Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"5-FU"”.
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Prädiktives und prognostisches Potential der Thymidylatsynthase als Biomarker im multimodalen Therapiekonzept 5-FU-basierter Radiochemotherapie des lokal fortgeschrittenen Rektumkarzinoms
Hintergrund 5-Fluorouracil (5-FU) ist ein wichtiger Bestandteil der Radiochemotherapie (RCT) des lokal fortgeschrittenen Rektumkarzinoms. Thymidylatsynthase (TS) als Hauptwirkort von 5-FU wird als Biomarker zur Responsprädiktion und für die Langzeitprognose disskutiert. In dieser Analyse wurde die …
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Einschluss von 5-Fluorouracil (5-FU) in vesikuläre Phospholipidgele : in vitro und in vivo Untersuchungen zur Stabilität, Pharmakokinetik und antitumoralen Wirksamkeit
… werden, ob die antitumorale Therapie mit 5-FU durch den Einschluss des Wirkstoffes in vesikuläre Phospholipidgele (VPG) im Vergleich zur konventionellen Therapie mit 5-FU-Injektionslösung effizienter gestaltet werden kann. Grundlage für die in vivo Versuche stellte die in vitro …
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DNA Damage and Cell Death Mediated by Thymidylate Synthase Inhibitors: Role of UNG and SMUG1 DNA Glycosylase
… chemotherapeutics such as 5-fluorouracil (5-FU) remain one of the most widely used agents for management of cancer in clinic. Currently, 5-FU is approved in USA for therapy of various cancers including that of colorectal and breast. Pharmacological actions of 5-FU are mediated by …
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Regulation of cytotoxic drug-induced apoptosis by death receptor 5 in human colon cancer cells
5-Fluorouracil(5-FU)is a cytotoxic drug that is widely used for the treatment of colon cancer. However, 5-FU-resistance is still a common issue which needs to be overcome. Understanding the molecular pathway of 5-FU-induced apoptosis will help designing more effective cancer treatments. …
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Effects of 5-fluorouracil Drug Treatment on the Expression Profile of MicroRNAs in MCF7 Breast Cancer Cells
… of deaths in women worldwide. 5-flourouracil (5-FU) is a classic chemotherapeutic drug that has been widely used in the treatment of breast cancer patients. In this study, using several biochemical techniques, we studied the global effects of 5-FU treatment on MCF7 breast cancer cells. The …
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Novel Oligomeric Fluoropyrimidines and Their Efficacy for the Treatment of Colorectal Carcinoma Independent of p53 Mutation
… standard of care, including 5-fluorouracil (5-FU). Resistance to 5-FU is unfortunately frequent in CRC partially due to the dependency 5-FU displays towards normal p53 function, a tumor suppressor protein that is commonly mutated in advanced CRC. In addition to the relatively low success rate …
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Biochemical and Molecular Characterisation of the FADDosome
An anti-metabolite drug, 5-FU (5-fluorouracil), is widely used in the treatment of colorectal cancer. However, acquisition of resistance by cancer cells is the main cause of the limited clinical use of 5-FU, which needs to be overcome to widen and lengthen its utility. Therefore, it is necessary to …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
5-fluorouracil(5-FU) is one of the chemotherapeutic agents that has been used widely in gastric cancer. However, the responsiveness of 5-FU has been limited for several gastric cancer patients, and this limitation is believed to be caused by chemoresistance. To date, the mechanism of …
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Dichloroacetate, a inhibitor of pyruvate dehydrogenase kinase-1, attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer cells
… hypoxia-induced resistance to 5-fluorouracil (5-FU) could be re-sensitized following treatment with low-dose dichloroacetate (DCA), an inhibitor of the glycolytic pathway. The expression profile of hypoxia-inducible factor-1α (HIF-1α) and pyruvate dehydrogenase kinase-1 (PDK-1) were analyzed in …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after 5-FU treatment between patients with …
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Identifying potential genetic, phenotypic and epigenetic predictive markers in the Toll-like receptor/Interleukin-1 domain innate immune signalling pathway for severe gastrointestinal toxicity risk following 5-Fluorouracil-based therapy
… adverse side effects following 5-fluorouracil (5-FU)-based therapy. Current supportive care measures for the treatment of severe GI toxicity are limited, with many patients requiring treatment intervention or hospitalisation to help manage and relieve symptoms. The presence of severe GI toxicity …
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Methods to Probe the Function of Modified Bases in DNA
… of chemical and biological tools to probe the function of modified bases in DNA with specific exploration of the less well-studied T-modifications: 5-hmU, 5-fU and Base J. LCMS/MS techniques are first utilised to enable the accurate global quantification of T-modifications (5-hmU, 5-fU and Base …
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Trabekulektomie vs. Trabekulektomie mit intraoperativer 5 Fluorouracil Applikation bei Patienten mit primaerem Glaukom in Kambodscha
… Gruppe von 20 Augen, bei der intraoperativ 5 FU appliziert wurde. Es waren kambodschanische Patienten, die bisher keine antiglaukomatöse Lokaltherapie erhalten hatten und kein erhöhtes Vernarbungsrisiko aufwiesen. Die Mehrzahl der behandelten Augen (31) wies dabei ein chronisches …
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Toll-Like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice
… by radiation. Here, using 5-Fluorouracil (5-FU) treated mice as a model of chemotherapy-induced side effects; I demonstrated significant reduction in the severity of 5-FU-induced morbidity. Increased survival was accompanied by the improved integrity of intestinal tissue and the restoration …
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Dual Targeting of Tumor Angiogenesis and Chemotherapy By Endostatin- Cytosine Deaminase-Uracil Phosphoribosyltransferase
… developed a novel anti-tumor therapeutic EndoCDfusion protein which linked endostatin (Endo) to cytosine deaminase-uracilvphosphoribosyl transferase (CD). Endo targets unique tumor endothelial cells toprovide tumor-specific antiangiogenesis activity and also carries CD to the localtumor area, …
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A multi-compartment pharmacokinetic model of 5-fluorouracil and dihydrofluorouracil
5-Fluorouracil (5-FU) is extensively biotransformed to dihydrofluorouracil (DHFU) by the dihydropyrimidine dehydrogenase enzyme (DPD) that catalyzes the reduction of uracil and thymine. This research involves the development of intensive quantitative compartment models that predict the time course …
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Probiotic-derived factors as potential chemopreventive agents for intestinal mucositis and colon cancer
… mucositis. Mucositis is the term for painful inflammation and ulcerating lesions of the mucous membranes lining the digestive tract. Intestinal mucositis is a common side-effect of cancer chemotherapy. To date, there are no satisfactory clinical treatments available to combat mucositis and …
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Expression of Bax Predicts Outcome in Advanced Gastric Cancer Patients Treated With 5-fluorouracil and Platinum Palliative Chemotherapy
… gastric cancer treated with 5-fluorouracil (5-FU) and platinum palliative chemotherapy. Materials and Methods: One hundred and twenty-eight patients with metastatic or recurrent gastric cancer were treated with a chemotherapy regimen of either 5-FU and heptaplatin (FH) (56 patients) or 5-FU, …
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