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Showing 1 to 20 of 33 for “"5-HT2A"”.

  1. Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin

    Dai, Ying2016

    … was to characterize the mechanisms by which 5-HT2A receptor signaling and calmodulin (CaM) regulate TGase-catalyzed transamidation of Rac1 and htt in cultured neuronal cells and HD transgenic animals, respectively.</p><p>5-HT2A receptors are G-protein coupled receptors which are widely …

    loyola-thes Repository record

  2. Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant

    Barclay, Zoë JadeThe University of Edinburgh2010

    The 5-HT2A receptor (5-HT2AR) is implicated in neuropsychiatric disorders such as schizophrenia and is thought to mediate the actions of a number of hallucinogenic and antipsychotic drugs. Additionally, certain polymorphic variants of the receptor, such as an allele resulting in substitution of …

    edinburgh Repository record

  3. INDIVIDUAL DIFFERENCES IN IMPULSIVE ACTION AND TEMPORAL ESTIMATION: INTERACTION WITH THE SEROTONIN (5-HT) 5-HT2A RECEPTOR

    Fink, Latham Henry LeedsThe University of Texas Medical Branch at Galveston2021

    … regulate impulsive action. Manipulation of the 5-HT2A receptor (5-HT2AR) influences impulsive action and timing functions, suggesting that functional capacity of the 5-HT2AR system may drive the predisposition to inherent impulsive action. Few studies have defined the neurobiological determinants …

    utmb Repository record

  4. Exploring the effects of 5-HT2A and AMPA receptors on brain 5-HT via a mechanism-based pharmacodynamic model

    Zhou, Zhu2018

    Depression is a common mood disorder. Although major ethical challenges make it nearly impossible to invasively and directly measure serotonin (5-hydroxytryptamine, 5-HT) levels in human brains, neuroimaging technologies have shown macroscopic structural and functional abnormalities in the …

    u-pacific Repository record

  5. Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners

    Margaret Roserika BrooksThe University of Texas Medical Branch2005

    … expression of the mRNA for the serotonin 5-HT2A receptor, a known modulator of the behavioral effects of MDMA, and its binding partners, were observed at 24 hrs withdrawal. However, these results were not validated by quantitative RT-PCR nor did Western blot analyses reveal a disruption in …

    utmb Repository record

  6. The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence

    Sholler, Dennis JThe University of Texas Medical Branch at Galveston2019

    … and 5-HT actions at the G protein-coupled 5-HT2A receptor (5-HT2AR) regulate impulsive action and the attentional orienting to drug cues (cue reactivity) based upon extensive pharmacological studies with investigational 5-HT2AR antagonists/inverse agonists. We first established the potential …

    utmb Repository record

  7. Caractérisation du mécanisme d'action du récepteur sérotoninergique de type 5-HT2A dans les cellules de choriocarcinomes placentaires humains BeWo et JEG-3

    Arseneault, MadeleineUniversité de Moncton2006

    … récepteurs sérotoninergiques dont le récepteur 5-HT2A. Ce dernier fait partie de la grande famille des récepteurs couplés aux protéines G (RCPG). Un effet stimulateur de la 5-HT sur la croissance cellulaire a été décrit au niveau de plusieurs types cellulaires dont les tissus fœtaux et différents …

    moncton Repository record

  8. The synthesis of 5-HT2 receptor designed multiple ligands to investigate the role of the 5-HT2AR and the 5-HT2CR in cocaine addiction

    Shashack, Matthew 1981-The University of Texas Medical Branch at Galveston2016

    Previous studies indicate that the 5-HT2AR and 5-HT2CR play a role in cocaine induced behavior modification through either stimulation or inhibition respectively. Recent research has revealed that dimerization and oligomerization of GPCRs including the 5-HTRs frequently occurs. In order to target …

    utmb Repository record

  9. Investigation into the biochemical changes in Tourette Syndrome with a potential for pharmacological manipulation

    Kariyawasam, Sandya H.Aston University1999

    … and another study showed that KYN potentiated 5-HT2A-mediated head-shakes (HS) in rodents. These movements have been suggested to model tics in TS. This raised the questions how KYN acts in eliciting this response and whether it is an action of its own or of a further metabolite along the …

    aston Repository record

  10. Aspects of tic like behaviour and serotonergic control

    McCreary, Andrew C.Aston University1995

    … effect on these behaviours. Ketanserin (5-HT2A/ alpha-1 antagonist) and ritanserin (5-HT2A/2C antagonist) were able to attenuate MK771-induced blinking and ketanserin, mianserin (5-HT2A/2C antagonist) and prazosin (alpha-1 adrenoceptor antagonist) were able to attenuate MK771-induced …

    aston Repository record

  11. Predicción de actividad inhibitoria de moléculas pequeñas sobre el receptor serotoninérgico 5 HT2 A mediante modelos de machine learning

