Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"5-HT1A"”.
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THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
Serotonin 1A receptors (5-HT1A Rs) are implicated in the control of mood, cognition and memory. Dysfunction of 5-HT1A R signaling results in various neuropsychiatric disorders such as depression, anxiety and schizophrenia. Thus, 5-HT1A Rs are a good target for the treatment of the neuropsychiatric …
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5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
Serotonin (5-HT) neurotransmission is involved in the psychopharmacology of several psychiatric disorders including, depression, anxiety disorders and schizophrenia. The release of 5-HT in neurons is mediated by somatodendritic 5-HT[1A] autoreceptors. The presence of 5-HT[1A] receptor is thought to …
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Tratamento neonatal com agonista 5-HT1A: repercussões sobre o desenvolvimento da atividade locomotora em ratos
… sua atuação seja intermediada via receptores 5-HT1A. Esta dissertação teve como objetivo estudar as repercussões da manipulação farmacológica, crônica ou aguda, com agonista parcial 5-HT1A, sobre a atividade locomotora em ratos. No primeiro estudo, foi desenvolvido um sistema automático de …
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Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment
… Inhibitor (SSRI) is loss of somatodendritic 5-HT1A receptor-mediated autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to …
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Hindbrain Serotonin Neurons Activate 5-HT1A Receptors in the Nucleus Tractus Solitarius (NTS) to Modulate Sympathetic and Ventilatory Recovery Following Hypotensive Hemorrhage
… are needed.</p><p>Our lab has found that 5-HT1A-receptor agonist, 8-OH-DPAT, increases perfusion pressure and improves acid-base balance in hypovolemic rats by stimulation of sympathetic-mediated increases in venous tone. These data suggest that 8-OH-DPAT may be a promising adjuvant agent in …
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Activation of 5-HT1A Receptors in the Nucleus Tractus Solitarius Facilitate Ventilatory Responses to Hypoxic Hypercapnia and Promote Sympathetic Recovery Following Hypotensive Hemorrhage
<p>The 5-HT<sub>1A</sub> receptor agonist, 8-OH-DPAT, improves recovery from hemorrhage by stimulating sympathetically-mediated venoconstriction and cardiac output. The sympathoexcitatory effect of 8-OH-DPAT is only observed in hypovolemic rats, and is attenuated by sinoaortic denervation. Lesion …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… receptors, taste buds express only the 5-HT1A and 5-HT3 subtypes. The 5-HT1A subtype was found to be expressed in TRCs, while the 5-HT3 subtype is presumed to be expressed in postsynaptic neural elements. Further, 5-HT and the 5-HT1A receptor have been shown to localize in non-overlapping …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… of existing comparative data on serotonin 1A (5-HT1A) receptor signaling in adult hypothalamic rat paraventricular nucleus (PVN).</p> <p>Given the clinical relevance of potential age-dependent differences in serotonergic signaling and regulation of hypothalamic function, the objective of the …
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Estudio de síntesis de 2-[oxoalquil](4-arilpiperazinil)]-benzo[b]tiofenos sustituidos : evaluación de su afinidad serotoninérgica mediante ensayos de competencia frente A [3H]-8-OH-DPAT
… Dentro de los receptores de 5-HT, el subtipo 5-HT1A (un receptor acoplado a proteína G, GPCR) es el mejor estudiado y caracterizado. Múltiples estudios fisiológicos, clínicos, conductuales y farmacológicos han involucrado a este receptor en una amplia variedad de funciones tales como …
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Expression and function of serotonin receptor isoforms in the respiratory system
… Weiterhin konnte gezeigt werden, daß die 5-HT1A, 5-HT7 und µ-Opioid Rezeptoren im PBC ko-exprimiert werden und ebenfalls mittels 8-OH-DPAT (Agonist für 5-HT1A und 5-HT7Rs) Opioid-induzierte Atemdepression kompensiert werden kann ohne Verlust der analgetischen Wirkung der Opioide. Die …
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The effects of chronic ethanol self-administration on the serotonin system in monkeys
… via the serotonin transporter (SERT) and 5-HT1A receptor. Illuminating the mechanisms underlying the effects of chronic ethanol on the SERT and the 5-HT1A receptor in the hippocampus may help to identify additional targets for the treatment of alcoholism.
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Characterisation of novel alpha1-adrenoceptor ligands
… due to a lack of subtype selectivity and the 5-HT1A-R off-target affinity. In this study, computer-aided drug design, structure-activity relationship, and molecular pharmacology methods were used to identify α1A-AR subtype selective compounds with reduced 5-HT1A-R off-target affinity. In silico …
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Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
… spezifisch moduliert. Oligomerisation des 5-HT1A Rezeptors. Die vorliegende Studie analysiert den Oligomerisationszustand des 5-HT1A Rezeptors und untersucht die Oligomerisationsdynamik in lebenden Zellen. Gleichzeitig wurde der Einfluss der Rezeptorpalmitoylierung auf diesen Prozess …
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3,4-Diaminopyridin evozierte Freisetzung von Neurotransmittern aus Hirnschnitten von Ratten
… befassten wir uns mit dem Nachweis von 5-HT1A-Rezeptoren im Hippocampus von Ratten, die nach einer Läsion des serotonergen Systems eine intrahippocampale Transplantation serotonerger Neurone erhielten. <br>Dabei ergaben sich folgende Resultate: <br>1. Sowohl bei denen mit [³H]5-HT, wie …
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Mechanisms of Ipsapirone-Mediated Neuroprotection of Ethanol-Treated Fetal Rhombencephalic Neurons: Role of Endogenous Antioxidants
… However, treatment with a serotonin-1A (5-HT1A) agonist prevents the ethanol-associated apoptosis in developing 5-HT neurons. One mechanism by which 5-HT1A agonists exert their neuroprotective effects appears to involve activation of the phosphatidylinositol 3'kinase (PI-3K) pro-survival …
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New Instrumentation and Methods for Analyzing Biological Compounds for Drug Discovery and Discovering Novel Disease Markers
… pairs. CHO-K1 cell membranes containing 5-HT1A receptors were tethered to sulfonate modified particles. NAN-190, a fluorescent 5-HT1A antagonist, binding to 5-HT1A receptors was monitored using flow cytometry. Liposome shell microparticles may also be used in packed bed membrane-based …
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PET-imaging in depression and antidepressant therapies : focus on the serotonin system and the cerebral glucose metabolism
… the serotonin transporter to the serotonin 5-HT1A and 5-HT2A receptors to explore the role of the serotonin system in the pathophysiology of this depression model in the rat. For this purpose, three radiotracers were applied: [11C]DASB, [18F]MPPF, and [18F]altanserin. This allowed to image the …
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