Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 164 for “"5-HT"”.
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Estrogen and 5-HT(1A) receptor function
The effects of estrogen treatment on 5-HT1A receptor function were examined. When ovariectomized rats were given a single treatment with 25 μm estradiol benzoate followed 48 hr later with 500 μg progesterone, the 5-HT1A receptor agonist, 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited …
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Die Funktionelle Rolle der Palmitilierung des 5-HT 1A Rezeptor
In dieser Studie wurde demonstriert, dass der 5-HT (1A) Rezeptor durch tioester-type Bindung palmitoyliert ist. Die Palmitoylierung wird nicht durch die Stimulation mit den Agonisten moduliert. Durch die Proteinsynthese Blockierung wurde gezeigt dass die Palmitilierung abhängig von der …
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Serotonin (5-HT) Increases Olfactory Responsiveness in the Tobacco Hawkmoth Manduca sexta
… understand the functional role of serotonin (5-HT), a neuromodulator,on olfactory behavioral responses. In this study, we aimed to identify the functional role of 5-HT in Manduca sexta olfactory function. Using a Pavlovian-Conditioning Paradigm, we conditioned moths to 2-hexanone and tested them …
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Investigating disturbances of brain 5-HT systems by experimental MRI and SPECT neuroimaging
… that target SERT, and a recently discovered 5-HTT gene-linked polymorphic region (5-HTTLPR) of the SERT gene has been shown to predispose to depression, the SERT assumes a key role in depression. Traditionally, depression severity was assessed using psychological testing of patients. However in …
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The design and synthesis of novel heterocycles as potential 5-HT receptor ligands
The seven transmembrane α-helices of the human 5 -HT<sub>1A</sub> , 5-HT<sub>1Dα</sub> and 5-HT<sub>1Dβ</sub> receptors have been modelled using the 3-dimensional coordinates of the seven transmembrane a-helices of the bacterial protein bacteriorhodopsin as a template. The probable 5-HT binding …
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Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins
… the intracellular signalling mechanisms of the 5-HT₂ₐ and related receptors. The Gprotein coupled receptors (GPCRs) are named after their ability to interact with and signal through the trimeric G-proteins. The 5-hydroxytryptamine 2A receptor (5- HT₂ₐR) is a member ofthe group I family of …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… outcomes and extend abstinence. Serotonin (5-HT) neurotransmitter systems play an important role in the behavioral effects of cocaine particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine …
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Role of the Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) in Cocaine Cue Reactivity
… outcomes and extend abstinence. Serotonin (5-HT) neurotransmitter systems play an important role in the behavioral effects of cocaine particularly through the 5-HT2C receptor (5-HT2CR), however, the involvement of this system in incubation of cue reactivity during abstinence from cocaine …
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The Relationship of Testosterone and 5-HT to Aggressive, Self-Aggressive, and Antisocial Behavior in Men
… between T (as well as cortisol and 5-HT) and aggression-related constructs. A second purpose was to determine if 5-HT functioning moderates the relation between T and aggression and related constructs. Participants for the current study were derived from two archival datasets. …
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Exploring the effect of alpha2 receptor on brain 5-HT via a mechanism-based pharmacodynamic model
Purpose: 5-hydroxytryptamine (5-HT) is an important neurotransmitter in depression. It is believed that α 1 and α 2 adrenoceptors mediate the 5-HT level in the brain. The mechanism is complex and not well explored. Especially in different combination treatments, the receptor systems may show varied …
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Design, Synthesis, and Pharmacological Characterization of Serotonin (5-HT) 5-HT2C Receptor (5-HT2CR) Positive Allosteric Modulators
… decreased signaling capacity at the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) regulates neurobehavioral processes that may underlie chronic health issues such as impulsivity disorders, drug addiction, depression, schizophrenia, and obesity. Therefore, restoration of the diminished signaling …
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INDIVIDUAL DIFFERENCES IN IMPULSIVE ACTION AND TEMPORAL ESTIMATION: INTERACTION WITH THE SEROTONIN (5-HT) 5-HT2A RECEPTOR
… and neurotransmitter systems (e.g., serotonin, 5-HT) that regulate impulsive action. Manipulation of the 5-HT2A receptor (5-HT2AR) influences impulsive action and timing functions, suggesting that functional capacity of the 5-HT2AR system may drive the predisposition to inherent impulsive action. …
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Exploring the effects of 5-HT2A and AMPA receptors on brain 5-HT via a mechanism-based pharmacodynamic model
… measure serotonin (5-hydroxytryptamine, 5-HT) levels in human brains, neuroimaging technologies have shown macroscopic structural and functional abnormalities in the prefrontal cortex (PFC) of depressed patients. The monoamine hypothesis of depression is based on the neurotransmitter …
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Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
5-HT3B ist eine Untereinheit des Serotoninrezeptors Typ 3 (5-HT3), einem Ionenkanal aus der Cys-loop-Rezeptorfamilie. Das Gen HTR3B kodiert für 5-HT3B. Der -100_-102delAAG-Polymorphismus im HTR3B-Promotor kann die HTR3B-Promotoraktivität beeinflussen und wurde mit Häufigkeit und Schweregrad von …
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The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… and Medical Consequences (DTMC) recently highlighted the need for pharmacological targets to treat substance use disorders (SUDs) in the near term as well as entirely new mechanistic directions for SUDs research. A hallmark of SUDs is “continued drug use despite adverse consequences,” which …
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Differential expression of C/T antigens and 5-HT receptors in normotensive and pre-eclamptic placentae, and their role in trophoblast invasion
… substances including 5-hydroxytryptamine (5-HT). Interestingly, in pre-eclampsia (a pregnancy related multi-system complication), the levels of 5-HT are found to be increased, whilst the overall trophoblast invasion is low, when compared to normal (NT) placenta. Previous studies have compared …
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The serotonin (5-HT) 2C receptor (5-HT2CR) and its downstream signaling components: Distinct adaptations in cortical circuits associated with cocaine exposure
… addicts. Neuroadaptations in the serotonin (5 HT)2C receptor (5-HT2CR) system, which exerts an inhibitory influence over the limbic-corticostriatal circuitry and has been implicated in modulating cocaine-evoked behaviors, may play a key role in the development and maintenance of behavioral …
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Serotonin 5-HT<sub/>2C</sub> receptors: Role in (+)-MDMA sensitization and distribution in the ventral tegmental area
Serotonin (5-HT) released consequent to acute (+)-3,4-methylenedioxy-methamphetamine [(+)-MDMA; \"ecstasy\"] administration stimulates 5-HT<sub/>2C</sub> receptors (5-HT<sub/>2C</sub>R) to exert inhibitory influence on (+)-MDMA-induced behaviors. Thus, changes in 5-HT<sub/>2C</sub>R responsiveness …
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