Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 95 for “"4e"”.
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Role of 4E-BP2 in neuronal translation
… synaptic plasticity, learning and memory. 4E-BP2 (Eif4ebp2, Eukaryotic Initiation Factor 4E-Binding Protein 2) is the predominantly expressed 4E-BP in the mammalian brain and represses cap-dependent translation initiation, by binding to eIF4E (Eif4e, eukaryotic Initiation Factor 4E). As a …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… phosphoprotein, eukaryotic initiation factor 4E (eIF4E) is considered to be both rate and process limiting. We describe for the first time, the biological role of eIF4E (new biology) in metastatic osteosarcoma. We employed a comparative approach to study the biology of metastasis in …
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Die Synthese von (2Z,4E)-Diencarbonsäureestern und ihre Anwendung in der Totalsynthese von Polyacetylenen
… (RBRV-Sequenz) zur Synthese von (2Z,4E)-Diencarbonsäureethylestern ausgehend von Butenoaten. Dazu wurde zunächst die RBRV-Sequenz optimiert. Diese aus drei Schritten bestehende Sequenz konnte in einem Eintopf-Verfahren angewendet werden. Die Ringschlussmetathese gelang mit einer …
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CHARACTERIZATION OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (eIF4E) FAMILY MEMBERS IN THE ZEBRAFISH (Danio rerio)
The present study examines the six eIF4E cognates in zebrafish. In addition to the prototypical translation initiation factor eIF4E, eukaryotes have evolved eIF4E variants with distinct characteristics, some of which negatively regulate the recruitment of specific mRNAs. Metazoan eIF4E family …
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Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function
Expression of eukaryotic initiation factor 4E (eIF4E) is necessary for active cellular growth and catalysis of the rate-limiting step in cap-dependent protein synthesis3-5. Studies in the past decade have shown that eIF4E contributes to malignancy by selectively facilitating the translation of a …
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The effect of eight tensides on the toxicity of diazinon topically applied to the male German cockroach
… evaluated for comparison. These were Diazinon 4E, Diazinon 4E plus Igepal CO-630, Oiazinon 4E plus Multi-Film X-77, diazinon in OMSO, diazinon in Stoddard's Solvent, and diazinon in Stoddard's Solvent plus piperonyl butoxide. Five of the tensides formed emulsions that were similar in toxicity …
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Point mutational examination of eukaryotic initiation factor 4E (eIF4E), inclusion bodies analysis, and Barley Yellow Dwarf Virus (BYDV) exonuclease resistant RNA structure mapping and prediction
<p>Eukaryotic initiation factor 4E (eIF4E) binds the 5’m7GTP cap structure of mRNA in order to facilitate effective translation. Recessive eIF4E alleles harboring naturally occurring point mutations have been associated with resistance to viral infection, particularly in members of the genus …
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Identificação dos genes eIF4E e eIF(iso)4E em Solanum habrochaites f. glabratum e introgressão do alelo de resistência ao PepYMV(Pepper yellow mosaic virus)em tomateiro
… fator de iniciação da tradução eucarióticos eIF4E e eIF(iso)4E, que levam à resistência recessiva ao vírus, por meio da redução ou mesmo da ausência da multiplicação viral. Os objetivos deste trabalho foram: i) identificar os alelos eIF4E e eIF(iso)4E encontrados no acesso de tomate silvestre …
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
… 1 (mTORC1) signalling, which phosphorylates 4E-Binding Protein 1 and 2 (4E-BPs) to promote synaptic plasticity. This thesis examines the role of 4E-BP signalling in excitatory forebrain (Camk2a-positive) neurons in behavioural and endocrine responses to acute (ARS) and chronic (CVS) stress, …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… eukaryotic translation initiation factor 4E-binding protein 1(4E-BP1)의 발현과 인산화는 HepG2.2.15세포에서 증가하였다. Huh7 HBV WT stable 세포에서는 S6K1의 인산화, PP2A의 발현과 인산화가 증가하였다. AMPK alpha 2가 과발현 될 때 HBV의 core particle과 그 속의 핵산, HBV의 DNA가 감소하였다. HepG2.2.15 세포에 metformin을 처리하였을 때 AMPK의 인산화는 증가하였고 이에 따라Akt, …
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Inhibition of Culex pipiens (L.) (Diptera: Culicidae) emergence with methoprene
Methoprene (isopropyl (2E, 4E)-11-methoxy-3, 7, 11-trimethyl- 2, 4-dodecadienoate) formulated as Altosid® SR-10 was tested against Culex pipiens L. under simulated field conditions and against Aedes aegypti (L.) in the laboratory. Rates from 0.0027 to 0.27 1b. a.i./A resulted in 90 to 100% …
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Reshaping the learning and formative assessment processes of Master of Applied Professional Studies (MAPS) students in the age of AI.
