Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"5'-deoxyadenosine"”.
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Mechanistic aspects of thiamine biosynthesis in escherichia coli
… phase kinetics. The SAM cleavage products (5‘-deoxyadenosine (DOA) and methionine) were identified as inhibitors of ThiH activity and this inhibition could be alleviated by addition of 5‘-methylthioadenosine / S-adenosylhomocysteine nucleosidase (MTAN), which catalysed rapid hydrolysis of DOA …
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Exploring Prokaryotic Thiamin Biosynthesis: Mechanistic Studies On Thiamin Thiazole Synthase And Pyrimidine Synthase
… were thus identified to be HMP-phosphate and 5'-deoxyadenosine. We were also able to establish the fate of all the C atoms of the substrate, and have other insights into the mechanism of this complex enzyme with regard to the unprecedented rearrangement it brings about. Further mechanistic …
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Methanocaldococcus jannaschii and the Recycling of S-adenosyl-L-methionine
… (SAH), methylthioadenosine (MTA), and 5'-deoxyadenosine (5'-dA). Each of these has been demonstrated to be feedback inhibitors of SAM dependent enzymes. Thus, each metabolite has a pathway to prevent inhibition through the salvage of nucleoside and ribose moieties. However, these salvage …