Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"3D bioprinting"”.
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3D Bioprinting Pediatric Trachea
… extracellular matrix (ECM) into bioinks for 3D bioprinting patient specific, tissue engineered constructs. The results discussed in this dissertation show while ECM is a powerful mediator of cell behavior, its efficacy can be inhibited by chemical modification. Lastly, this work investigates …
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3D bioprinting of pancreatic islets
Hintergrund/Ziel: Um Langzeitkomplikationen bei Diabetes mellitus Typ 1 (T1D) zu verhindern, können Spenderinseln transplantiert werden, was allerdings lebenslange rigorose Immunsuppression erfordert. Durch Verkapselung der Inselzellen kann die Immunsuppression umgangen werden, aber Upscaling ist …
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3D Bioprinting of Advanced Bioinks for Tissue Engineering Applications
… to the recently emerged three-dimensional (3D) bioprinting technology for the fabrication of functional tissue-engineered scaffold loaded with cells due to its ability to assemble complex structures with meticulous control over the entire fabrication process. It is a computer-assisted …
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TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING
… a new platform for engineering bone tissue using 3D bioprinting strategy has the capability of combining multiple clinically relevant biomaterials in biomimetic designs to improve outcomes for engineered bone graft substitutes. The aim of these explorations is to move outcomes toward clinical use …
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3D Bioprinting of High Cell Density Bioink for Chondrogenic Differentiation in Replacement Tracheal Rings
… were fabricated using a high cell density 3D bioprinting system into a support bath of oxidised, methacrylated alginate (OMA) hydrogel. A comprehensive characterisation of various formulations of the hydrogel was conducted to tabulate rheological and mechanical properties, and identify …
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Phase behaviour and structure formation of alginate-protein composite gels used in 3D bioprinting
… with a key application in extrusion-based 3D bioprinting. Alginate offers favourable printability and rapid ionic gelation but lacks cell-adhesive properties. Gelatin addresses these limitations by providing RGD motifs essential for cell attachment and enhancing scaffold porosity through …
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Development of a 3d bioprinting system, characterisation of bioink and printing microspheroids of hela cells
In Malaysia, Industrialised Building System (IBS) has been recognised as a potential solution in improving the deliverables of construction projects. However, the acceptance of this modern technology is still low. Most of the construction players prefer the conventional construction method which …
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The development of novel hybrid poly (2-oxazoline)-based bioinks for 3D bioprinting: a comparative study with Pluronic F127
Bioprinting has emerged as a cutting-edge technology to overcome the shortage of tissues and organs by the precise deposition of living cells and biomaterials into three-dimensional (3D) biomimetic constructs. However, the inadequate choice of bioinks has limited its widespread implementation and …
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Engineering of tools for De Novo Assembly of Human Cells
… Top-down approaches, such as microfluidics and 3D bioprinting, provide spatial control by patterning cell types with high resolution, but face challenges in reproducing physiologically accurate cell types and interactions. Bottom-up methods, such as organoids, induce pluripotent cells to …
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Development of Chemically-Defined Platform Materials for Localized Delivery of RNA Therapeutics
… can be used as a cell culture scaffold through 3D bioprinting. This hydrogel can be used to encapsulate cells of interest for future efforts in high throughput screening to allow for improved selection of RNA therapeutics and LNP design for local delivery.
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Novel Advances in Bioprinting Based on the Mechanical Design and Optimization of Open-source Systems
Three-dimensional (3D) bioprinting promises to be a practical solution for solving the increasing demand for organs and tissues. Several 3D bioprinters with different specifications are commercially available, but the impact on the field of tissue engineering (TE) is still limited, mainly due to …
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Development of a hydrogel-based microfluidic model of the lymph node
… physiological cell morphology in the new 3D environment. In addition, a LN-like architecture was achieved where B cells are segregated from T cells, into B cell follicles. After optimization of the 3D cellular system with built-in fluidics, I applied the model to different context. …
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Tissue-engineered in vitro models for studying lymphatic morphogenesis, pathogenesis, and drug delivery
… Then, I discuss the double-casting sacrificial 3D printing method to study lymphatic valve morphogenesis and inflammation-induced lymphatic valve dysfunction. Finally, I discuss the use of initial lymphatic vessel-on-chip devices to study nanoparticle delivery to lymphatic systems, revealing …
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Hyaline Cartilage versus Fibrocartilage Formation within Mechanically Loaded Cartilage Constructs: In Vitro and In Vivo Studies
… to their ability to provide a three-dimensioanl (3D) environment for maintaining chondrogenic phenotype in chondrocytes. It has been reported that in static cultures, hydrogel constructs have shown promise in producing key markers of hyaline cartilage, including GAGs and Col2, while producing low …
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Sensing in 3D Printed Neural Microphysiological Systems
… and tissues through augmentation of the 3D printing systems and developing novel modeling capabilities. The second objective was to expand the palette of available materials which exhibit the rheological properties required for 3D printing and the mechanical and biological properties …
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
… we use biomaterial and three-dimensional (3D) printing strategies to begin dismantling these tradeoffs, advancing sacrificial templating towards organ-scale engineered tissue vascularization. First, we address biocompatibility and scalability challenges by embedding microparticles within …
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Development of a methodology for applying shear stress to suspended mammalian cells
… stress in situations such as microfluidics, bioprinting and bioreactors. Being exposed to such stresses alters cell integrity, which affects their downstream applications, including drug screening and tissue regeneration. Current methods of loading shear stress onto suspended cells can be …
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Bioartificial scaffolds with biomimetic fibrous structure in the design of in vitro models of cardiac fibrotic and skeletal muscle tissue
L'abstract è presente nell'allegato / the abstract is in the attachment
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3D in vitro skin model as broadly available multipurpose platform
L'abstract è presente nell'allegato / the abstract is in the attachment