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Showing 1 to 8 of 8 for “"3CLpro"”.
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Untersuchungen zur Replikationsstrategie des humanpathogenen Norovirus
… Vorläuferproteins, das die komplette Sequenz der 3CLpro enthält, die 5`-seitig von der Spaltstelle zum VPg Protein und 3`-seitig vom N-Termins der 3DLpol flankiert ist, verifiziert werden. Infolge der kotranslationalen cis-Spaltung dieses Vorläuferproteins kam es zur Freisetzung der 3CLpro, die …
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Understanding the determinants for substrate recognition, regulation of enzymatic activity and the development of broad-spectrum inhibitors of coronavirus 3-chymotrypsin-like proteases
… Viral encoded 3-Chymotrypsin-like protease (3CLpro) is essential for viral polyprotein processing to release non-structural proteins that form the replicase complex machinery for viral genome replication. Due to its indispensable role in coronaviral replication, 3CLpro is an attractive drug …
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Charakterisierung der Substratspezifität coronaviraler 3C-like-Proteasen
… der Coronavirus-3C-like-Protease (3CLpro) dar. In der vorliegenden Arbeit wurde die Substratspezifität der coronaviralen 3C-like-Proteasen in vitro untersucht. Dazu wurden zunächst fünf verschiedene coronavirale 3C-like-Proteinasen (FIPV-, TGEV-, HCoV-, MHV- und IBV-3CLpro) …
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Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering
… of this thesis. In Chapter 3, the main protease 3CLpro of SARS-CoV-2 is enzymologically characterized. This work clarifies reported inconsistencies in enzymological features of this key viral protease and relies on a non-Michaelis–Menten, Bayesian inference-based analytical technique to …
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Use of Structure-And Ligand-Based Drug Design Tools for the Discovery of Small Molecule Inhibitors of Cysteine Proteases for the Treatment of Malaria and Sars Infection
… the known inhibitors in the binding site of SARS-3CLpro, a cysteine protease important for replication of SARS virus, to study the overall stability of the binding site interactions as well as identify important changes in the interaction profile that were not apparent from the docking study. …
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ENDOGENOUS ANTIVIRAL PROPERTIES OF RED BLOOD CELL-DERIVED EXTRACELLULAR VESICLES AND THEIR AUGMENTATION OF ANTIVIRAL OLIGONUCLEOTIDE THERAPY
… ASOs targeting conserved viral genes (helicase, 3CLPro, PLpro, RdRp, and TRS), delivered via RBCEVs, significantly suppressed viral replication in vitro and in vivo, improving survival in infected K18-ACE2 mice. Using the IDentif.AI platform, we identified synergistic ASO-loaded RBCEV …
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Coronavirus Replicase Proteins: Multifunctional Mediators of Replication and Innate Immunity Evasion
… the papain-like (PLP) and picornavirus 3C-like (3CLpro) proteases. The nsps modify host membranes to produce double membrane vesicles (DMVs) upon which the replicase-transcriptase assembles and synthesizes viral RNA. nsp3, nsp4, and nsp6 are integral membrane proteins believed to be involved in …