Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"3D genomics"”.
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Uncovering Functional Alzheimer’s Disease Variants and Their Effector Genes through Single-Cell CRISPRi Screening and 3D Genomics
… fine-mapping of GWAS variants by leveraging our genomics datasets comprising ATAC-seq, RNA-seq, and high-resolution promoter-focused Capture C from brain-relevant cell models. We identified 89 candidate causal SNPs and 69 effector genes. Second, we designed a single-cell CRISPRi screen to perturb …
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The evolution of gene regulatory landscapes in mammalian tissues
… Technological advancements in the field of 3D genomics now enable the investigation of spatial chromatin interactions underlying gene regulation and genome organization. Thus, in the third chapter of the thesis, I described several strategies for creating custom capture-HiC probe sets to …
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Investigating the function of DNA G-quadruplex structures in human enhancers
… (G4s) are four-stranded DNA three-dimensional (3D) structures, that form in guanine-rich regions of the genome. G4s are enriched at sites of important regulatory potential in diverse genomes, including promoters and enhancers. Enhancers interact with target promoters through 3D folding of …