Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"4-hydroxynonenal"”.
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The role of 4-hydroxynonenal in cellular signaling mechanisms
… that a physiological level of LPO product 4-hydroxynonenal (HNE) is necessary for maintaining key proliferation, adhesion, and survival signaling by regulating expression of genes involved in these pathways, and that alteration of that level either up or down will result in induction of genes …
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Ribonucleotide reductase in dividing cells: Purification and inhibition studies with 4-hydroxynonenal
… The effect of the lipid peroxidation product 4-hydroxynonenal (HNE) on CDP reductase from juvenile normal rat liver was investigated. HNE inhibited the CDP reductase activity. The inhibition was dependent on the concentration of HNE and the incubation time. The enzyme activity was reduced 500/0 …
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Effects of Acute Heat and Oxidative Stress on the Hepatic Expression of Orexin and Its Related Receptors
… stress using hydrogen peroxide (H2O2) and 4-hydroxynonenal (4-HNE) on the hepatic expression of ORX and ORXR1/2 in the avian species. Overall, heat stress significantly down regulated the expression of ORX, and ORXR1/2 mRNA and pro1tein in quail liver and LMH cells. LMH cells treated with …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
… in response to oxidative stress induced by 4-hydroxynonenal (HNE) in a ligand-independent mechanism. Furthermore, cleavage of the receptor was demonstrated to contribute to the death of sympathetic neurons following oxidative insult. This study investigates the effects of oxidative stress on …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… peroxidation (as measured by formation of 4-hydroxynonenal, 4-HNE), elevated cysteine levels, and death of photoreceptors resulting in outer nuclear layer thinning. NACA eye drops reversed these toxic effects. In conclusion, this potent antioxidant should continue to be investigated as a …
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Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
… of c-kit+Lin—Sca-1—Il7rα— cells and increases 4-hydroxynonenal (4-HNE). Levels of γH2AX, a marker of dsDNA breaks are also increased in fetal liver cell culture following 12.5 µM BQ exposure. Next, using an in vivo CD-1 mouse model of transplacental benzene carcinogenesis which previously showed …
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Activity-based sensors for reactive aldehydes and their corresponding enzymatic machinery
… We also aimed to develop a selective probe for 4-hydroxynonenal (4HNE). It is one of the most reactive and abundant aldehydes produced during oxidative stresses (i.e. lipid peroxidation) and has been connected to many age-associated conditions including cancer and neurodegeneration. We …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… of lipid peroxidation, an IHC staining for 4-hydroxynonenal (4-HNE) in addition to a malondialdehyde (MDA) colorimetric assay was performed. IHC staining for Caspase-3 was conducted to assess apoptosis. Finally, the effects of 20-HETE inhibition on the ferroptosis pathway were examined by …
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ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS
… hydroxyl radical (OH), peroxynitrite (ONOO−), 4-hydroxynonenal (4HNE), etc., have a tendency to react with nearby proteins/nucleic acids/lipids changing their functionality or inactivating them completely. The organism has many ways to protect itself from the harmful effects of oxidants. One …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… a marker of LDL), oxidized LDL (Ox-LDL) and 4-hydroxynonenal (4-HNE) was performed. In our in-vitro trophoblast cell model, modified lipoproteins decreased trophoblast cell viability in a concentration dependent manner and increased release of two anti-angiogenic factors, sFlt-1 and sEng into …
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Molecular analysis of the role of mitochondria in aging and lengevity
The Free Radical Theory of Aging states that there is an increase in reactive oxygen species (ROS) production with aging leading to increase in tissue dysfunction. Mitochondria are the major source of ROS, which damages essential macromolecules by oxidative modification and may lead to …
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Immunological and biosynthetic studies of the human pyruvate dehydrogenase complex
… to a major lipid peroxidation product, 4-hydroxynonenal. It was shown that E. coli lipoyl LplA ligase has a broad substrate specificity that was not exclusive to 8-carbon substrates; it can incorporate a range of saturated fatty acids of varying chain length (C6 to C12) and also branched …
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Kynurenines in neurological disorders
… peroxidation products, malondialdehyde and 4-hydroxynonenal. Patients with late stage HD showed abnormal tryptophan metabolism via the kynurenine pathway, together with increased inflammation and oxidative stress. Increased levels of kynurenine together with increased kynurenine: tryptophan …
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Feeding peroxidized soybean oil to finishing pigs: Effects on performance, nutrient digestibility, carcass characteristics, and the shelf-life of loin chops and commercially manufactured bacon
… were 2.07, 1.90, 912.15, and 915.49 mg/kg; and 4-hydroxynonenal concentrations were 0.66, 1.49, 170.48, and 82.80 mg/kg, for the 22.5, 45, 90 and 180°C processed SO, respectively. Pigs were individually housed and fed ad libitum for 81 d to measure growth performance, including a metabolism period …