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Showing 1 to 6 of 6 for “"4-quinolones"”.
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The antioxidant properties of 4–quinolones compared to structurally related flavonoids
Oxidative stress is a common occurrence in neuro-degenerative disorders such as Alzheimer's and Parkinson's disease and is suggested to take place before the onset of neuro-degenerative disease, leading to, or exacerbating deterioration. The oxidative status of the cells is regulated by antioxidant …
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Development of a copper-catalyzed amidation-base-promoted cyclization sequence for the synthesis of 2-aryl- and 2-vinyl1-4 quinolones
… for the preparation of 2-aryl- and 2-vinyl-4-quinolones that utilizes a copper-catalyzed amidation of ortho-halophenones followed by a base-promoted Camps cyclization of the resulting N-(2-keto-aryl)amides is described. With Cul, a diamine ligand, and base as the catalyst system, the amidation …
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Specificity of aldehyde oxidase towards N-heterocyclic cations. Oxidation of quinolinium and related cations by aldehyde oxidase in vitro; the isolation of two products formed simultaneously from a single substrate.
… compounds. The N-heterocyclic cations and quinolones used required synthesis. Incubation of N-methylquinolinium, N-methyl-7,8-benzoquinolinium and N-phenylquinolinium yielded the corresponding 2- and 4-quinolones simultaneously. The ratio of 2- to 4-quinolone formation was found to be …
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Anticancer and antibiotic leads from marine organis
… including two phenazines, six 2-alkyl-4-quinolones, and seven rhamnolipids. 2-Nonyl-4(1H)-quinolone and 2-(1-nonenyl)-4(1H)-quinolone displayed potent antimalarial activity, which was first reported here. Based on the metabolic profile of antibiotics from P. aeruginosa, chemical …
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Homo- and heterodinuclear luminescent helicates
… and Gould-Jacobs methods yielding 4-quinolones in a two-step one-pot reaction.
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The Total Synthesis of Pseudonocardia sp. Quinolone Natural Products and Studies Towards the Total Synthesis of 1β-Hydroxyalantolactone
Natural products have long been known for their broad range of useful therapeutic properties, and have been widely utilised in the field of medicine. This dissertation describes work towards the total synthesis of natural products possessing biological activity in two important areas. The first …