Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"4T1 cells"”.
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Astaxanthin Decreases Invasion and MMP Activity in Triple Negative Breast Cancer Cells
… of triple-negative breast cancer (TNBC) cells. We determined that Astaxanthin decreases invasion of 4T1 cells through Matrigel<sup>TM</sup>, but does not affect proliferation. Using zymography we showed that 4T1 cells treated with Astaxanthin demonstrate decreased MMP-2, -9, and -13 …
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Metabolic-response assessment of metastatic murine breast cancer in 2D and 3D cultures using intrinsic NADH as a natural biomarker
The majority of in vitro studies of living cells are routinely conducted in a two-dimensional (2D) monolayer culture towards pathophysiological investigation, drug screenings, and cancer diagnostics. There is strong evidence, however, that suggests cellular behavior and metabolism in 2D cell …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
… motifs are specific to angiogenic endothelial cells and solid tumor cells as a result of their interaction with aminopeptidase N (APN), or CD13, receptors. Fmoc solid phase chemistry was employed via a peptide synthesizer to produce mPeg-CNGRC-mal free peptide that was then cyclized and …
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Development and Characterization of an Autologous Whole Cell Breast Cancer Vaccine
… vaccine may be able to eliminate remaining tumor cells following primary treatment, prevent a recurrence and result in improved survival. </p> <p>We developed an autologous breast cancer vaccine using two murine cell lines, 4T1 and EMT6, to demonstrate the potential of vaccines for adjuvant …
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The potential antioxidant and anticancer properties of polyamines and their response to high-intensity ultrasonication
Polyamines are widespread in living cells and play several important roles in both plants and animals. The polyamines spermine, spermidine and putrescine have been of primary interest, as they participate in cell growth and proliferation and thus are involved in health, disease and aging. …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… the most advanced stage of BC, stage IV, cancer cells metastasize from the original site to distant organs, such as bone, lung and liver. Tumor metastasis is responsible for nearly all of the morbidity and mortality associated with BC. Treatments of BC fail in the advanced stage, when metastases …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. Despite its clinical implications, the mechanisms governing lymphatic metastasis remain poorly understood. This …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… of breast cancer. For these studies, we used 4T1 mouse mammary tumor cells as a model which mimics human breast cancer. First, we investigated the role of Tyk2 tyrosine kinase in the pathogenesis of breast cancer. Here we show for the first time that compared with wild type mice, Tyk2 -/- mice …
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
… to establish the function of Id1/3 in the 4T1 breast cancer cell line and to identify Id1/3 target genes. Thirdly, the requirement of Id1/3 in controlling mammary tumour growth and metastasis was determined by conditional knockdown of Id1/3 expression during tumour progression. The data …
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Rerouting Pre-Existing Host Vaccine-Induced Immunity to wards Breast Cancer
… that may bypass host immune tolerance to cancer cells. We hypothesize that host T-cell immunity acquired through vaccination against or natural infection with infectious diseases—e.g., influenza—can be re-routed to breast cancer cells if the cancer cells also express the vaccine antigens and …
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The effect of dietary genistein on breast cancer metastasis
… soy isoflavone, genistein, on the metastasis of 4T1 murine BC cells implanted in ovariectomized (OVX) BALB/c mice (OVX mice mimic the postmenopausal age group). I hypothesized that weakly estrogenic genistein will enhance BC metastasis based on our previous studies. This study was conducted in …