Global ETD Search
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Showing 1 to 9 of 9 for “"4-HNE"”.
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Effects of Acute Heat and Oxidative Stress on the Hepatic Expression of Orexin and Its Related Receptors
… hydrogen peroxide (H2O2) and 4-hydroxynonenal (4-HNE) on the hepatic expression of ORX and ORXR1/2 in the avian species. Overall, heat stress significantly down regulated the expression of ORX, and ORXR1/2 mRNA and pro1tein in quail liver and LMH cells. LMH cells treated with H2O2 had decreased …
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SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES
… that can release a biocidic aldehyde, 4-HNE, upon photolysis, has been studied as a possible alternative to overcome this limitation of photodynamic therapy at present. The impact of variations in substitution, conditions and additives on the course of the mechanistic pathways involved in …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… an IHC staining for 4-hydroxynonenal (4-HNE) in addition to a malondialdehyde (MDA) colorimetric assay was performed. IHC staining for Caspase-3 was conducted to assess apoptosis. Finally, the effects of 20-HETE inhibition on the ferroptosis pathway were examined by measuring the mRNA and …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… Apocynin was found to reduce expression of 4-HNE, a lipid peroxidation product, in chronic SCI rats when administered intraperitoneally 30 minutes before perfusion and fixation. Evoked and non-evoked measures of neuropathic pain were reduced in chronic SCI rats when Apocynin was applied …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… (as measured by formation of 4-hydroxynonenal, 4-HNE), elevated cysteine levels, and death of photoreceptors resulting in outer nuclear layer thinning. NACA eye drops reversed these toxic effects. In conclusion, this potent antioxidant should continue to be investigated as a treatment for …
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Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
… cells and increases 4-hydroxynonenal (4-HNE). Levels of γH2AX, a marker of dsDNA breaks are also increased in fetal liver cell culture following 12.5 µM BQ exposure. Next, using an in vivo CD-1 mouse model of transplacental benzene carcinogenesis which previously showed that 200 mg/kg IP …
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Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… revealed extensive 4-hydroxy-2-trans-nonenal (4-HNE) modification of cathepsin B in UVA-exposed fibroblasts. Consistent with lysosomal impairment, accumulation of cellular autofluorescent material colocalizing with lysosomes was observed by confocal fluorescence microscopy, and extensive …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… by a reduction in GPX4 and an increase in 4-HNE. The use of antioxidants (TEMPOL, ferrostatin-1, and hydroxyurea) and iron chelators (deferiprone and, potentially, hydroxyurea) were able to ameliorate renal iron accumulation, oxidative stress, lipid peroxidation, and rhabdomyolysis-induced …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… oxidized LDL (Ox-LDL) and 4-hydroxynonenal (4-HNE) was performed. In our in-vitro trophoblast cell model, modified lipoproteins decreased trophoblast cell viability in a concentration dependent manner and increased release of two anti-angiogenic factors, sFlt-1 and sEng into cell supernatant. …