Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"4-1BBL"”.
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Studies of human T cell costimulation: potential for the immunotherapy of cancer
… encoding the costimulatory molecules CD80 and 4-1BBL (CD137L) and the cytokine IL-12 tumour cell lines were transduced to express these molecules individually or in combination in vitro. Using PBMC from healthy donors the effect of costimulation in response to pan-T cell stimulation with the …
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The State of T Cell Immunity against Influenza Virus in Humans and Exploration of Potential Strategies to Enhance Cell-Mediated Protection from Influenza Infection
… to induce persisting CD8 T cell responses. 4-1BBL signals during boost immunization resulted in superior numbers and function of persisting influenza-specific CD8 T cells. Since TRAF1, an adaptor molecule for 4-1BB signaling, is polymorphic in humans, a preliminary investigation was undertaken …
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Tolerizing Effects of Soluble CD137 on the CD137-CD137L Signaling Axis for Exploitation as a Therapeutic in Type 1 Diabetes
Las enfermedades autoinmunes (EAI) representan un desafío mayor y creciente para la salud global, siendo la diabetes tipo 1 (DT1) un ejemplo destacado. Estas enfermedades se caracterizan por una falla en la tolerancia inmunológica, lo que da lugar a la activación de células T patógenas que atacan a …