… courses. The study was guided by the 4E GenAI adoption framework developed by Shailendra et al. (2024) to examine students’ experiences and perceptions. The findings informed GenAI adoption within the MAPS programme and can support the development of related policies and procedures at …
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The Construction and Applications of Modular Equations
… any positive real numbers n and k, define hk,n=4e-p n/k k1/44e-p nk=q 30,-n/k k1/4q30, -nk and h'k,n=4 -e-2pn/k k1/44-e-2p nk =q30,1+2-n/ kk1/4q 30,1+2-nk . We show how they are connected with rk,n, r'k,n and Ramanujan-Weber class invariants and give some new theta-function identities. In …
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Isolierung und Strukturaufklärung terpenoider Inhaltsstoffe aus Montanoa hibiscifolia und Oyedaea verbesinoides sowie Untersuchungen ihrer biologischen Aktivität
… ’R-Epoxy-2’-methylbutyryloxy)-9b-hydroxy-germacra-4E,1(10)E-dien-6b,12-olid (8), 8a-(2’S,3’S -Epoxy-2’-methylbutyryloxy)-9b-hydroxy-germacra-4E,1(10)E-dien-6b,12-olid (9), 9b-(2’S,3’S-Epoxy-2’-methylbutyryloxy)-8a-hydroxy-germacra-4E,1(10)E-dien-6b, 12-olid (10), …
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Stereocontrolled synthesis of plant growth regulators Abscisic acid and Xanthoxin
… the double bond system in the side chain, the 2Z,4E-isomers being most potent.
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Évaluation de l'impact d'interventions inspirées d'un modèle d'éducation relative à l'environnement sur les représentations et la relation aux marais d'élèves de 4e année
… et la relation aux marais d'élèves de 4e année. La revue de la littérature dans plusieurs domaines tels le constructivisme, les théories de la connaissance, la sensibilité environnementale et l'attachement aux lieux a permis de situer les représentations du milieu et la relation à …
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Mechanism-Based Strategies to Enhance The Actions of A
… status of the translation repressor 4E-BP1, whose activity is modulated by upstream kinases sensitive to changes in ATP levels, were also performed. The hypophosphorylated state of 4E-BP1 leads to translation repression. Data indicated that treatment with 17-AAG alone resulted in a …
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The ZZ → 4l process and anomalous triple gauge couplings with ATLAS at the LHC
… are selected in the three decay channels, $4e$, $2e2\mu$ and $4\mu$. The cross section of the $ZZ\rightarrow 4\ell$ process is measured in four fiducial regions closely matching the detector acceptance: one for each decay channel ($4e$, $2e2\mu$ and $4\mu$) and one for the combination of all …
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Translational tuning pre-emptively modulates protein folding and secretory pathway defects
… the impact of knock down of an Eap1 ortholog, 4E-HP, on biogenesis of CFTR, using a flow cytometry assay. Knock down of 4E- HP does not have a detrimental impact on CFTR synthesis, suggesting that 4E-HP is not directly analogous to Eap1 and that mammalian cells likely have a more nuanced …
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