Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"5' AMP-activated protein kinase"”.
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AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
… to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated protein kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells harbouring low numbers of mtDNA …
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Identification and Targeting of Downstream Ar-Camkk2-Mediated Mechanisms For The Treatment of Advanced Prostate Cancer
… Previously, Ca<sup>2+</sup>/calmodulin-dependent protein kinase kinase 2 (CAMKK2) was identified as an essential downstream component of AR signaling in prostate cancer that correspondingly tracked with disease progression. While the importance of CAMKK2 in AR-mediated prostate cancer progression …
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A Molecular and In Vivo Investigation of Advanced Prostate Cancer: Deconstructing Ampk Activity and Developing An Improved Mouse Model
… in prostate cancer, calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is a direct downstream target of AR, and can promote disease progression through the phosphorylation and activation of the 5’ AMP activated protein kinase (AMPK). AMPK is a major regulator of cell homeostasis. While it is …
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Nuclear respiratory factor 1: a novel inhibitor of the human gene promoter of the cardiac isoform of acetyl-coenzyme a carboxylase
… of nuclear genes encoding mitochondrial proteins. Activation of 5'-AMP-activated protein kinase (AMPK) has been associated with enhanced NRF-1 gene promoter binding activity. Furthermore, NRF-1 has been linked with increased gene expression of carnitine palmitoyltransferase-1 (CPT-1), the …
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EFFECTS OF EXERCISE PRECONDITIONING ON MUSCLE HYPERTROPHY AND MITOCHONDRIAL REMODELING FOLLOWING THE SUBSEQUENT RESISTANCE TRAINING
… progenitor cells, which promotes essential protein synthesis following subsequent muscle training. As a highly energy demand tissue, the successful hypertrophy of muscle fiber depends on mitochondrial biogenic progression. Moreover, the majority of genes that encode mitochondrial proteins …
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Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling
… receptor. Our lab has identified heat shock protein 90 (HSP90) as a key regulator of opioid signaling by demonstrating that when HSP90 is inhibited in spinal cord using 17-AAG, ERK MAPK signaling, and subsequent opioid anti-nociception is enhanced. Quantitative proteomic analysis on the …
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Regulation of Systemic and Cellular Metabolism In Prostate Cancer By Camkk2 and Elucidation of Atgl’S Role In Disease Progression
… a gene coding for the serine/threonine kinase Ca<sup>2+/</sup>calmodulin-dependent protein kinase kinase 2 (CAMKK2), a protein upregulated in advanced prostate cancer. CAMKK2 modulates many of its pathological effects through the phosphorylation and activation of the 5' AMP-activated …
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… acid receptors (AMPARs) are ligand-gated glutamatergic ion channels that mediate most excitatory neurotransmission in the brain. Alterations in AMPAR synaptic accumulation mediate synaptic plasticity, including long-term potentiation, long-term depression and …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… fed for 28 d. Distal ileum, cecum, and colon samples were collected for Ussing chamber, histomorphology, and qRT-PCR analyses. The effects of treatment were tested using the Mixed Models procedure of SAS. Among treatments, mice fed scFOS and inulin had greater (p<0.05) intestinal transmural …