity to novelty and (+)-3,4-methylenedioxymethamphetamine: Roles for serotonin and GABA neurotransmission
… (5-HT) neurotransmission, in particular the 5-HT2A receptor (5-HT2AR) in the nucleus accumbens (NAc) and prefrontal cortex (PFC). We then carried this finding into a model of individual difference in which animals are separated based on their differential locomotor response to a novel …
-
Impact of genetic variability in the serotonin transporter, Tryptophan Hydroxylase-2, and Serotonin 2A Receptors on MDMA Use and Impulsivity
… (TPH-2), 5-HT transporter (5-HTT), and 5-HT2A receptor (5-HT2AR) in the effects of MDMA is incompletely understood. Our initial study compared the prevalence of polymorphisms leading to reduced gene expression in those genes among MDMA users versus controls, and assessed the relationship …
-
Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… (5-HT) neurotransmission through the 5-HT2C receptor (5-HT2CR) and 5-HT2A receptor (5-HT2AR) within the central nervous system is a critical driver of the cognitive and/or behavioral dimensions underlying impulsivity and cue reactivity. Characterization of how these receptors are regulated or …
-
Glutamate and MDMA Neurobehavioral Toxicity
… Furthermore, serotonergic signaling through the 5HT2A/C receptor was implicated in the underlying mechanism of glutamate release by the attenuation of the MDMA effect with either the SSRI fluoxetine or the 5-HT2A/C inhibitor ketanserin. Local administration of the sodium-channel blocker TTX did …
-
The role of serotonin-2C receptors in the rat circadian system.
… of light information with activation of 5-HT2C receptors at night having a photo-mimetic effect. The studies described in this thesis aim to clarify the role of 5-HT2C receptors in the control of circadian rhythms in the rat model and compare their actions to light. The acute effects of 5-HT2C …
-
Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
… weak partial agonist activity at the serotonin 5-HT2A receptor subtype, while another study reported that EFV induces depression and anxiogenic behaviour. More recently, the addictive properties of EFV has been established in a preclinical study, which reported that sub-acute and sub-chronic …