Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"5-HT receptor"”.
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The design and synthesis of novel heterocycles as potential 5-HT receptor ligands
The seven transmembrane α-helices of the human 5 -HT<sub>1A</sub> , 5-HT<sub>1Dα</sub> and 5-HT<sub>1Dβ</sub> receptors have been modelled using the 3-dimensional coordinates of the seven transmembrane a-helices of the bacterial protein bacteriorhodopsin as a template. The probable 5-HT binding …
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The synthesis of WAY-derivatives to find linker location and a new linker to attach a fluorescence tag for homo- or hetero-dimer of 5-HT receptor ligands
… obesity and drug addiction. The serotonin receptor has been studied as a possible target for cocaine addiction therapy. Previously, 5-HT 2A receptor antagonist, M100907 and 5-HT 2C receptor agonist, WAY 163909 have been studied as molecules to control behaviors related to addiction. …
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Characterization of 5-Hydroxytryptamine-Evoked Isometric Contractile Responses in Aortic Vascular Smooth Muscle in Thyropathological Rats
… changes in 5-hydroxytryptamine (serotonergic; 5-HT) receptor function mediating contraction/dilation in rat aorta have not been completely characterized. Procedure. Aortic rings from hyperthyroid (TRX),hypothyroid (PTU), and euthyroid control (CON) rats were mounted in climate controlled tissue …
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Differential expression of C/T antigens and 5-HT receptors in normotensive and pre-eclamptic placentae, and their role in trophoblast invasion
… substances including 5-hydroxytryptamine (5-HT). Interestingly, in pre-eclampsia (a pregnancy related multi-system complication), the levels of 5-HT are found to be increased, whilst the overall trophoblast invasion is low, when compared to normal (NT) placenta. Previous studies have compared …
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The ontogeny and functional distribution of novel, neurochemically-defined columns in mammalian visual cortex
… experience. The distributions of serotonin (5-HT) 1A, 1C, 2 and 3 receptor subtypes and the 5-HT uptake site were assessed in postnatal cat visual cortex using in vitro autoradiographic methods. Each5-HT receptor subtype exhibited a unique temporal, regional and laminar pattern of expression. …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
<p>Serotonin (5-HT) is a ubiquitous neurotransmitter in the brain that is involved in various physiologic functions including the regulation of hypothalamic hormones and has been implicated in various mood disorders such as depression. Preclinical and clinical data from studies in adults have shown …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… cytokine interleukine-1β (IL-1β), serotonin (5-HT) receptor subtypes, and dopamine D2 receptors in the brainstem and cerebellum, as well as to elucidate the role of peripheral MCP-1 in cancer chemotherapy 5-flouracil (5FU)-induced changes in these CNS fatigue-related neural factors. Methods: …
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Serotonin signaling in C. elegans
… slowing response, is partly serotonin (5-HT) dependent. Animals mutant for the 5-HT reuptake transporter gene mod-5 slow even more than wild-type animals because endogenous 5-HT activity is potentiated. This behavior, called the hyperenhanced slowing response, can be suppressed by …
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Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
Serotonin (5-hydroxytiyptamine, 5-HT) and its receptors have been demonstrated in ocular tissues including the cornea, iris-ciliary body and retina of various species. The overall objective of the present study was two-fold: (a) to examine the effect of exogenous 5-HT on the release of radiolabeled …
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Role of 5-ht2c receptor density on behaviour in mice
The neurotransmitters serotonin (5-HT) and dopamine (DA) play roles in eating disorders, mood disorders, such as depression and anxiety, and in the regulation of locomotion. The 5-HT2C receptor is one of fourteen 5-HT receptor subtypes that is expressed in regions of the brain including the …
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Serotonin receptor mechanisms in anti-depressant action
… suggesting the existence of multiple serotonin receptor subtypes and the genes for these receptors, as well as that of the serotonin transporter, have common polymorphic variants. To investigate the effect of repeated treatment with selective serotonin fe-uptake inhibitors (SSRI's) on the …
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Kinetic studies of the spasmogenic effects of serotonin and isolates from Byrsonima crassifolia leaves on rat fundus
… n-butanol-extracted, pargyline- and 1-(1-naphtylpiperazine) (1-NP)-sensitive, atropine-insensitive activity, and (ii) low-efficacy, high-potency, ethyl acetate-extracted, pargyline-insensitive, atropine- and 1-NP-sensitive activity. HOAcE lacked muscarinic and nicotinic effects on rat jejunum …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
Studies investigating the effect of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ …
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DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
… represents a critical intersection fraught with multifaceted social and economic implications. On one front, the emergence of the SARS-CoV-2 virus has precipitated a global health crisis of unprecedented proportions, amplifying preexisting economic vulnerabilities and catalyzing a …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… was much less potent than S-MEPH at serotonin (5-HT) transporters. Locomotor activity was evaluated after acute administration of each enantiomer, with R-MEPH producing greater repetitive movements than S-MEPH across multiple doses. Pretreatment with the 5-HT2C antagonist SB242084 significantly …