Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"5-HT receptors"”.
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Differential expression of C/T antigens and 5-HT receptors in normotensive and pre-eclamptic placentae, and their role in trophoblast invasion
… substances including 5-hydroxytryptamine (5-HT). Interestingly, in pre-eclampsia (a pregnancy related multi-system complication), the levels of 5-HT are found to be increased, whilst the overall trophoblast invasion is low, when compared to normal (NT) placenta. Previous studies have compared …
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EFFECTS OF CHRONIC METHYLPHENIDATE ON DOPAMINE/SEROTONIN INTERACTIONS IN THE MESOLIMBIC DOPAMINE SYSTEM OF THE MOUSE
… particular, the effects of MPH on serotonin (5-HT) systems have not been well investigated. While MPH itself does not have affinity for the 5-HT transporter, DA and 5-HT systems have many points of interaction, particularly in the mesolimbic DA system, an area associated with the rewarding and …
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Estrogen and Serotonin – old dogs, new tricks, Implications for pancreatic beta-cell function
Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). When activated, these receptors are able to fine-tune islet …
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A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking
… In contrast, the stimulation of serotonin (5-HT) receptors by 5-HT hydrogen maleate did not affect the relapse to food seeking by the reward-associated cues. Together, these data indicate selective roles for specific NAcc receptor activation in the ability for a reward-paired CS to reinstate …
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In vivo and in vitro aspects of imidazoline-2(1/2)sites within the central nervous system
… of indole alkaloids to serotonin the 5-HT releaser fenfluramine and a number of SSRI's (selective serotonin reuptake inhibitor) were also administered and these compounds gave rise to significant partial (20-80% responses to the 2-BFI lever) levels of substitution. The autoradiographical …
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The ontogeny and functional distribution of novel, neurochemically-defined columns in mammalian visual cortex
… experience. The distributions of serotonin (5-HT) 1A, 1C, 2 and 3 receptor subtypes and the 5-HT uptake site were assessed in postnatal cat visual cortex using in vitro autoradiographic methods. Each5-HT receptor subtype exhibited a unique temporal, regional and laminar pattern of expression. …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ …
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Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
Serotonin (5-hydroxytiyptamine, 5-HT) and its receptors have been demonstrated in ocular tissues including the cornea, iris-ciliary body and retina of various species. The overall objective of the present study was two-fold: (a) to examine the effect of exogenous 5-HT on the release of radiolabeled …