Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"3D scaffold"”.
-
FABRICATION AND CHARACTERIZATION OF CELL-LADEN 3D PRINTED HYBRID SCAFFOLDS FOR ESOPHAGEAL TISSUE REPAIR
… are hardly used to achieve a suitable scaffold for esophageal TE. In this study, a hybrid porous scaffold consisting a layer of electrohydrodynamic jet printed (E-jetted) polycaprolactone (PCL) / Pluronic F127 (F127) fiber mesh, and a layer of electrohydrodynamic sprayed (E-sparyed) …
-
A NOVEL MAGNETIC THREE-DIMENSIONAL LEVITATED PRIMARY CELL CULTURE SYSTEM FOR THE DEVELOPMENT OF IN VITRO SALIVARY GLAND-LIKE ORGANOIDS
… cell-based approaches in three-dimensional (3D) scaffold-based systems. The majority have nonhuman-based components. Therefore, this project aims to develop SG mini-glands/organoids using a novel 3D xeno-free system (M3DL) that assembles and levitates magnetized primary SG-derived cells …
-
Development of collagen-based scaffolds for differentiation of induced pluripotent stem cells
… been broadly studied and applied in engineering 3D scaffold materials in tissue engineering. A collagen hydrogel can provide cells with a porous and soft environment to proliferate and differentiate. However, lacking mechanical stiffness and shrinkage resistance made it a challenge to sustain …
-
Synthetic polypeptide-based hydrogel systems for biomaterials
… cells need physical support in the form of a 3D scaffold with both chemical and mechanical signals. The Hammond group previously reported the combination of synthetic polypeptides with modified side chains available for click chemistry at quantitative grafting efficiencies. Herein, new schemes …
-
Investigation of non-intercalation electrode materials for next-generation batteries
… of FeF2 conversion cathodes coated on a 3D Ni scaffold with a thin layer of Al2O3 are studied. The 3D scaffold improves the reaction kinetics and enables a high specific capacity by providing an efficient electron pathway to the insulating FeF2 and shortening Li diffusion length. Al2O3 …
-
Optimizing alginate-chitosan microcapsules using co-axial air flow method as 3d stem cell microenvironment
… engineering because it provides a more effective 3D scaffold that can mimic the cell microenvironment. The benefits of using microcapsules are biocompatibility, biodegradability, nontoxicity, and formation under mild gelation conditions. In this study, the ability of the alginate microcapsules to …
-
Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft
… cells activity. We also investigated various scaffold formulations and seeding techniques for enhanced cellular entrapment and high cell proliferation. In-vitro, 3D scaffold cultures under non-pulsatile and pulsatile flow conditions were explored to generate vascular grafts with appropriate …
-
A novel osteochondral composite consisting of a self-assembling peptide hydrogel and 3D printed polycaprolactone scaffold : potential for articular cartilage repair
… peptide hydrogel with an interconnected porous 3D printed polycaprolactone (PCL) scaffold to create a novel osteochondral construct. The self-assembling peptide hydrogel has been shown to provide an environment that maintains chondrocyte phenotype and viability. Furthermore, the 3D scaffold …
-
M13 virus-enabled assembly of 3D nanostructured composites : synthesis and applications in solar energy conversion and electrochemical energy storage devices
… virus hydrogel that served as a multifunctional 3D scaffold capable of binding gold nanoparticles (AuNPs) to the virus proteins. The AuNP-virus hydrogel was encapsulated in titanium dioxide (TiO₂) to produce a plasmon-enhanced nanowire (NW)-based DSC photoanode that enabled a power conversion …
-
Mesenchymal stem cells as trophic mediators of neural differentiation
… of MSCs cultured on AlvetexTM, a novel, 3D scaffold manufactured by ReInnervate, with particular emphasis on the ability of MSCs to undergo osteogenic and adipogenic differentiation. Results obtained suggest that AlvetexTM may provide a more realistic and physiologically-relevant system …
-
STUDIES OF CELL MOTILITY AND DIFFERENTIATION IN COMPLEX 3D IN VITRO MICROENVIRONMENT
… which are highly regulated by the complex 3D in vivo microenvironment, have been extensively studied in the past decades to better understand the mechanisms of development, disease, and healing. Due to the highly complex nature of the in vivo environment and limited resources and access to …
-
The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer
… of Cellular Environment and Response (TRACER), a 3D scaffold that develops oxygen and nutrient gradients similar to those observed in tumours. Using TRACER, I show that the main metabolic signature of FH loss, which is driven by the high levels of fumarate, is not influenced by the nutrient and …
-
Hierarchical Carbon Structures for Advanced High Areal Capacity Lithium-Ion Battery Electrodes
… direct-spun CNT mats are proposed as conductive scaffolds for lithium metal anodes (LMAs), which are desirable for next-generation batteries because of their ultra-high energy density. However, the practical applications of LMAs are hindered by the inhomogeneous Li dendrite formation during …
-
Design, Fabrication, and Characterization of Carbon Nanotube Field Emission Devices for Advanced Applications
… and a Low Temperature Cofired Ceramic (LTCC) 3D scaffold with integrated ion optics were developed and characterized. While previous research has shown other devices capable of collecting ion currents on chip, this LTCC packaged MEMS micro-ion source demonstrated improvements in energy and …
-
DEVELOPMENT OF A NEXT-GENERATION IN VITRO PLATFORM FOR IN-DEPTH EVALUATION OF ALTERNATIVE SUSTAINABLE FISH FEED FORMULATIONS
… enriched with fibroblasts, or alternatively, a 3D scaffold populated with fibroblasts that produced their own extracellular matrix was used. The latter, though more complex and time-consuming, proved to be the most effective in promoting epithelial cell differentiation and barrier formation. In …
-
Development of an artificial silk protein on the basis of a lacewing egg stalk protein
… are filled with a mesh of nano fibres building a 3D scaffold. Films are a morphology with potential for application in cell culture. Fibroblast attachment on N[AS]8C films is quite poor. Therefore, we tried to induce guided fibroblast growth on patterned protein films. A first layer of the films …
-
Development and characterisation of a human in vitro model of the Neurovascular Unit using a biomimetic tissue engineered system
… that they do not fully recapitulate the complex 3D microenvironment of the NVU, which can negatively impact cell behaviour and signalling pathways. Additionally, in 2D models, shear stress and other mechanical forces experienced by endothelial cells are not representative of physiological …
-
A Novel Technique for Fabricating Aligned Nanofibers by Using Solution Electrospinning
<p>In this Master of Science project, a novel technique of producing aligned nanofibers has been created by using new designed apparatus. Solution electrospinning has been used for nanofibers fabrication. During solution electrospinning, when two negative (-20kV) charged wheels and a positive …