Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"5-HT1A receptors"”.
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THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
Serotonin 1A receptors (5-HT1A Rs) are implicated in the control of mood, cognition and memory. Dysfunction of 5-HT1A R signaling results in various neuropsychiatric disorders such as depression, anxiety and schizophrenia. Thus, 5-HT1A Rs are a good target for the treatment of the neuropsychiatric …
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Hindbrain Serotonin Neurons Activate 5-HT1A Receptors in the Nucleus Tractus Solitarius (NTS) to Modulate Sympathetic and Ventilatory Recovery Following Hypotensive Hemorrhage
… are needed.</p><p>Our lab has found that 5-HT1A-receptor agonist, 8-OH-DPAT, increases perfusion pressure and improves acid-base balance in hypovolemic rats by stimulation of sympathetic-mediated increases in venous tone. These data suggest that 8-OH-DPAT may be a promising adjuvant agent in …
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Activation of 5-HT1A Receptors in the Nucleus Tractus Solitarius Facilitate Ventilatory Responses to Hypoxic Hypercapnia and Promote Sympathetic Recovery Following Hypotensive Hemorrhage
… during hemorrhage to activate 5-HT<sub>1A</sub> receptors which facilitate chemoreflex responses. We utilized viral-mediated knockdown of the rat 5-HT<sub>1A</sub> receptor in the caudal NTS (cNTS) to examine the role of 5-HT<sub>1A</sub> receptors on compensation following hemorrhage and …
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New Instrumentation and Methods for Analyzing Biological Compounds for Drug Discovery and Discovering Novel Disease Markers
… to different disease states. G-protein coupled receptors currently compose 50% of drug targets, signifying their importance in the pharmaceutical industry. Therefore, monitoring the binding events of ligands to receptors within the cell membrane is highly important for drug development. One key …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… of existing comparative data on serotonin 1A (5-HT1A) receptor signaling in adult hypothalamic rat paraventricular nucleus (PVN).</p> <p>Given the clinical relevance of potential age-dependent differences in serotonergic signaling and regulation of hypothalamic function, the objective of the …
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PET-imaging in depression and antidepressant therapies : focus on the serotonin system and the cerebral glucose metabolism
… the serotonin transporter to the serotonin 5-HT1A and 5-HT2A receptors to explore the role of the serotonin system in the pathophysiology of this depression model in the rat. For this purpose, three radiotracers were applied: [11C]DASB, [18F]MPPF, and [18F]altanserin. This allowed to image the …
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The neurodevelopmental impact of stress and inflammation during pregnancy: influence of the maternal microbiome and gut health
… likely associated with a reduced expression of 5-HT1a receptors in the prefrontal cortex. Finally, the potential of prenatal Lacticaseibacillus rhamnosus exposure in modifying neurodevelopment processes and behavioural outcomes via modulation of the maternal microbiome in a healthy pregnancy was …