Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"4R"”.
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Forças motrizes da transferência de vermelho 40 e vermelho ponceau 4R em sistemas aquosos bifásicos
… azoicos Vermelho 40 (V-40) e Vermelho Ponceau 4R (VP-4R) nos SABs formados por poli (óxido de etileno) + sal + água foi estudada. Para uma melhor compreensão do processo de partição distintos efeitos como a dependência de K com a concentração do corante, a massa molar, o efeito do ânion, cátion …
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Development of new GABA uptake inhibitors derived from proline or from pyrrolidin-2-yl acetic acid
… inhibitors. L-trans-4-hydroxypyrrolidine [(2S,4R)-25] was chosen as a precursor, from which the four key intermediates (2S,4R)-38, (2R,4R)-38, (2S,4R)-86 and (2R,4R)-64 were synthesized. The known compounds (2S,4R)-38 and (2R,4R)-38 were prepared from (2S,4R)-25 according to literature …
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Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
… tau), whereas the other half has four repeats (4R tau).</p> <p>Site-directed spin labeling of recombinant tau in conjunction with electron paramagnetic resonance spectroscopy was used to obtain structural insights into tau filaments. The studies showed that the filaments of 4R tau and 3R tau …
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Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised in Asian Americans
… humility, and emotional restraint. The SATAQ-4R is a widely-used measure of sociocultural influences on body image and eating disturbance, which includes different forms for females and males. However, few studies have performed a psychometric evaluation of the SATAQ-4R among Asian Americans. …
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Insecticida natural para el control de Musca doméstica en base a aceites esenciales y sus componentes
… de los AEs estudiados. Entre los Ts, (4R)-(+)-pulegona, 1,8 cineol, -terpineno y (4R)(+)-limoneno, resultaron ser los más activos contra M. domestica. Se seleccionaron los AEs de M. verticillata, C. sinensis y E. cinerea y sus respectivos Ts mayoritarios (4R)-(+)-pulegona, …
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A novel total synthesis of antillatoxin
In this thesis, the total synthesis of (4R,5R)-antillatoxin, one of the most ichthyotoxic metabolites isolated to date from cyanobacterium, Lyngbya majuscule, is presented. The synthesis proceeds from commercial available trimethylacetaldehyde and produce the molecule in an overall yield of 1.1% …
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Exoskeleton Robot for Upper Limb Rehabilitation: Design Analysis and Control
… shortcomings of past mechanism designs, a novel 4R mechanism is proposed. However, there are a range of kinematic designs of the 4R mechanism that can meet the performance requirements of a shoulder exoskeleton. To address this, a set of performance criteria are formulated and the NSGA II …
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Total synthesis of N-(benzyloxycarbonyl)didemnin A
… by coupling two key fragments, (Boc-(3S,4R,5S)-Ist(TBDMS)-(2R,S;4S)-Hip-Leu-Pro-OH (Fragment I)) and (Z- scD-MeLeu-Thr(H-Me$\sb2$Tyr)-OTMSe) (Fragment II). Fragment I was synthesized, in turn, from Boc-(3S,4R,5S)-Ist(TBDMS)-OH, Bn-(2R,S;4S)-Hip-OH, Boc- scL-Leu-OH and H- scL-Pro-OMe by …
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Best Practices in Leading Organizational Change in the Local Church: A Multi-Case Study
… and James Furr, and introduces Mark McCloskey’s 4R Model of Transformational Leadership as another model for consideration. Chapter 3 provides a detailed explanation of the research methodology of the research study while explaining the case studies in detail and the content analysis approach for …
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Tau Aggregation, Conformational Selection, and Inhibition
… giving rise to the naming convention of 3R and 4R Tau. In solution, full-length Tau exists as a disordered monomer in dynamic conformational equilibrium. This solution-phase heterogeneity could, in part, explain conformational diversity of Tau fibrils.</p> <p>A homogeneous set of Tau fibrils …
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Part I : Total synthesis and biological evaluation of antillatoxin and fragments Part II: Synthetic studies towards the total synthesis of cytochalasans and tuberostemonine
In part I, the total synthesis of natural (4R, 5R)-antillatoxin and its analogue (4S, 5S)-antillatoxin has been achieved in 9 steps in 23% overall yield. Our strategy provides practical and easy entry into key intermediates and analogues. Screening utilizing zebrafish embryos of this library of …
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Guanidino-aryl substituted enol lactones: Selective and potent mechanism-based inhibitors of trypsin-like serine proteases
… $\alpha$-benzamido substituted analogs (3R*,4R*) 3-benzamido-4-(guanidinophenyl)-6-methylidene tetrahydro-2-pyranone (7) and (3R*,4R*) 3-benzamido-4-(4-guanidinophenyl)-6(E)-iodomethylidene tetrahydro-2-pyranone (8).
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The Design and Synthesis of Novel Chiral Z-Nitrones with Applications Towards the Syntheses of Enantiomerically Pure 4-Hydroxy Amino Acids
… 4-hydroxy amino acids after several steps. (2R,4R) 4-hydroxyl-4-methylglutamic acid and (2R,4R) Monatin were both synthesized in high purity from corresponding olefins and the chiral carboisopropoxynitrone. Furthermore, the (2S,4S) enantiomers of both amino acids could be synthesized via …
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Optimization of Near Field Coupling for Efficient Power Transfer Utilizing Multiple Coupling Structures
… coupling. Previous research with mid-range (dâ 4r) wireless power transfer has resulted in coupling efficiencies of close to 40%. In order to increase efficiency in transfer a more directive transmission system was developed using a phased array. Coupling networks were used to shift the …
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Investigating the effects of tau mutations in induced pluripotent stem cell-derived neurons
… and three with 4 microtubule-binding repeats (4R, including exon 10). MAPT mutations cause the progressive, degenerative disorder fronto-temporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17T), in which tau becomes abnormally phosphorylated and aggregates. FTDP-17T related MAPT …
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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
… through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing these cytokines prevents or ameliorates disease significantly, while neutralizing IL-12 exacerbates disease symptoms. As many aspects of the mechanisms involving Th2 cytokines in colitis remain undefined, the aim of this study …
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Applications of EPR with an Emphasis on Tau Fibril Structure
… DEER was used to show that filaments of 3R and 4R tau are conformationally distinct and that 4R fibrils adopt a heterogeneous mixture of conformations. Populations of 4R fibril conformations, which were independently validated using a model system, can be modulated by introduction of mutations …
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Structures of the Didemnins (Antiviral, Antitumor, Compounds)
… (MeLeu), L-threonine (Thr), 3S,4R-statine (Sta), L-leucine (Leu), L-proline (Pro), and N,O-dimethyl-L-tyrosine (Me(,2)Tyr), and a 2R,4R-hydroxyisovalerylpropionyl (Hip) group. Didemnins B-E differ from didemnin A by acylation of the methylamino group of MeLeu with the …
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Desempenho operacional de um conjunto trator-semeadora-adubadora em plantio direto da soja
… 3 x 4, com três marchas reduzidas (2R, 3R e 4R) e quatro rotações no motor, (1600, 1800, 2000 e 2200 rpm) em delineamento em blocos casualizados, com quatro repetições, totalizando 48 unidades experimentais. O desempenho do conjunto foi avaliado por meio da demanda energética e qualidade da …
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