Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"5'-nucleotidase"”.
-
Investigation of Transcriptional Regulation of 5'-Nucleotidase in Dictyostelium Discoideum
… prespore zones. This enzyme is referred as 5'-Nucleotidase (5NT). Given the critical role of cyclic AMP in cell differentiation in this organism, 5NT is thought to be involved in cell positioning during development. Southern blot analysis showed a single form of the gene. The expression of the …
-
The Role of 5' Nucleotidase in the Regulation of Morphogenesis in Dictyostelium Discoideum
5' Nucleotidase (5NU) in <i>Dictyostelium discoideum</i> is an enzyme that shows high substrate specificity to 5'AMP. The enzyme has received considerable attention in the past because of the critical role played by cyclic AMP in cell differentiation in this organism. Degradation of cAMP by cAMP …
-
Identification of Regulatory Binding Sites and Corresponding Transcription Factors Involved in the Developmental Control of 5'-nucleotidase Expression in Dictyostelium discoideum
… mechanisms. The developmental control of 5â -nucleotidase (5nt) expression in the model system Dictyostelium discoideum has provided a focal point for studies of gene regulation at the level of transcription. In order to identify temporally-regulated control elements within the promoter of the …
-
The Development of Certain Enzymes and Iso-Enzymes During Normal Pregnancy
… alkaline phosphatase, glucose-6-phosphatase, 5-nucleotidase, n-acetyl-β-glucosaminidase, n-acetyl-β-galactosaminidase and β-glucuronidase, have been found to progressively increase. Dipeptidase and tripeptidase were not found to increase during pregnancy. A wide scatter of results was found …
-
Η ΣΗΜΑΣΙΑ ΤΟΥ ΠΡΟΣΔΙΟΡΙΣΜΟΥ ΩΡΙΣΜΕΝΩΝ ΒΙΟΛΟΓΙΚΩΝ ΠΑΡΑΜΕΤΡΩΝ ΣΤΗ ΜΕΛΕΤΗ ΤΟΥ ΚΑΡΚΙΝΟΥ
… gamma-glutamyl transpeptidase, 5'-nucleotidase, and carcinoembryonic antigen were determined in 256 cancer patients in order to evaluate their significance in diagnosis and patient monitoring. Our results indicate that in most cases there is a marked increase of …
-
Efeitos de crises crônicas e agudas induzidas por pentilenotetrazol sobre a hidrólise de nucleotídeos púricos em soro de ratos adultos
… as enzimas ATP difosfoidrolase (CD39) e 5’-nucleotidase (CD73). Embora esta associação enzimática já esteja bem descrita, o envolvimento da enzima fosfodiesterase não pode ser descartado, uma vez que esta hidrolisa nucleotídeos como ATP e ADP, além de outros substratos. Recentemente, foi …
-
Derivados da guanina e a modulação da captação astrocitária de glutamato
… Quando utilizamos um inibidor da ecto-5’-nucleotidase, o efeito do GMP na captação de glutamato desaparece e não houve interferência no efeito da GUO. Assim, esses resultados sugerem que a GUO é o derivado da guanina responsável pelo efeito na captação de glutamato. Ao mesmo tempo, os …
-
A Putative Cytosolic Saxitoxin Binding Protein in Frog Myocardium
… is only 25% retained, 6% in F1. Total 5'-nucleotidase activity is only 5% retained, less than 1% in F1. Sugar containing proteins detectable by periodic acid-Schiff base (PAS) staining of non-detergent (buffer) gels are found in F1. Proteins in F1 are associated with an appreciable amount …
-
Aspects of purine and pyrimidine metabolism
… IMP accumulation, namely PRPP synthetase and 5'-nucleotidase. These metabolic properties suggest that the erythrocyte could play a role in the removal of hypoxanthine from anoxic tissue. In Chapter 3 the kinetics and mechanism of transport of orotate across the human erythrocyte membrane and the …
-
Identificação das características cinéticas, expressão e localização das ecto-nucleotidases em cultura de astrócitos e linhagens de gliomas
… sinalização purinérgica são reguladas pelas ecto-nucleotidases, que incluem membros da família das ecto-nucleosídeo trifosfato difosfoidrolase (E-NTPDase), ecto-5’-nucleotidase (ecto- 5’N) e ecto-adenosina deaminase (ADA). Culturas de astrócitos preparadas de hipocampo, córtex e cerebelo de ratos …
-
Charakterisierung der initialen Aufnahme des Kofaktors V (NAD) bei Haemophilus influenzae
H. influenzae ist ein fakultativ anaerobes, Gram-negatives Bakterium und wird in die Familie der Pasteurellacaea eingeordnet. Das Bakterium zeigt Auxotrophien für Hämin unter aeroben Bedingungen und für Nikotinamid-Adenin-Dinukleotid (NAD) bei aeroben wie anaeroben Wachstum. Es können zwei …
-
Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… signalling (entpd2_mg, entpd2_mq, and 5′-nucleotidase). These findings suggest that arsenic-induced cognitive dysfunction arises from oxidative imbalance and disruption of dopamine neurotransmission. Chapter 3 explored the intergenerational and transgenerational inheritance of these …
-
Rat Lymphocyte Surface Glycoproteins Mediating Mitogenesis by Periodate or Neuraminidase Plus Galactose Oxidase
… distributed with the plasma membrane markers: 5'-nucleotidase, γ-glutamyl transpeptidase, and alkaline phosphodiesterase. The labeling was shown to be specific and uniform for all oxidized components; radioactive Schiff base adducts could not be detected following <sup>3</sup>H-borohydride …
-
ΛΕΙΤΟΥΡΓΙΚΟΤΗΤΑ ΤΟΥ ΑΓΓΕΙΑΚΟΥ ΠΝΕΥΜΟΝΙΚΟΥ ΕΝΔΟΘΗΛΙΟΥ, IN VIVO, ΥΠΟ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΣΥΝΘΗΚΕΣ
BESIDES GAS EXCHANGE, THE PULMONARY CIRCULATION HAS ANOTHER IMPORTANT FUNCTION,A METABOLIC ONE. PULMONARY VASCULAR ENDOTHELIUM PARTICIPATES IN VARIOUS IMPORTANT PHYSIOLOGIC AND PHARMACOKINETIC PROCESSES WHICH ARE SUSCEPTIBLE TO DIFFERENT PHARMACOLOGICAL, PHYSICAL AND TOXIC AGENTS. UNDER …