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Showing 1 to 17 of 17 for “"3D in vitro model"”.
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Developing a 3D in vitro Model by Microfluidics
<p><em>In vitro</em> tissue models play an important role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D <em>in vitro</em> models allow the cells to grow and interact with their …
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A 3D in vitro model of the human gut-microbiome. A bioelectronics approach.
… human gut microbiota has emerged as a key player in the bidirectional communication of the gut-brain axis, affecting various aspects of health and disease. Although a vast array of studies have revealed the specific role of gut microbiota in various physiological and pathophysiological conditions, …
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A THREE DIMENSIONAL MODEL OF HUMAN HEPATO-BILIARY ORGANOGENESIS
In recent years, tissue engineering strategies have emerged aimed at generating functional liver tissue by using decellularized liver scaffolds repopulated with liver cells. The quest continues for identifying the best cell source for liver tissue engineering, but one cell source in particular, …
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IN VITRO MODEL OF GLIOBLASTOMA TO STUDY THE EFFECTS OF BRAIN MICROENVIRONMENT AND ITS MECHANICAL PROPERTIES ON TUMOR CELLS
… (GBM) is one of most aggressive forms of brain cancer with a median survival rate of 14.6 months, and the two-year survival rate is 30%, which has not seen significant improvement in the last 100 years. This low survival rate could be in part attributed to the fact that there is a lack of …
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Biomimetic platforms for modeling in vitro the functional unit of the exocrine pancreas
Pancreatic ductal adenocarcinoma (PDAC), commonly known as pancreatic cancer, is the most frequent type of exocrine pancreas tumors and one of the leading causes of cancer-related death worldwide with a five-year survival rate around 10%. The main reason that leads to consider PDAC a notably …
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Use of a 3D liver microreactor as an in vitro model for the study of bile acid synthesis and hepatobiliary circulation
The liver regulates a myriad of vital functions including bile acid synthesis, hepatobiliary circulation, cholesterol homeostasis, drug metabolism, etc. This thesis focuses on the use of a 3D in vitro model of liver to study the effects of compounds and culture conditions on hepatobiliary transport …
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Bioastronautics: Biological Modeling of the Neural Response to Space Radiation and its interaction with Alzheimer's Disease Risk Genes
The exotic radiation permeating interplanetary space remains the least understood and perhaps most challenging intrinsic barrier to a sustained human presence beyond Earth. As the coming decade brings the promise of continuous lunar habitation and even the first voyage to another planet, …
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Human Brain Organoids for Studying Malignant Cell States and Intercellular Communication in Human Glioma
Human glioma is an incurable cancer of the central nervous system. Recent advances in glioma biology have highlighted the heterogeneity and inter-cellular communication within these tumors; it follows that appropriate models for studying glioma behavior and progression – and, in turn, therapeutic …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… (GBM) is the most deadly and common form of brain cancer and is responsible for over 50% of adult brain tumors. A specific region within the GBM environment is known as the perivascular niche (PVN). We have designed a 3D in vitro model of the PVN comprised of either collagen Type 1 or HyStem-C®, …
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Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair
… worldwide, preceded only by lung cancer. Current models for PLC either fail to fully recapitulate tumour histology and architecture or are expensive, time consuming and do not allow for personalised drug testing. During the first part of my PhD, I have collaborated with Dr. Laura Broutier in order …
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Hydrogel platform to investigate progression of drug-resistant glioblastoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… has previously identified a novel small molecule inhibitor, CHL-4, whose anti-tumour effects function through Lyn kinase, a member of the Src family kinases. This current study characterised a novel immunomodulatory role for CHL-4, which is able to increase gene and protein expression of Type …
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Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
… steatotic liver disease (MASLD), is the leading cause of chronic liver disease (CLD) and liver-related morbidity and mortality worldwide. NAFLD, characterized by hepatic fat accumulation and coexisting cardiometabolic risk factors, is often clinically associated with liver fibrosis, with a …
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Strategies for Overcoming Shortcomings of Thermal Ablations: A Comprehensive Study of Nanoparticle Transport During Photothermal Chemotherapy Treatments, and High Frequency Irreversible Electroporation
Cancer continues to be a leading cause of death worldwide despite the increasing research advances into novel treatments. Thermal ablation of tumors is a relatively established method for the destruction of many tumor types, despite inherent shortcomings including incomplete tumor treatment and …
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DEVELOPMENT OF NOVEL BIOTECHNOLOGICAL APPROACHES FOR ACCELERATING GENETIC GAIN IN THE BOVINE
Modern livestock production is increasingly challenged to improve reproductive efficiency while maintaining sustainability and animal welfare standards. Accelerating genetic gain in cattle (Bos taurus) is essential for breeding animals that are more resilient to climate change, more resistant to …
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Using electrical stimulation responses to understand cochlear implant status
… for patients with severe to profound sensorineural hearing loss. CIs stimulate the auditory nerve with current pulses on a multi-electrode array that is placed inside the cochlea. Success of CIs varies based on a wide range of patient-related and implant-related factors. In this thesis, I …
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3D in vitro skin model as broadly available multipurpose platform
… è presente nell'allegato / the abstract is in the attachment