Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"3D aggregates"”.
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Novel Micropatterned Substrate for Investigation of Ovarian Cancer Aggregate Formation and Response to Epigenetic Drug Therapy
… The current consensus in cancer research is that 3D microenvironments are needed to better mimic in vivo response of tumors to drugs. This study will evaluate the feasibility of using a novel micropatterned substrate that enables 3D microenvironments for in vitro investigations of OvCa. The …
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Interfacial Characterization of Polyhedral Oligomeric Silsesquioxane (POSS) Amphiphiles and Polymer Blends: Thermodynamics, Morphology, and Rheology
… monolayers (1 POSS molecule thick) to various 3D multilayer films upon compression. With small length/diameter ratios and bulky shapes, the monolayer phase behavior and packing states of different POSS are simpler than the traditional rod-like lipids. Meanwhile trisilanol-POSS derivatives have …
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Bridging the Scale Gap: linking 2D proteomic and 3D tumour spheroid morphometric data using partial least squares structural equation modelling
… Immortalised cell lines can be cultured as 3D aggregates of cells referred to as ‘spheroids’. These spheroid cultures often exhibit responses to therapeutic agents more similar to that of tumours and can serve to bridge the efficacy gap between 2D and tumours in situ. <br/><br/>This research …
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Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro
… shown that ESCs formed into three-dimensional (3D) aggregates, called embryoid bodies, can become patterned and express genes associated with early tissue differentiation. However, embryoid bodies cannot recapitulate embryonic architecture and therefore may not accurately reflect what happens in …
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Engineered 3D microenvironments to understand and direct liver progenitor and cancer cell fate
… but there is a concerted effort to integrate 3D engineered systems in cell fate determination studies due to their more in vivo-like structure and the significant changes in microenvironmental cues they provide. In this dissertation, I describe two different 3D engineered systems to examine …