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Showing 1 to 20 of 82 for “"5-Fluorouracil"”.
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A MOLECULAR ORBITAL STUDY OF 5-FLUOROURACIL AND RELATED COMPOUNDS
<p>5-fluorouracil is a chemotherapeutic agent which is used in the treatment of disseminated colon and breast cancers. As an antimetabolite it has been found to inhibit the mechanism in which the normal substrate reacts with the enzyme and a cofactor in nucleic acid synthesis. A number of …
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An investigation of the release of 5-fluorouracil from ointment bases
<p>During the several years in which this therapy has been developed and evaluated, as standard dermatological preparation has not been available. The objective of the present work was to study the release of 5-FU from various ointment bases and to attempt to determine the type of base which would …
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Effects of 5-Fluorouracil Chemotherapy On Fatigue and Inflammation In Mice: Benefits of Quercetin
<p>Effects of 5-Fluorouracil Chemotherapy on Fatigue and Inflammation in Mice: Benefits of Quercetin Cancer related fatigue is one of the most distressing symptoms reported by cancer patients, however little research has been done to elucidate the cause(s) of this debilitating condition. Because …
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The Study of Positive-Ion Mass Spectrometry of 5-Fluorouracil Using Low-Energy Electron Impact
… thesis was to generate a molecular beam of 5-fluorouracil and to investigate the fragmentation processes that were induced by low-energy electron impact. The apparatus is contained in a vacuum chamber with three main compartments: the expansion chamber, the collision chamber and the …
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Trabekulektomie vs. Trabekulektomie mit intraoperativer 5 Fluorouracil Applikation bei Patienten mit primaerem Glaukom in Kambodscha
In der vorliegenden Arbeit wurden prospektiv 40 Augen von 34 Patienten operiert und untersucht, aufgeteilt in eine Gruppe von 20 Augen, die eine konventionelle Trabekulektomie erhalten hat und eine weitere Gruppe von 20 Augen, bei der intraoperativ 5 FU appliziert wurde. Es waren kambodschanische …
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The Effects of 5-Fluorouracil on The Secretory Process of The Rat Parotid Gland (Protein)
… were injected intraperitoneally with 100 mg/kg 5-fluorouracil for three days. The total volume, amylase and protein content of cannulated parotid saliva were determined following stimulation with either 5 mg/kg pilocarpine or 5 mg/kg isoproterenol in experimental, pair-fed, and control animals. …
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The Effects of 1,25-Dihydroxyvitamin D3, Docosahexaenoic Acid and 5-Fluorouracil on Human Breast Cancer Cells
… combinations for 72 hours. Both DHA and 5-Fluorouracil slowed growth significantly (p < 0.05). In contrast, vitamin D did not inhibit cell growth at 1 μM. The combination of vitamin D and DHA inhibited cell growth slightly more than DHA alone. Interestingly, DHA was just as effective as …
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Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
Breast cancer is one of the leading causes of deaths in women worldwide. 5-flourouracil (5-FU) is a classic chemotherapeutic drug that has been widely used in the treatment of breast cancer patients. In this study, using several biochemical techniques, we studied the global effects of 5-FU …
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Expression of Bax Predicts Outcome in Advanced Gastric Cancer Patients Treated With 5-fluorouracil and Platinum Palliative Chemotherapy
… with advanced gastric cancer treated with 5-fluorouracil (5-FU) and platinum palliative chemotherapy. Materials and Methods: One hundred and twenty-eight patients with metastatic or recurrent gastric cancer were treated with a chemotherapy regimen of either 5-FU and heptaplatin (FH) (56 …
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Dichloroacetate, a inhibitor of pyruvate dehydrogenase kinase-1, attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer cells
… cancer with hypoxia-induced resistance to 5-fluorouracil (5-FU) could be re-sensitized following treatment with low-dose dichloroacetate (DCA), an inhibitor of the glycolytic pathway. The expression profile of hypoxia-inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase-1 (PDK-1) …
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Immunospecific albumin microspheres as a drug delivery system for cisplatin and 5-fluorouracil for the treatment of ovarian adenocarcinoma
… the chemotherapeutic agents, cisplatin and 5-fluorouracil, for the treatment of ovarian adenocarcinoma. A rodent cell line, as a model, has proved to be similar to its human counterpart and also has shown to be transplantable from one animal to another. Such a model could therefore be useful …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
5-fluorouracil(5-FU) is one of the chemotherapeutic agents that has been used widely in gastric cancer. However, the responsiveness of 5-FU has been limited for several gastric cancer patients, and this limitation is believed to be caused by chemoresistance. To date, the mechanism of …
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Chemotherapeutic drugs, 5-fluorouracil and cisplatin, differentially affect exprssion of drug metabolising enzyme genes in an oesophageal cancer cell line
Cancer is a leading cause of death worldwide. Oesophageal cancer in particular is the sixth most common cause of cancer deaths globally and its incidence and mortality rates in Southern Africa are among the highest in the world. One of the major challenges with cancer treatment is the vast …
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Einschluss von 5-Fluorouracil (5-FU) in vesikuläre Phospholipidgele : in vitro und in vivo Untersuchungen zur Stabilität, Pharmakokinetik und antitumoralen Wirksamkeit
Im Rahmen der Arbeit sollte untersucht werden, ob die antitumorale Therapie mit 5-FU durch den Einschluss des Wirkstoffes in vesikuläre Phospholipidgele (VPG) im Vergleich zur konventionellen Therapie mit 5-FU-Injektionslösung effizienter gestaltet werden kann. Grundlage für die in vivo Versuche …
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Tailored chemotherapy based on genomic polymorphisms for metastatic colorectal cancer treated with 5-fluorouracil plus oxaliplatin or irinotecan in Korean patients
배경: 옥살리플라틴과 이리노테칸은 전이성 대장암 환자에서 5-FU와 함께 투여하여 FOLFOX 또는 FOLFIRI용법으로 일차치료로서 가장 많이 사용되는 항암제이다. 본 연구의 목적은 전이성 대장암 환자에서 전향적 연구로서 항암제와 연관된 유전자 다형성을 분석하고 환자에 맞는 약제를 선택하여 일차치료를 진행하여 이에 대한 반응도를 알아보기로 하였다. 방법: 50명의 전이성 대장암 환자에서 말초혈액을 통해 유전자 다형성을 분석하였다. PCR-based RFLP 방법을 사용하여 TS, MTHFR-977, XPD-751, …
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