Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"4-AP"”.
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An investigation of the function of adaptor protein complex 4 (AP-4)
… bound transport intermediates by vesicle adaptors, which include those of the highly conserved adaptor protein (AP) complex family. Each AP complex has a distinct subcellular localisation and functions in the sorting of a specific subset of transmembrane cargo proteins. Adaptor protein …
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Mechanisms of thermal sensitivity in rodent primary afferent neurons innervating the skin
… rat was studied. Selective TRP channel agonists capsaicin, menthol, and mustard oil were then applied onto the receptive field of primary afferents to determine the expression pattern of thermosensitive TRP channels. The majority of cold sensitive A and C fibre nociceptors as well as …
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Functional and Categorical Analysis of Waveshapes Recorded on Microelectrode Arrays
… for up to several weeks. The signature wave shapes from extracellular recording of neuronal activity display a great variety of shapes with triphasic signals predominating. I characterized extracellular recordings from over 600 neuronal signals. I have preformed a categorical study by dividing …
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Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
… of the Kv channel blocker 4- aminopyridine (4-AP) in nonpregnant mouse myometrium, a response which is not mediated by nerves, the endometrium, or the large-conductance, voltage-activated potassium (BK) channel, and which disappears entirely in term pregnant myometrium. I have begun to explore …
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A neurophysiological and proteomic study of cognitive enhancing strategies
… using neurophysiological and proteomic approaches. The effects of two classes of putatively cognitive enhancing drugs on emergent network oscillatory activities in hippocampal slices are investigated. The effect of an enriched environment, which causes an improvement in cognitive …
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Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes
… cells, which share the common attributes of rapid cellular proliferation and invasion with tumor cells. The impact of VGLL1 in cancer has not been fully elucidated and no VGLL1-targeted therapy currently exists. The aim of this study was to evaluate the cellular function and downstream genomic …
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Papel de la corriente de freno Ixd en la hipersensibilidad dolorosa al frío inducida por lesión en neuronas sensoriales primarias
… neuralgia post-herpética, diabetes ó quimioterapia en cáncer y es en gran medida refractaria al tratamiento con analgésicos y antinflamatorios tradicionales. Algunos de los determinantes celulares y moleculares asociados al desarrollo de hipersensibilidad dolorosa al frío inocuo son hasta ahora …
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Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins.
… the hypoxic response in small porcine intrapulmonary veins in relation to the arterial response, and investigate the effects of hypoxia on ion conductances in single myocytes from intrapulmonary veins. In wire myography experiments, intrapulmonary veins contracted more than sizematched …
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Electrophysiological and morphological analyses in two species of insects, Protophormia terraenovae and Ceratitis capitata
… receptors and/or ion channels located in the apical membrane of taste receptor cells results in the generation of a receptor potential which, in turn, activates the ‘encoder’ region to produce action potentials which propagate to the CNS. This study investigates, in the labellar chemosensilla …
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Interactions of insecticidal spider peptide neurotoxins with insect voltage- and neurotransmitter-gated ion channels
… subtypes. The lethal insecticidal action of 4-AP in crickets further supports an action of ƙ-HXTX-Hv1c to block IK(A). The results of co-application experiments revealed that ƙ-HXTX-Hv1c blocks the same channel as the non-phylum selective vertebrate KV4 channel toxin, ƙ-sparatoxin-Hv1b. …