Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"3D genome organization"”.
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How Chromosome-Nuclear Envelope Attachments Affect 3D Genome Organization
… for gene expression and regulation. Thus, genome sequences must be understood in the context of their 3D organization which critically influences the flow of information. The effort to understand this added complexity now encompasses an entire field of chromosome biology and is reshaping …
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Analysis of 3D Genome Organization in 4-Cell Mouse Embryos
… has shown a tight coupling between the spatial organization of the genome inside the cell nucleus and a cell’s gene expression profile, in order to gain insights into cell fate determination, we studied the 3D genome organization; in particular how chromosomes are arranged in the 3D space of the …
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Computational methods for analyzing and modeling gene regulation and 3D genome organization
… analyzing and linking gene expression with the 3D organization of the genome. First, I describe methodologies for elucidating gene regulatory mechanisms by considering multiple data modalities. I design a computational framework for identifying colocalized and coregulated chromosome regions by …
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The role of MLL4 in the chromatin framework: from the epigenome to 3D genome organization
… haploinsufficiency, TrxG members show reduced genome binding, while PcG strengthens its enrichment and genome occupancy. This chromatin state rearrangement is also reflected on a three-dimensional scale. Genome Architecture Mapping (GAM) experiments reveal distinct changes in 3D chromatin …
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Dissecting The Roles of Human Smc Complexes In Transcription Regulation and Chromatin Organization
… elements and genes in the three-dimensional (3D) genome. However, the hierarchy of chromatin contacts and their underlying mechanisms are not well-understood. SMC complexes including Cohesin complex and Condensin complex has been widely proposed to organize 3D genome structure, and further …
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"""TSA-Seq"": a novel proximity mapping approach for studying three dimensional genome organization and function"
"The organization of chromatin and its localization in the eukaryotic cell nucleus plays a critical role in gene regulation (Agarwal and Rao, 1998; Brown, 2003; Ferrai et al., 2010) and is important for maintaining normal genome function. However, although it is known that the distribution of …
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Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
… at least in part, to significant alterations in 3D genome organization and epigenetic landscape following SARS-CoV-2 infection that are distinct from and more severe than changes caused by other viral infections or immune stimulants. While these changes at the chromatin level are important for …
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New insights into 3D genome architecture through improved genomic methods
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01