Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"3D scaffolds"”.
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3D scaffolds for tissue engineering produced by microfabrication technology
… 3-dimensional (3-D) regular and ordered scaffolds for tissue engineering applications. With these techniques, good architecture reproducibility as well as porosity control of the structure can be obtained. This work dealt with the fabrication of tissue engineering scaffolds with regular …
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Shape Memory Polymers as 2D Substrates and 3D Scaffolds for the Study of Cell Mechanobiology and Tissue Engineering
… field that combines cells, signals, and scaffolds to regenerate damaged tissues. To develop new, functional, engineered tissues, it is becoming increasingly important to understand how cell-material interactions affect the cell mechanobiological response. As a result, recent efforts have …
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Development and evaluation of the innovative 3D printed scaffolds for bone regeneration in vitro and in vivo /
… morphology, printing accuracy, and porosity of 3D scaffolds printed from industrial polylactic acid (PLA) filaments with different FDM 3D printers. Innovative topologically ordered 3D scaffolds were created using the combination of hot melt extrusion and FDM technologies from PLA micro granules, …
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Antibiotic-free PHA-based antibacterial materials for bone regeneration
… negative bacteria. The possibility of developing 3D scaffolds using melt 3D printing of mcl-PHAs was investigated in this study for the first time. The process parameters were successfully optimized to produce well-defined and reproducible 3D P(3HO-co-3HD-co-3HDD) scaffolds. 3D scaffolds with dual …
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3D printing of hyaluronic acid scaffolds for tissue engineering applications
Direct-write assembly is used to fabricate 3D microperiodic scaffolds composed of hyaluronic acid (HA), a natural, biocompatible, biodegradeable polymer, for cell culture and tissue engineering applications. HA is functionalized with UV-curable glycidyl methacrylate (GM) and printed to create 3D …
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Factors affecting bone cell growth and differentiation under differing culture conditions
… with bone grafts, implantation of biodegradable 3D scaffolds seeded with MSCs has been suggested. However, differences in osteoblast differentiation in 2D versus 3D cultures remain unclear. In this study, rat marrow stromal cells (MSCs) were grown both on plastic and in 3D polymer scaffolds and …
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Development of novel diagnostics and therapeutics for amyotrophic lateral sclerosis
… poly(glycerol-co-sebacate) acrylate (PGSA) and 3D scaffolds for human embryonic stem cell (hESC) and neuronal encapsulation.A Gd-TTC conjugate was developed and characterized that was shown to be highly visible under MRI and preserved the functionality of the native TTC protein in vitro. Live …
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Enzymatic crosslinking of dynamic hydrogels for in vitro cell culture
… In recent years, cell-laden three-dimensional (3D) scaffolds with controllable properties are also increasingly used. However, current 2D and 3D culture platforms do not permit spatiotemporal controls over material properties that could influence tissue processes. To address this issue, …
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The Influence of Structure and Surface Biochemistry on Cell Function and Angiogenesis in Collagen Scaffolds
… following implantation. Ice-templated collagen scaffolds have been used in tissue engineering due to their bioactivity, tunable biodegradability and the ability to produce architectures with tailored porosity, but until now very little work has focused on vascularisation of these structures. The …
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… the complexity of the native three-dimensional (3D) tumor microenvironment, resulting in a lack of correspondence between preclinical data and clinical trial outcomes. The establishment of high-throughput 3D models able to describe distinctive aspects of the tumor niche would advance our …
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Bioactive Cellulose Nanocrystal Reinforced 3D Printable Poly(epsilon-caprolactone) Nanocomposite for Bone Tissue Engineering
Polymeric bone scaffolds are a promising tissue engineering approach for the repair of critical-size bone defects. Porous three-dimensional (3D) scaffolds play an essential role as templates to guide new tissue formation. However, there are critical challenges arising from the poor mechanical …
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The influence of collagen-GAG scaffold architectural and biological cues on tenocyte and mesenchymal stem cell bioactivity for musculoskeletal tissue engineering
… studies here use collagen-glycosaminoglycan (CG) scaffolds, regulatory compliant analogs of the native ECM that have been applied to the regeneration of dermis, peripheral nerve, and osteochondral tissue. Chapter 2 quantifies the role CG scaffold relative density plays in directing tenocyte …
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Near-Field Electrospinning and Characterization of Biodegradable Small Diameter Vascular Grafts
… regeneration. Therefore, the ability to create scaffolds with program-specific architectures independent of fiber diameter via the relatively recent sub-technique of near-field electrospinning (NFES) represents a promising solution to create tissue engineering vascular grafts. These programmed …
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Self-assembling amphiphilic peptides: A novel approach to create new drug systems and three-dimensional scaffolds for tissue regeneration. A resourceful mine not yet fully explored
… as a drug and as a drug carrier, simultaneously. 3D-scaffolds for tissue engineering applications are another hot area in which self-assembling peptides are finding several applications. Driven by this motivation, chapter 3, 4 and 5 describe how I designed, synthesized and investigated the …
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STUDIES OF CELL MOTILITY AND DIFFERENTIATION IN COMPLEX 3D IN VITRO MICROENVIRONMENT
… which are highly regulated by the complex 3D in vivo microenvironment, have been extensively studied in the past decades to better understand the mechanisms of development, disease, and healing. Due to the highly complex nature of the in vivo environment and limited resources and access to …
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Architectural, mechanical and biochemical control of collagen films and scaffolds to guide neural- and fibroblast cell behaviour
Collagen-based scaffolds offer the potential to bridge gaps in damaged nerves via infiltration of cells along oriented pore structures which can guide sprouting axons and direct Schwann cell migration. Neural cells have been shown to be highly mechanosensitive and hence substrate stiffness is an …
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Application of Fluid Flow for Functional Tissue Engineering of Bone Marrow Stromal Cells
… culture of osteoprogenitor cells within 3D scaffolds stimulates phenotypic markers of osteoblastic differentiation, but those studies did not determine whether the effects were a consequence of shear stress or increased nutrient availability. Consequently, this work has involved studies …
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Direct-write assembly of 3D microperiodic scaffolds for tissue engineering applications
Three-dimensional (3D) microperiodic scaffolds have been fabricated by direct-write assembly for tissue engineering. Such scaffolds are necessary to accurately mimic the complex environment of real tissues. Three distinct inks have been developed: (1) a hydrogel ink that contains high molecular …
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Characterize the molecular dynamics of materials for 4D printing
… that is foundational for fabrication of complex 3D objects with programmable, temporal attributes that undergo exceptional configuration changes of the 3D structure. While gel-based composite inks are at the crux, the lack of a foundational, materials chemistry printing-centric approach results …
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Evaluation of cellular interactions with functionalized scaffolds for cardiovascular tissue engineering
… valve tissue replacement surgery. Synthetic scaffolds used in tissue engineering often do not have sufficient cell adhesion, thus the addition of biosignals is crucial. Surface modifications can be used to improve desired cell adhesion and proliferation. To covalently attach cell adhesion …
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