Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"5-HT1A receptor"”.
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5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
… is mediated by somatodendritic 5-HT[1A] autoreceptors. The presence of 5-HT[1A] receptor is thought to be increased in depressed patients, producing a reduction in the synthesis of 5-HT. A common single nucleotide polymorphism in the promoter region of 5HT[1A] receptor C-1019G is also …
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The effects of chronic ethanol self-administration on the serotonin system in monkeys
… via the serotonin transporter (SERT) and 5-HT1A receptor. Illuminating the mechanisms underlying the effects of chronic ethanol on the SERT and the 5-HT1A receptor in the hippocampus may help to identify additional targets for the treatment of alcoholism.
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… our understanding of the mechanisms of 5-HT receptor signaling and the actions of drugs on serotonergic function have been derived from extensive preclinical research carried out using cell lines in vitro or in adult animal models in vivo. Fewer studies have investigated serotonergic …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… Inhibitor (SSRI) is loss of somatodendritic 5-HT1A receptor-mediated autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually purinergic has left the actual role of serotonin in the taste bud enigmatic. Across mammalian species, 5-HT is highly conserved …
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Virtual Screening of Multi-Target Agents by Combinatorial Machine Learning Methods
… paired with noradrenaline transporter, H3 receptor, 5-HT1A receptor, 5-HT1B receptor, 5-HT2C receptor, Melanocortin 4 receptor and Neurokinin 1 receptor respectively). COMBI-SVMs were compared to other VS methods in varies testing sets (e.g. MDDR and PubChem databases). They showed …
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Freud-1, a novel regulator of the dopamine D2 and serotonin 1A receptor genes
… which is implicated in the regulation of the 5-HT1A receptor and is genetically linked to non-syndromic mental retardation. Initially, I have characterized the repressor activity of a novel long isoform of human Freud-1 and shown that it is the major isoform expressed in human cells, and that it …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ …
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Hindbrain Serotonin Neurons Activate 5-HT1A Receptors in the Nucleus Tractus Solitarius (NTS) to Modulate Sympathetic and Ventilatory Recovery Following Hypotensive Hemorrhage
… are needed.</p><p>Our lab has found that 5-HT1A-receptor agonist, 8-OH-DPAT, increases perfusion pressure and improves acid-base balance in hypovolemic rats by stimulation of sympathetic-mediated increases in venous tone. These data suggest that 8-OH-DPAT may be a promising adjuvant agent in …
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Role of 5-ht2c receptor density on behaviour in mice
… and in the regulation of locomotion. The 5-HT2C receptor is one of fourteen 5-HT receptor subtypes that is expressed in regions of the brain including the hippocampus, amygdala, dorsal striatum, nucleus accumbens (NA) and substantia nigra, and is therefore implicated in behaviours and disorders …
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3,4-Diaminopyridin evozierte Freisetzung von Neurotransmittern aus Hirnschnitten von Ratten
… befassten wir uns mit dem Nachweis von 5-HT1A-Rezeptoren im Hippocampus von Ratten, die nach einer Läsion des serotonergen Systems eine intrahippocampale Transplantation serotonerger Neurone erhielten. <br>Dabei ergaben sich folgende Resultate: <br>1. Sowohl bei denen mit [³H]5-HT, wie …
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Dose-Response Effects of Lithium on Spatial Memory in the Black Molly Fish.
… We have immunolocalized a 5-HT<sub>1A</sub>-like receptor from the caudal midbrain of black mollies, an area structurally homologous to the mammalian raphe nuclei. This autoinhibitory receptor is considered to be involved in the regulation of firing of raphe serotonergic fibers and 5-HT release in …
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Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
… spezifisch moduliert. Oligomerisation des 5-HT1A Rezeptors. Die vorliegende Studie analysiert den Oligomerisationszustand des 5-HT1A Rezeptors und untersucht die Oligomerisationsdynamik in lebenden Zellen. Gleichzeitig wurde der Einfluss der Rezeptorpalmitoylierung auf diesen Prozess …