Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"3D in vitro models"”.
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
… cells (MSCs) have great potential to improve clinical outcomes for many inflammatory and degenerative diseases through delivery of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined …
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Developing bioelectronic sensors for 3D in vitro models at the air liquid interface: Innovative technology for biomedical and respiratory research.
Respiratory diseases and airborne infections are significant global health issues and a major cause of morbidity and mortality worldwide. According to the World Health Organization (WHO), respiratory diseases rank as the third leading cause of death globally, with over 10 million deaths per year …
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The Convergence of Accelerated and Physiological Vascular Ageing: A Multi-Omic Analysis of 2D and 3D in vitro models of Progeria
Cellular and molecular hallmarks of ageing contribute heavily to onset of vascular disease with age. With the average age of global populations increasing, the associated rise in vascular diseases presents a huge challenge. A key obstacle in vascular gerontology research is a lack of suitable in …
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An In Vitro 3D Model to Evaluate Behaviour of Breast Cancer Cells and Response to Treatment
The field of 3D culture models of disease has started to move towards systems that aim to recapitulate the complexity of human tissues. However, despite recent improvements, current 3D systems remain overly simplistic, lacking the biophysical characteristics and diverse structures found in most …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
Keratins are fibrous structural proteins found in human hair that have been used to develop bioactive and biocompatible constructs for a wide variety of tissue engineering and healthcare applications. Their ubiquity, capacity for self-assembly, ease of use and versatility in blended materials, and …
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Development and Utilization of a Bioengineered 3D Human Lung Model to Study Pathogenesis of Lung Disease
There is a great need for research models that mimic human lung physiology and lung pathologies such as chronic lung diseases and respiratory infections. The morbidity and mortality associated with lung disease and respiratory infections represent a global burden. Pathogenesis of these diseases and …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… have a lifetime prevalence of nearly 30%, resulting in $13 billion in annual economic burden. The greatest refractory cause of dysphonia, defined as poor voice, after laryngeal injury is vocal fold (VF) scarring, which typically follows upper airway trauma or iatrogenic injury. After initial VF …
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3D KIDNEY ORGANOIDS AS A PLATFORM FOR INVESTIGATING MONOGENIC DISEASES AND GENE THERAPY APPROACHES
Abstract The use of 3D in vitro models is now widely adopted in biomedical research. These models enable the study of human cells under more physiologically relevant conditions and allow for early proof-of-concept testing of therapies prior to animal studies. While 3D models do not replace …
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AGGREGATION MECHANISMS OF TDP-43 PROTEIN IN RESPONSE TO STRESS IN AMYOTROPHIC LATERAL SCLEROSIS AND THERAPEUTIC APPROACHES
… (ALS) is a rare neurodegenerative disorder affecting upper and/or lower motor neurons for which no effective cure is available to date. The neuropathological hallmark of the disease, present in 97% of ALS cases, consists in TDP- 43 proteinopathy characterized by the accumulation of ubiquitinated …
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Strategies for Overcoming Shortcomings of Thermal Ablations: A Comprehensive Study of Nanoparticle Transport During Photothermal Chemotherapy Treatments, and High Frequency Irreversible Electroporation
Cancer continues to be a leading cause of death worldwide despite the increasing research advances into novel treatments. Thermal ablation of tumors is a relatively established method for the destruction of many tumor types, despite inherent shortcomings including incomplete tumor treatment and …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… neurological complications are reported in patients not only with severe disease, but also in otherwise minimally symptomatic or asymptomatic people [1–3]. Notably, up to 65% of COVID-19 affected patients reported a wide range of neurological conditions, such as decreased sense of smell …