Global ETD Search
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Showing 1 to 4 of 4 for “"5-HT1AR"”.
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Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors
… series displayed higher affinity at 5-HT1AR and 5-HT7AR and lacked affinity at 5-HT1BR and 5-HT2AR. This series contained compounds with an N6-methyl group and compounds with and N6-propyl group. The N6-methyl substituted C10 nitrogen functionalized aporphine analogs had higher binding …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… application or 3 days). In both conditions the 5-HT1AR Ilight responses resembled those of chronic treatment and differed substantially from controls, suggesting that reduced 5-HT reuptake was likely to be a contributing factor. Collectively, instead of autoreceptor desensitization, our results …
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Expression and function of serotonin receptor isoforms in the respiratory system
… 8-OH-DPAT konnte dabei auf die Aktivierung des 5-HT1AR zurückgeführt werden. Da die 5-HT1A und µ-Opioid Rezeptoren die intrazelluläre cAMP Konzentration senken und der 5-HT7R keine systemische Wirkung zeigte, ist die Wirkung von 8-OH-DPAT auf einen komplexeren Netzwerkeffekt zurückzuführen. Anhand …
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New alkylpiperazines as 5-HT7R ligands
Il recettore 5-HT7 è l’ultimo membro della famiglia dei recettori della serotonina, fu clonato e identificato per la prima volta nel 1993 e appartiene alla superfamiglia dei recettori accoppiati a proteina G. Lo splicing alternativo del gene che codifica per il recettore 5-HT7 genera isoforme …