    Rojas Mena, Aramis AdrianaUniversitat Oberta de Catalunya (UOC)2020

    … pequeñas sobre el receptor serotoninérgico 5-HT2A. Este receptor se asocia a patologías psiquiátricas ya conocidas, para las cuales existe tratamiento con moléculas pequeñas que lo inhiben, pero con frecuentes efectos adversos. Se prueban algoritmos tanto de clasificación como de regresión, …

    catalunya Repository record

  12. The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy

    Jung, Seung Ho

    … 5-HT receptor subtypes (5-HT1A, 5-HT1B and/or 5-HT2A) were analyzed in the brainstem and cerebellum. In Specific Aim 1, mice were individually housed in a cage equipped with a running wheel for a period of seven acclimation days, three baseline days, and seven post days after 3-time …

    south-carolina Repository record

  13. Regulation of biochemical pathways involved in neurodegeneration

    Pooler, Amy MelissaMassachusetts Institute of Technology2005

    … thereby preventing AP formation. Activation of 5-HT2A or 5-HT2c receptors has been shown to increase APPS secretion in vitro; therefore, we determined whether activation of these receptors might have a similar effect in vivo. We found that a 5-HT2A/2c agonist affected brain APP metabolism in …

    mit Repository record

  14. Cocaine Dependence: The Role of Serotonin Genes In

    Maili, Lorena2011

    … agents on serotonin receptors 2a (5-HT2A) and 2c (5-HT2C), have yielded results suggesting that selective 5-HT2A antagonists and 5-HT2C agonists promote the disruption of cocaine-associated memories. One measure of cocaine related cues in humans is attentional bias, in which cocaine …

    uthsc Repository record

  15. PET-imaging in depression and antidepressant therapies : focus on the serotonin system and the cerebral glucose metabolism

    Van Laeken, NickGhent University. Faculty of Pharmaceutical Sciences2018

    … transporter to the serotonin 5-HT1A and 5-HT2A receptors to explore the role of the serotonin system in the pathophysiology of this depression model in the rat. For this purpose, three radiotracers were applied: [11C]DASB, [18F]MPPF, and [18F]altanserin. This allowed to image the serotonin …

    ghent Repository record

  16. Glutamate and MDMA Neurobehavioral Toxicity

    Anneken, John H.University of Cincinnati2012

    … Furthermore, serotonergic signaling through the 5HT2A/C receptor was implicated in the underlying mechanism of glutamate release by the attenuation of the MDMA effect with either the SSRI fluoxetine or the 5-HT2A/C inhibitor ketanserin. Local administration of the sodium-channel blocker TTX did …

    ohiolink Repository record

  17. Developmental Monoamine Signaling Impacts Adult Affective and Aggressive Behaviors

    Yu, Qinghui2012

    … blockade. Chapter IV focuses on the role of 5-HT2A receptor signaling in mediating the effect of P2-11 5-HTT blockade on adult behavior. Htr2a-/- mice display reduced conflict anxiety. Because 5-HT2A receptor antagonists do not reduce conflict anxiety in adulthood, I hypothesized that the …

    columbia-diss Repository record

  18. Gene discovery: Polymorphism association with obsessive-compulsive disorder and proteome analysis of Artemisia annua.

    Van Nieuwerburgh, Filip2007

    … (COMT) NlaIII high/low activity polymorphism; 5-HT2A 1438 A/G polymorphism; 5-HT1Dβ G861C polymorphism and the 5-HTTLPR 44-bp deletioninsertion. There was a higher frequency of the DRD2 A2 allele (p = 0.020) and a higher frequency of the low-activity COMT allele (p = 0.035) in male OCD patients …

    ghent Repository record

  19. Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

    Noelle Catherine AnastasioThe University of Texas Medical Branch2005

    … Furthermore, we discovered that D1, D2, and 5-HT2A receptors play a pivotal role in sub-chronic PCP-induced up-regulation of NR1 and NR2A. Finally, we were able to correlate changes in NMDA receptor subunits to the behavioral effects of PCP in this animal model of schizophrenia.

    utmb Repository record

  20. Charakterisierung von Calcium-Transienten in Astrozyten der ventralen respiratorischen Gruppe

    Härtel, Kai2012

    … intrazelluläre Calcium-Freisetzung, die durch 5-HT2a-, Neurokinin-1- und TRH-Rezeptoren vermittelt wird, besteht somit die Möglichkeit, dass Astrozyten auf eine aktivitätsabhängige Ausschüttung dieser für das respiratorische System wichtigen Neuromodulatoren reagieren und so Einfluss auf die …

    goettingen Repository record

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